Prevalence of thyroid hormone autoantibodies in healthy subjects

Sakata, Shigeki; Matsuda, Masafumi; Ogawa, Teiichiro; Takuno, Hiroshi; Matsui, Ikuo; Sarui, Hiroshi; Yasuda, Keigo

doi:10.1111/j.1365-2265.1994.tb02558.x

Cited by 63 publications

(36 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[4][5][6][7][8]15,19 This study suggests that the diagnosis of an autoimmune disorder has to be made cautiously taking into consideration that autoantibodies are present in low titres in the healthy population. The normal ranges for common autoantibodies that we have established for the Omani population may be a useful guide for diagnostic purposes.…”

Section: Discussionmentioning

confidence: 99%

Frequency and Levels of Autoantibodies in Healthy Adult Omanis

2003

View full text Add to dashboard Cite

Background: A previous pilot study showed a high frequency of anti-smooth muscle autoantibody in Omani blood donors and pregnant women. We conducted this larger-scale study to investigate the frequency and significance of several autoantibodies in healthy individuals from different regions of Oman. Methods: Sera obtained from 1537 healthy Omanis (1153 males and 384 females), ranging in age from 18 to 57 years, were tested for the presence of ten different autoantibodies using indirect immunofluorescence, haemagglutination and latex agglutination techniques. Results: Low levels of autoantibodies were detected in 33.5%, whereas a few individuals (1.8%) showed high autoantibody titres. Anti-smooth muscle autoantibodies (ASMA) were the most prevalent (11%). Anti-nuclear autoantibodies (ANA) were the second most prevalent (7.6%). Anti-thyroid microsomal autoantibodies (ATMA) and anti-thyroglobulin autoantibodies (ATA) were present in 6.5% and 4.4% of individuals, respectively. The other autoantibodies were detected much less frequently: anti-parietal cells autoantibodies (APCA) were found in 1.6%, anti-brush border antibodies (ABBA) in 1.3%, anti-reticulin autoantibodies (ARA) in 1%, antimitochondrial antibodies (AMA) in 0.8%, antiglomerular basement membrane antibodies (AGBMA) in 0.7% and rheumatoid factor (RF) in 0.4%. Conclusion:The data indicate that autoantibodies are present in healthy Omani individuals, and therefore caution should be taken when interpreting laboratory results of patients suspected of having autoimmune disease. Ann Saudi Med 23 (6):372-375

show abstract

Section: Discussionmentioning

confidence: 99%

Frequency and Levels of Autoantibodies in Healthy Adult Omanis

2003

View full text Add to dashboard Cite

show abstract

“…As três principais classes de anticorpos que causam interferência nos imunoensaios dos HTs são os auto-anticorpos, os anticorpos heterófilos e o fator reumatóide. Os auto-anticorpos incluem os anticorpos anti-tireoglobulina, antitireoperoxidase, anti-receptor de TSH e os anticorpos anti-T 4 e T 3 (THAAb) (116,117). Os últimos (THAAb) são os mais raros, porém os únicos que interferem nos testes de função tireoidiana (118).…”

Section: Fatores Interferentes Nos Ensaios De T 4 E T 3 Total E Livreunclassified

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Graf

Carvalho

2002

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

Laboratory Interfering Factors in the Diagnosis of Hyper and Hypothyroidism.Since the first reports in the medical literature describing the clinical presentation of hypo and hyperthyroidism, very little has changed on the semiologic scenario of these entities and even in their therapeutic approach. The changing trends refer much more to the tools used to diagnose thyroid disease. In parallel with these developments, we understand much better about the factors that interfere in the interpretation of thyroid function tests in the diagnosis of hyper and hypothyroidism. In this article, we analyzed the utility of serum TSH and thyroid hormone measurements, as well the pitfalls and interferences in its common daily use. (Arq Bras Endocrinol Metab 2002;46/1:51-64)

show abstract

“…observed (7). Sakata et al (1994) screened 880 apparently healthy adults and reported that the incidence of anti-T3 or anti-T4 antibodies was 1.8% (4). The minimal effect of the antibodies on assays in these individuals could apparently be due to the lower association constants of these antibedles as compared to those used in the immunoassays.…”

Section: Adddress Forcorrespondencementioning

confidence: 99%

“…It is very rare that such autoantibodies are generated against the thyroid hormones themselves (2,3). The presence of these antibodies in serum does not onty complicate the clinical manifestations of the disease but also interferes with the estimation of total and free hormones by immuno assay (3,4,5). Their presence may be indicated when very low (undetectable) values of either or both T3 and T4 are observed in a competitive RINEIA that uses precipitation for the separation of" bound and free ligand (6).…”

mentioning

confidence: 99%

Interference of anti-T3 autoantibodies in the measurement of total and free T3 in serum

Rothman

Chawla

1997

Indian J Clin Biochem

View full text Add to dashboard Cite

A case of anti-tdlodothyronine sutoantibodies is presented in this report. The thyroid hormone profile of a hypertensive patient, with multinodular goiter and history of exogenous thyroid hormone therapy, was found to be highly ambiguous. The total as well as free T3 levels were consistently high (out of range) whereas the T4 (total and flee) values were always within normal limits. The thyrotropin was found to be partially suppressed. Very low T3-Uptake indicated some kind of interference in the immunoassays. We incubated the sera with the radio-iodine labelled T3 and observed that the patient's serum bound about ten times more radioactivity than a control run in parallel. On further resolving the serum proteins on cellulose acetate electrophoresis, the radioactivity was detected in the y-globulin band. Therefore it was established that the patient's serum carried the antibodies reactive with T3 which were interfering in the immunoassays. Elevated anti-thyroid microsomal antibodies were also present in the patient's serum. The anti-T3 antibodies were highly specific for T3 and did not show any cross reactivity with the T4 or its analogues used in the estimation of free T4.

show abstract

Prevalence of thyroid hormone autoantibodies in healthy subjects

Abstract: These results indicate that the occurrence of thyroid hormone autoantibodies among the healthy Japanese population is fairly common. However, interference of thyroid hormone autoantibodies in the radioimmunoassay of free thyroid hormones is exceptional.

Cited by 63 publications

References 27 publications

Frequency and Levels of Autoantibodies in Healthy Adult Omanis

Frequency and Levels of Autoantibodies in Healthy Adult Omanis

Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Interference of anti-T3 autoantibodies in the measurement of total and free T3 in serum

Contact Info

Product

Resources

About