Prevention and management of antineoplastic therapy induced oral mucositis

Bey, Afshan; Ahmed, Sheikh Salahuddin; Hussain, Bilal; Devi, Seema; Hashmi, Sarwat H.

doi:10.4103/0975-5950.79214

Cited by 14 publications

(4 citation statements)

References 47 publications

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“…Для уменьшения болевых ощущений и сокращению длительности осложнения, рекомендуют использование оральной криотерапии во время химиотерапии [64]. Предлагаемая методика заключается в расположении кусочков льда в полость рта пациентов в момент внутривенного введения 5-фторурацила и нахождении их в полости рта в течение 10 минут -периода полураспада препарата в плазме крови [9]. Предполагается, что сужение сосудов уменьшит приток крови к клеткам СоПр и таким образом снизится поступление препарата.…”

Section: местные осложнения при лучевом и химиотерапевтическом лечени...unclassified

Local Complications of Radiation and Chemotherapy Treatment of Patients With Squamous Cell Carcinoma of the Mucosa of the Oral Cavity

Kochurova¹,

Mukhanov²

2018

Problems in oncology

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Question on comprehensive dental care to patients with squamous cell carcinoma (SCC) of the mucous membrane of the oral cavity (MMOC) showed the importance of a team approach of physicians of allied specializations, careful planning and consistent implementation of rehabilitation treatment stages of cancer. The implementation of preventive measures showed a reduced severity or absence of complications conducted by the primary treatment. The data about the important role of preoperative sanitation of the oral cavity are presented. There are described the pathogenesis of the most common complications and identified effective methods of prevention and treatment, as well as the mechanisms of action of different prevention methods. Characteristic signs of “radiation caries”, oral mucositis, dysgeusia, xerostomia, lockjaw chewing muscles, osteoradionecrosis, dysphagia and neurotoxic effects of chemotherapy drugs are marked. It is necessary to emphasize the considerable effect of such complications on quality of life of patients after treatment. This again proves a need for an integrated approach and participation in the work of the specialists of a number of related disciplines.

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Section: местные осложнения при лучевом и химиотерапевтическом лечени...unclassified

Local Complications of Radiation and Chemotherapy Treatment of Patients With Squamous Cell Carcinoma of the Mucosa of the Oral Cavity

Kochurova¹,

Mukhanov²

2018

Problems in oncology

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“…Recently, Silva et al [ 30 ] tested a soft pastille formulation consisting of 0.25% lidocaine and 78,000 IU Nystatin, which was found to facilitate accurate drug administration by physicians and to enable patients to control drug retention time in the mouth in order to manage the pain treatment process. On the other hand, chlorhexidine is an effective broad-spectrum antiplaque antiseptic agent [ 31 ]. However, these drugs are not very effective in reducing the severity or incidence of mucositis [ 32 , 33 ].…”

Section: Mucositis Managementmentioning

confidence: 99%

Oral Mucositis: Melatonin Gel an Effective New Treatment

Moneim

Guerra‐Librero

Florido

et al. 2017

IJMS

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The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients’ lives.

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“…Chemotherapy dose and patient hygiene affect the severity of the lesion. This lesion appears 7 to 10 days after the treatment begins, and spontaneously disappears 2 to 4 weeks after the treatment ends (Bey et al 2010).…”

Section: Introductionmentioning

confidence: 97%

A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial

Samiraninezhad,

Rezaee,

Gholami

et al. 2023

Inflammopharmacol

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ObjectivesConsidering the prevalence of oral mucositis, we aimed to use the analgesic effects of doxepin with antimicrobial and bio-adhesive nature of chitosan to fabricate a nano-formulation for treatment of chemotherapy-induced oral mucositis. Materials and MethodNanogel was fabricated via ionic gelation and characterized. Sixty patients were randomly divided and received four different treatments for 14 days: diphenhydramine + aluminum-magnesium mouthwash (control), doxepin mouthwash (DOX MW), chitosan nanogel (CN), and doxepin/chitosan nanogel (CN + DOX). Lesions were assessed with four indices, national cancer institute (NCI), world health organization (WHO), and corld conference on clinical and research in nursing (WCCNR) and visual analogue scale (VAS) before and 3, 7, and 14 days after interventions. Kruskal Wallis test was used for pairwise comparison. ResultsCN had semisolid consistency, uniform spherical shape, an average size of 47.93 ± 21.69 nm and a zeta potential of + 1.02 ± 0.16 mV. Three days after intervention CN + DOX reduced WHO, WCCNR and VAS scores signi cantly more than control. Seven days after intervention CN + DOX reduced NCI and WCCNR signi cantly more than control; and it reduced WCCNR signi cantly more than CN. Fourteen days after intervention CN + DOX reduced NCI signi cantly more than control. ConclusionChitosan-based doxepin nano-formulation might be a promising alternative for routine treatments of oral mucositis.

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Prevention and management of antineoplastic therapy induced oral mucositis

Cited by 14 publications

References 47 publications

Local Complications of Radiation and Chemotherapy Treatment of Patients With Squamous Cell Carcinoma of the Mucosa of the Oral Cavity

Local Complications of Radiation and Chemotherapy Treatment of Patients With Squamous Cell Carcinoma of the Mucosa of the Oral Cavity

Oral Mucositis: Melatonin Gel an Effective New Treatment

A novel chitosan-based doxepin nano-formulation for chemotherapy-induced oral mucositis: a randomized, double-blinded, placebo-controlled clinical trial

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