Prevention is better than cure: The role of infection prevention in the control of antimicrobial resistance

Kiernan, Martin

doi:10.1177/1757177417739116

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…The adage that “prevention is better than cure” is especially true regarding antibiotic resistance because the resistance is introduced and spread much faster than the production of new antibiotics [ 14 , 15 ]. Vaccination is an important strategy to fight infectious agents; however, this strategy has not attracted sufficient attention in antibiotics resistance prevention.…”

Section: Introductionmentioning

confidence: 99%

In silico vaccine design and epitope mapping of New Delhi metallo-beta-lactamase (NDM): an immunoinformatics approach

Fathollahi

Motamedi

et al. 2021

BMC Bioinformatics

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Background Antibiotic resistance is a global health crisis. The adage that “prevention is better than cure” is especially true regarding antibiotic resistance because the resistance appears and spreads much faster than the production of new antibiotics. Vaccination is an important strategy to fight infectious agents; however, this strategy has not attracted sufficient attention in antibiotic resistance prevention. New Delhi metallo-beta-lactamase (NDM) confers resistance to many beta-lactamases, including important carbapenems like imipenem. Our goal in this study is to use an immunoinformatics approach to develop a vaccine that can elicit strong and specific immune responses against NDMs that prevent the development of antibiotic-resistant bacteria. Results In this study, 2194 NDM sequences were aligned to obtain a conserved sequence. One continuous B cell epitope and three T cell CD4+ epitopes were selected from NDMs conserved sequence. Epitope conservancy for B cell and HLA-DR, HLA-DQ, and HLA-DP epitopes was 100.00%, 99.82%, 99.41%, and 99.86%, respectively, and population coverage of MHC II epitopes for the world was 99.91%. Permutation of the four epitope fragments resulted in 24 different peptides, of which 6 peptides were selected after toxicity, allergenicity, and antigenicity assessment. After primary vaccine design, only one vaccine sequence with the highest similarity with discontinuous B cell epitope in NDMs was selected. The final vaccine can bind to various Toll-like receptors (TLRs). The prediction implied that the vaccine would be stable with a good half-life. An immune simulation performed by the C-IMMSIM server predicted that two doses of vaccine injection can induce a strong immune response to NDMs. Finally, the GC-Content of the vaccine was designed very similar to E. coli K12. Conclusions In this study, immunoinformatics strategies were used to design a vaccine against different NDM variants that could produce an effective immune response against this antibiotic-resistant factor.

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Section: Introductionmentioning

confidence: 99%

In silico vaccine design and epitope mapping of New Delhi metallo-beta-lactamase (NDM): an immunoinformatics approach

Fathollahi

Motamedi

et al. 2021

BMC Bioinformatics

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“…IPC is relevant for all types of infections, and plays an important role in limiting the acquisition and transmission of AMR organisms (Kiernan, 2017;Price et al, 2017). IPC programs were introduced in healthcare facilities in the 1950s as a response to Staphylococcus aureus outbreaks that were associated with substantial mortality (Scheckler et al, 1998;Forder, 2007).…”

Section: Infection Prevention and Controlmentioning

confidence: 99%

An Update on the Ocular Surface Bacterial Microbiota in Small Animals

Leis¹

2023

Veterinary Clinics of North America: Small Animal Practice

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Prevention is Better than Cure: Antibiotic Resistance and Management of Infectious Diseases Homo sapiens are enjoying a better-quality life for the last seven to eight decades because of the invention of antimicrobials that have successfully treated many bacterial, viral, fungal, protozoan, parasitic diseases around the globe. 1 The easy availability of an antibiotic has promoted a lot of overuse of this important remedial agent called 'miracle drugs' 2 all over the world, especially in lower and middle-income countries (LMICs), where, at many occasions' antimicrobials are often sold over the counter without any prescription. 3 Additionally, the World Health Organization reported that around 50% of antibiotics consumption is without any definite clinical need or irrationally or imprudent.

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mentioning

confidence: 99%

“…Additionally, the situation getting worse because almost no new antimicrobials are in the pipeline to appear in the market very soon to counter the AMR. 1,8,9 Currently, the situation AMR is horrifying as almost all available antibiotics or antimicrobials for clinical use are resistant. Even the last resort for infectious diseases the colistin similarly resistant.…”

mentioning

confidence: 99%

Prevention is Better than Cure: Antibiotic Resistance and Management of Infectious Diseases

Haque

2020

Int. J. Hum. Health Sci.

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Prevention is better than cure: The role of infection prevention in the control of antimicrobial resistance

Cited by 3 publications

References 9 publications

In silico vaccine design and epitope mapping of New Delhi metallo-beta-lactamase (NDM): an immunoinformatics approach

In silico vaccine design and epitope mapping of New Delhi metallo-beta-lactamase (NDM): an immunoinformatics approach

An Update on the Ocular Surface Bacterial Microbiota in Small Animals

Prevention is Better than Cure: Antibiotic Resistance and Management of Infectious Diseases

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