Objective Between 2010 and 2017, it was registered one of the most intense droughts in the Brazilian Northeastern Semiarid region, when the rainfall was below the historical level for the region. This context was related to water scarcity for human consumption and productive activities in this territory, where the semiarid backlands of the state of Pernambuco are located. The objective of this study was to assess the condition of food security and its associated factors in areas affected by drought in the semiarid zone of Pernambuco, Brazil. Methods It was a cross-sectional study on a populational base. Data were collected by socioeconomic and demographic surveys, and the Brazilian Food Insecurity Scale, which were applied to 252 households, from September to October 2015. The data was analyzed by socioeconomic and demographic characterization of the households, and the identification of the food insecurity prevalence and its associated factors, by Poisson regression. Results The prevalence of food insecurity was high (74.6%). Among those, 9,1% were on starvation, which means severe insecurity. Food insecurity was statistically associated to sanitation, per capita income, and the number of household residents. Lack of money was the main self-reported cause to food insecurity. Conclusion The high prevalence of food insecurity being associated to indicators of great social vulnerability shows the role of social and economic inequities on the inadequate access to food amongst families in the semiarid zone on a nearly generalized low-income context. These findings corroborate to the evident need of expanding and reinforcing public policies, as well sustainable development models to prioritize and promote social inclusion of communities at greater vulnerabilities in the Brazilian semiarid area. Thus, the need of these economic and social public strategies is highlighted by the worsening of historical vulnerable conditions due to the cycles of droughts on this region.