Prevalence of Type 2 Diabetes, Impaired Fasting Glucose, and Diabetes Risk in an Adult and Older North-Eastern Portuguese Population

Magalhães, Paula; Teixeira, José E.; Bragada, João P; Duarte, Carlos M.; Bragada, José A.

doi:10.3390/healthcare11121712

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a crosssectional study evaluating the prevalence of T2DM in the adult northeastern Portuguese population, the percentage was higher than in the previously mentioned study with 17.4% and a direct association with the increase in age. Tis was attributed likely due to the declining per capita income compared to the European average, with the northeastern Portuguese region having a total lower per capita purchasing power than the national average [45]. When it comes to the prevalence of T2DM in Egypt, the country ranked ninth worldwide with 15.2%, with the number of adult T2DM patients being 8,850,400 in early 2020 [46].…”

Section: Diabetes Of the Ancient Arabo-islamic Worldmentioning

confidence: 99%

Diabetes Mellitus across the Arabo-Islamic World: A Revolution

Fleifel,

El Alam

2023

International Journal of Endocrinology

View full text Add to dashboard Cite

Background. Mankind continues to suffer from the ever-growing diabetes epidemic and the rapid rise of type 2 diabetes mellitus (T2DM). This metabolic disease has been studied since ancient civilizations. The Arabo-Islamic civilization excelled in establishing some of the most notable discoveries and teachings that remained the blueprint for years to come in the field of diabetology. Aim. This article aimed to review the ancient history of diabetes mellitus, with its main focus on the Arabo-Islamic civilization, and to report our subjective views and analysis of some of the past recommendations based on modern-day findings. Discussion. It is natural to have the teachings of medicine dynamically inspired by one civilization to another, as various fields continue to expand and evolve. This also applies to diabetology as the Arabo-Islamic world used the outlines of prior civilizations to revolutionize the understanding of the disease. Al-Razi and Ibn Sina are probably two of the most renowned polymaths in history, and their contributions to diabetology are well documented. Ibn Maymun’s postulation about the higher prevalence of diabetes in Egypt as compared to Andalusia is something to be carefully studied. It could be that diabetes mellitus’ underdiagnosis and late-stage detection are some of the major reasons for the disparity between the two mentioned regions. Modern-day Arabo-Islamic scholars continue to excel in revolutionizing diabetology. Conclusion. The Arabo-Islamic world houses an impressive bout of scholars who have contributed since the ancient times to diabetology. This scientific locomotion shows no signs of stopping, as it continues to shine during the present day, and likely in the future.

show abstract

Section: Diabetes Of the Ancient Arabo-islamic Worldmentioning

confidence: 99%

Diabetes Mellitus across the Arabo-Islamic World: A Revolution

Fleifel,

El Alam

2023

International Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

Risk stratification of type 2 diabetes in the Russian population depending on FINDRISC category: results of prospective follow-up

Balanova,

Shalnova,

Imaeva

et al. 2024

Cardiovasc Ther Prev

View full text Add to dashboard Cite

Aim. To study the risk of type 2 diabetes (T2D) using the Finnish Diabetes Risk Score (FINDRISC) and its contribution to all-cause mortality and cardiovascular events in the Russian population aged 25-64 years.Material and methods. Data from cross-sectional studies ESSE-RF and ESSE-RF2 are included. The random sample was formed using the Kish method. Response was ~80%. The modular questionnaire included socio-demographic variables, medical history, and main risk factors for noncommunicable diseases. Blood was collected from the antecubital vein on an empty stomach. Biochemical parameters were determined in the clinical diagnostic laboratory of the National Medical Research Center for Therapy and Preventive Medicine. The presence of T2D was determined by questionnaire and/or fasting plasma glucose level ≥7,0 mmol/L. Obesity was defined as a body mass index of ≥30,0 kg/m2; abdominal obesity was defined as a waist circumference of ≥102 cm in men and ≥88 cm in women. FINDRISC risk was graduated as follow: low (<7), slight (7-11), moderate (12-14), high (15-20), very high (>20). Persons with diabetes and pregnant women were excluded. The final sample included 26418 people (10268 men and 16150 women). From 14 regions, ESSE-RF and ESSE-RF2 formed a prospective follow-up cohort (n=22812), median follow-up — 7,5 years). Statistical processing was performed using the open-source statistical programming language and environment R (version 4.1).Results. A fifth of people aged 25-64 years are at ≥ moderate risk of T2D. The rate of FINDRISC ≥15 was 10,1% (women 12,4% vs men 6,4%, p<0,001); ≥12 points — 23,7%. A close relationship was found between impaired fasting glucose and the risk of T2D with FINDRISC ≥15 and ≥12 (p<0,001). Survival worsens for FINDRISC ≥12 and ≥15, with the worst survival rates in individuals with T2D (p<0,001). The likelihood of cardiovascular events consistently increases with FINDRISC ≥12, ≥15, and T2D. In the Cox model, only T2D is significant for all-cause mortality; FINDRISC ≥15 and T2D are significant for the cardiovascular and combined endpoints.Conclusion. An important task of the medical community is to identify individuals at risk of T2D at the population level. Early prevention of T2D risk factors can delay or prevent both T2D and cardiovascular events.

show abstract

Genetic Predisposition to Prediabetes in the Kazakh Population

Svyatova,

Berezina,

Murtazaliyeva

et al. 2024

CIMB

View full text Add to dashboard Cite

The aim of this study was to conduct a comparative analysis of the population frequencies of the minor allele of polymorphic variants in the genes TCF7L2 (rs7903146) and PPARG (rs1801282), based on the genome-wide association studies analysis data associated with the risk of developing prediabetes, in an ethnically homogeneous Kazakh population compared to previously studied populations worldwide. This study utilized a genomic database consisting of 1800 ethnically Kazakh individuals who were considered in healthy condition. Whole-genome genotyping was performed using Illumina OmniChip 2.5–8 arrays, which interrogated approximately 2.5 million single nucleotide polymorphisms. The distribution of genotypes for the TCF7L2 (rs7903146) and PPARG (rs1801282) polymorphisms in the Kazakh sample was found to be in Hardy–Weinberg equilibrium (p > 0.05). The minor G allele of the “Asian” protective polymorphism rs1801282 in the PPARG gene was observed at a frequency of 13.8% in the Kazakh population. This suggests a potentially more significant protective effect of this polymorphism in reducing the risk of prediabetes among Kazakhs. The frequency of the unfavorable T allele of the insulin secretion-disrupting gene TCF7L2 (rs7903146) in Kazakhs was 15.2%. Studying the associations of genetic markers for prediabetes enables the timely identification of “high-risk groups” and facilitates the implementation of effective preventive measures. Further results from replicative genomic research will help identify significant polymorphic variants of genes underlying the alteration of prediabetes status.

show abstract

Prevalence of Type 2 Diabetes, Impaired Fasting Glucose, and Diabetes Risk in an Adult and Older North-Eastern Portuguese Population

Cited by 3 publications

References 46 publications

Diabetes Mellitus across the Arabo-Islamic World: A Revolution

Diabetes Mellitus across the Arabo-Islamic World: A Revolution

Risk stratification of type 2 diabetes in the Russian population depending on FINDRISC category: results of prospective follow-up

Genetic Predisposition to Prediabetes in the Kazakh Population

Contact Info

Product

Resources

About