Prevalência dos fatores trombofílicos em mulheres com infertilidade

Soligo, Adriana de Góes e Silva; Barini, Ricardo; Carvalho, Egle Cristina Couto de; Annichino‐Bizzacchi, Joyce Maria

doi:10.1590/s0100-72032007000500003

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…As trombo-filias têm sido identifi cadas com maior frequência em mulheres com falha de implantação submetidas a repetidos ciclos de FIV, quando comparadas com mulheres férteis 45 . A trombofilia também tem sido associada à síndrome de hiperestímulo ovariano (SHO), que ocorre quando há uma resposta ovariana exacerbada após uso de indutores de ovulação, muito utilizada nos procedimentos de FIV 43 .…”

Section: Discussionunclassified

Abordagem laboratorial das síndromes antifosfolípide e do aborto recorrente

Sanches¹,

Caputto²,

Fonseca³

et al. 2010

Arq. Bras. Ciên. Saúde

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Um aumento no potencial hemostático endometrial ocorre durante o ciclo menstrual, possibilitando, assim, a implantação embrionária, caso ocorra a fertilização. Defeitos nas proteínas de coagulação podem alterar esse estado de hipercoagulabilidade gestacional e desencadear perdas fetais por falhas na implantação ou na nutrição do embrião. A síndrome do aborto recorrente pode ser ocasionada por inúmeros fatores, entre eles anormalidades cromossômicas, anatômicas ou hormonais, ou ainda por defeitos nas proteínas de coagulação sanguínea ou plaquetária. Uma causa comum de abortos recorrentes é a síndrome antifosfolípide, uma desordem sistêmica, autoimune, caracterizada por trombose arterial e/ou venosa, morte fetal, abortos recorrentes e trombocitopenia, acompanhada de títulos elevados de anticorpos antifosfolípides: anticoagulante lúpico e/ou anticardiolipina. Pela íntima associação dessas síndromes, faz-se necessário investigá-las em pacientes que procuram os tratamentos de fertilização in vitro. Palavras-chave: Síndrome antifosfolipídica; aborto habitual; inibidor de coagulação do lúpus; anticorpos anticardiolipina.

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Section: Discussionunclassified

Abordagem laboratorial das síndromes antifosfolípide e do aborto recorrente

Sanches¹,

Caputto²,

Fonseca³

et al. 2010

Arq. Bras. Ciên. Saúde

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“…The infertile women were selected by reviewing the files of patients attending a private clinic between March 2003 and March 2005. 10 All of the women were Caucasian and aged over 18 years, with primary and unexplained infertility. Male or tubal factors were excluded.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of the MTHFR C677T Mutation in Fertile and Infertile Women

Soligo

Barini

Annichino‐Bizzacchi

2017

Rev Bras Ginecol Obstet

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Introduction The importance of the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in infertile women remains controversial. Objective To evaluate if the MTHFR C677T mutations are more frequent in infertile women, and if they can be associated with the occurrence of infertility in the Brazilian population. Methods This case-control study included 130 infertile women consulting at a private clinic between March 2003 and March 2005 (data previously published), and 260 fertile women attending the family planning outpatient clinic of our institution between April 2012 and March 2013. Data analysis The Chi-squared and Fisher Exact tests were used to evaluate the association between the presence of the MTHFR C677T mutation and a history of infertility. Results The frequency of the mutation was of 58.5% for the case group (n ¼ 76) and of 49.2% for the fertile controls (n ¼ 128). The mutation was homozygous in 13 women in the case group (10%) and in 23 of the fertile women in the control group (8.8%). These differences were not statistically significant. Conclusions These results suggest that the presence of the MTHFR C677T mutation does not constitute a risk factor for infertility, even when the mutation is homozygous. Further studies are needed to confirm whether research on this mutation should be considered unnecessary in women with infertility.

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“…15,19 Other authors have shown that 40% of factors leading to infertility are found in men, of which 15% on average have an unknown cause. 20,21 Other studies have shown that the female and male factors correspond to 30% each, with 10% of these having an unexplained cause. 22 The causes of infertility linked to the ovaries are equivalent to about 10 to 20% of infertility in developed countries.…”

Section: In Vitro Fertilization (Ivf) X Polycystic Ovarian Syndrome (mentioning

confidence: 98%

The influence of polycystic ovarian syndrome on in vitro fertilization

Lopes¹,

Alves²,

Magalhães-Padilha³

2019

Hum. Reprod. Arch.

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Objectives:The aim of the current article was to review data already published in the literature on Polycystic Ovarian Syndrome associated with infertility. Methods: Search for scientific articles in the databases: Lilacs, SciELO, Medline, Pubmed, Elsevier and Virtual Health Library, from 2001 to 2017, as well as bibliographies present at Potiguar University. Results: Polycystic Ovarian Syndrome is a hormonal disorder that affects a large part of the female population of reproductive age. The main cause of this disorder is hyperandrogenism, which together with oligoanovulation adds more characteristic factors for the diagnosis of this pathology. Hyperandrogenism is characterized by an excessive production of androgen hormones, with this production being discerned by a marked synthesis of testosterone, which is stimulated by the luteinizing hormone and intensified by insulin or by the intrinsic elevation of the secretion of these androgens. Although this pathology is recognized mainly by androgenic elevation, its hormonal action is still unknown. However, studies indicate that the high catabolism of cortisol and the intense response of adrenal androgens to normal adrenocorticotrophic hormone levels are related. Assisted human reproduction (AHR) has been an option to treat infertility due to Polycystic Ovarian Syndrome (PCOS); however it presents, mixed results. Due to the importance of this subject and the absence of recent articles relevant to the topic, the aim of this article was to review the published data on the PCOS associated with infertility. conclusions: In vitro fertilization is an option to achieve pregnancy in women refractory to treatment with ovulation stimulants. Despite few studies linking Polycystic Ovarian Syndrome with in vitro fertilization, it was found that this biotechnology provides significant results, however it may present subsequent disorders.

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Prevalência dos fatores trombofílicos em mulheres com infertilidade

Cited by 7 publications

References 14 publications

Abordagem laboratorial das síndromes antifosfolípide e do aborto recorrente

Abordagem laboratorial das síndromes antifosfolípide e do aborto recorrente

Prevalence of the MTHFR C677T Mutation in Fertile and Infertile Women

The influence of polycystic ovarian syndrome on in vitro fertilization

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