Prevalência de megas em necrópsias realizadas no triângulo mineiro no período de 1954 a 1988

The Chronic Gastrointestinal Manifestations of Chagas Disease

“…Chagasic achalasia and its consequence of chagasic megaesophagus are common findings in Chagas disease, and dysphagia may be the first symptom of digestive disturbances that may lead to malnutrition and severe weight loss 8,9,35,39,40…”

“…Chronic constipation is the main symptom related to megacolon 4,6,8,35. Although chagasic megacolon presents with symptoms and radiological findings similar to congenital megacolon, differences are also related to damage in both excitatory and inhibitory innervations 19,20,22,24,25.…”

Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease

“…The heart pathology is characterized by chronic myocarditis that frequently leads to cardiomegaly, congestive heart failure and arrhythmias (Tanowitz 1992). In the digestive forms of the disease, dilatation of the esophagus and/or colon (megaesophagus and megacolon, respectively) may be observed in advanced stages (Lopes et al 1989, Adad et al 1991. Pathologically, both the heart and digestive tract exhibit focal lymphocytic infiltrates (Brener 1992), with scarring and loss of myocardial cells in the cardiopathy (Palacius-Pru et al 1989) and neuronal degeneration with denervation in megaesophagus and megacolon (Köeberle, 1968, Adad et al 1991.…”

Caracterização radiográfica das manifestações esofagogastrointestinais da doença de Chagas

“…Verifica-se aumento do diâmetro das vísceras ocas em proporção ao estádio evolutivo da afecção. O cólon é o mais freqüentemente acometido, seguido pelo esôfago e pela associação megacólonmegaesôfago (3) . A caracterização radiológica baseia-se predominantemente nas chamadas "megaformações".…”