Prevalence of type‐specific HPV infection in Uruguay

Berois, Nora; Heard, Isabelle; Fort, Zoraida; Alonso, Rafael; Sica, Adela; Moerzinger, Patricia; Rodríguez, Guillermo; Sancho‐Garnier, H.; Osinaga, Eduardo; Favre, Michel

doi:10.1002/jmv.23870

Cited by 16 publications

(24 citation statements)

References 18 publications

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“…Despite being a genotype frequently reported in high‐grade lesions and invasive carcinoma, HPV45 was not common in our cohort of patients. Similar to our results, in a study with a cohort of patients from the national program for cervical cancer prevention in Uruguay and using PapilloCheck ® platform, HPV45 was only reported in 6.6% of patients with HSIL . Therefore, we favor the view that subtle differences across the several studies are probably related to the different population selection method, sampling method but especially due to the severity of lesion present.…”

Section: Discussionsupporting

confidence: 88%

Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL

Beça

Pinheiro

Rios

et al. 2014

Diagnostic Cytopathology

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The contribution of human papillomavirus (HPV) types to the carcinogenesis of cervical cancer has been established for a long time. However, the role of phylogenetically related and rare variants remains uncertain, as well as the influence of concurrent multiple HPV genotypes infection. We aimed at studying the prevalence of several HPV genotypes infecting women with single versus concurrent multiple HPV genotypes infection with a HSIL diagnosis in a cervical cytology. We conducted a cross-sectional study using Thin-Prep(®) liquid-based cervical cytology specimens with the diagnosis of high-grade squamous intraepithelial lesion (HSIL), in which HPV genotype was sequentially tested. Genotypes were determined with a PapilloCheck(®) system, a DNA-Chip for the type-specific identification of 18 high-risk and six low-risk types of HPV. Of the total study population, 176 cases had a diagnosis of HSIL and positive HPV genotyping result, being HPV16 the most prevalent genotype (48.86%; 95%CI: 41.58-56.19) followed by HPV31 (14.20%; 95%CI: 9.75-20.18). Concurrent multiple HPV genotypes were detected in 36.93% (95%CI: 30.15-44.27) of the patients. The prevalence of the 10 most common HPV genotypes detected varied significantly according to the presence of single vs. concurrent multiple HPV genotypes (P = 0.022). Moreover, women with concurrent multiple HPV genotypes were on average 3.53 (95%CI: 0.43-6.64) years younger than women with single genotype infection. Our results suggest that women with multiple genotype HPV infection differ in terms of age and distribution of the most prevalent HPV genotypes. Additionally, we provide further evidence of the predominance of HPV16 in HSIL lesions of the uterine cervix.

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Section: Discussionsupporting

confidence: 88%

Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL

Beça

Pinheiro

Rios

et al. 2014

Diagnostic Cytopathology

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“…En conjunto HPV 16 y/o 18 fueron el 6.3 % del total de las muestras, El HPV 16 fue el genotipo más frecuente (3.6%). Los autores concluyen que estos datos son de relevancia en relación a la cobertura de las vacunas (87) . Un artículo previo al anterior exploró el perfil de genotipos en tumores invasores de CCU, encontrando la infección por HPV en casi el 93% de las muestras, siendo el perfil de genotipos más frecuentes los siguientes: HPV 16 (67.6%),…”

Section: Anfamed -Issn: 2301-1254unclassified

Cáncer: magnitud del problema en el mundo y en Uruguay, aspectos epidemiológicos

Barrios¹,

Garau²

2017

An Facultad Med (Univ Repúb Urug)

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ResumenEl problema del cáncer es uno de los desafíos más relevantes de nuestra época. Como consecuencia de la transición demográfico-epidemiológica, el cáncer es actualmente una de las principales causas de muerte en el mundo y en Uruguay. Debido a que esta transición está aún en curso y con diferentes diná-micas alrededor del mundo, el problema del cáncer está cambiando en su escala y perfil. Se estima que el número de casos nuevos anuales pasará de alrededor de 14 millones en 2012 a más de 20 millones en 2030, y que casi dos tercios de esos casos ocurrirán en los países menos desarrollados. En tanto que estos últimos no cuentan con recursos similares a aquellos de los países desarrollados para enfrentar la enfermedad, esta situación plantea un desafío dramático para gobiernos y autoridades sanitarias.En Uruguay se diagnostican unos 13000 casos nuevos de cáncer (exceptuando al cáncer de piel distinto al melanoma), y más de 8000 pacientes mueren por esta enfermedad anualmente. Se examina, en particular, la situación epidemiológica de los cuatro tipos de cáncer más importantes: el cáncer de mama femenino, y los de próstata, pulmón y colo-recto, éstos dan cuenta de la mitad del total. Se analizan, además: el cáncer cervico-uterino y el cáncer de esófago. Las tasas estandarizadas por edad de mortalidad por cáncer (todos los sitios reunidos) muestran un descenso sostenido en las últimas décadas. No obstante, Uruguay exhibe en general tasas de incidencia comparables al conjunto de los países desarrollados, pero tasas de mortalidad más elevadas. Palabras claveCáncer, incidencia, mortalidad, epidemiología, Uruguay. AbstractThe burden of cancer is one of the most relevant challenges of our time. As a consequence of the demographic-epidemiologic transition, cancer is currently one of the leading causes of death, globally and in Uruguay. This transition is still in progress but with different dynamics around the world; therefore, the burden of cancer is changing its scale and profile. The projections indicate that the number of new cases will grow from 14 million in 2012 to more than 20 million in 2030, and that almost two thirds of them will take place in developing countries. Since less developed countries don`t have

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“…Upon comparing this prevalence of high‐risk HPV infection with the six literature articles in the general population, there was a statistically significant difference between the value found in the study (40%) with five results.…”

Section: Resultsmentioning

confidence: 65%

Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients

Martins

Guimarães

Velarde

2017

Transplant Infectious Dis

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The high prevalence of HPV infection and its precursor lesions confirmed the importance of differential screening and follow-up of transplanted patients. Condom use must be encouraged. The study result also confirmed the importance of knowledge of the viral type, in order to analyze the impact of HPV immunization, particularly against HPV types that are not 16/18. The reasonable rate of other genotypes, besides the vaccine types, should be considered to evaluate vaccination strategies.

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Prevalence of type‐specific HPV infection in Uruguay

Cited by 16 publications

References 18 publications

Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL

Genotypes and prevalence of HPV single and multiple concurrent infections in women with HSIL

Cáncer: magnitud del problema en el mundo y en Uruguay, aspectos epidemiológicos

Relationship between the risk factors for human papillomavirus infection and lower genital tract precursor lesion and cancer development in female transplant recipients

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