Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix Antiasthmatic decoction

Xu, Su Xiu; Tian, Bo; Zhang, Lan-Hong; Huang, Wen; Xia, Li-Xia; Chen, Zhihua; Li, Wen; Shen, Huahao

doi:10.1186/1472-6882-13-369

Cited by 14 publications

(6 citation statements)

References 25 publications

(25 reference statements)

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“…In this study, there was a significant recovery of goblet cell hyperplasia, thickness of the collagen layer, and the VEGF signaling pathway in BAW-treated groups. These findings are similar to those of previous in vivo studies in which numerous natural products, including Vitex rotundifolia L. [ 41 ], Astragali radix Anti-Asthmatic Decoction [ 42 ], Bangpungtongseong-san [ 43 ], and Suhuang antitussive capsule [ 44 ], were reported to induce the stimulation of airway remodeling in OVA-treated BALB/c mice. However, the preventive effects of fermented natural products against airway remodeling have never been investigated in an OVA-induced asthma model.…”

Section: Discussionsupporting

confidence: 91%

The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model

Choi

Kim

Park

et al. 2018

JCM

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Introduction: Roots of Asparagus cochinchinensis, which have pharmacologically active ingredients, have received great attention because they show good therapeutic effects for various inflammatory diseases without specific toxicity. This study investigated the anti-asthmatic effects of a butanol extract of Asparagus cochinchinensis roots that had been fermented with Weissella cibaria (BAW) and its possible underlying cholinergic regulation. Methods: Alterations of the anti-asthmatic markers and the molecular response factors were measured in an ovalbumin (OVA)-induced asthma model after treatment with BAW. Results: Treatment with BAW decreased the intracellular reactive oxygen species (ROS) production in lipopolysaccharides (LPS) activated RAW264.7 cells. The results of the animal experiments revealed lower infiltration of inflammatory cells and bronchial thickness, and a significant reduction in the number of macrophages and eosinophils, concentration of OVA-specific IgE, and expression of Th2 cytokines in the OVA + BAW treated group. In addition, a significant recovery of goblet cell hyperplasia, MMP-9 expression, and the VEGF signaling pathway was observed upon airway remodeling in the OVA + BAW treated group. Furthermore, these responses of BAW were linked to recovery of acetylcholine esterase (AChE) activity and muscarinic acetylcholine receptor (mAChR) M3 downstream signaling pathway in epithelial cells, smooth muscle cells, and afferent sensory nerves of OVA + BAW-treated mice. Conclusion: Overall, these findings are the first to provide evidence that the therapeutic effects of BAW can prevent airway inflammation and remodeling through the recovery of cholinergic regulation in structural cells and inflammatory cells of the chronic asthma model.

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Section: Discussionsupporting

confidence: 91%

The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model

Choi

Kim

Park

et al. 2018

JCM

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“…One possible reason could be the presence genetically dominant Th2 immune responses in BALB/c mice. [31][32][33] Moreover, Th2-produced IL-4 induces asthma features including recruitment of inflammatory cells into the airways and bronchial inflammation 3,5,30,34 In our experiment, OVA mice showed higher levels of Th2related cytokine IL-4, total WBC number and eosinophil percentages and obvious peribronchial inflammation compared to normal non-sensitized mice which confirmed an effective asthma modeling. However, lymphocyte percentage in OVA control animals was reduced compared to normal control animals (Figure 2C).…”

Section: Discussionsupporting

confidence: 69%

Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma

Harati

Bahrami

Razavi

et al. 2018

IJAAI

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Asthma is a chronic inflammatory disease of the lungs driven by T cell activation. Viola tricolor L. as a traditional medical herb could suppress activated T lymphocytes and has been used empirically for asthma remedy. In the present study, we investigated the anti-inflammatory effect of Viola tricolor and its underlying mechanism on asthma characteristics induced by ovalbumin (OVA) in mice. BALB/c mice were randomly divided into six groups: normal control, Ovalbumin (OVA) control, OVA mice treated with Viola tricolor (50, 100 and 200 mg/kg) and dexamethasone (3 mg/kg). All mice except normal controls were sensitized and challenged with OVA. Asthmatic mice were treated orally in the last 7 days of OVA challenge. The total and differential leukocyte counts, Interleukin (IL)-4 and interferon (IFN)-γ levels in bronchoalveolar lavage fluid (BALF) were determined. H&E staining for lung inflammation was performed. Viola tricolor treatment at 200 mg/kg significantly decreased IL-4 level but did not considerably affect the IFN-γ level. Therefore, it effectively reduced asthma characteristics including infiltration of leukocytes particularly eosinophil and peribronchial inflammation as compared to dexamethasone. However, Viola tricolor at 100 mg/kg had the most prominent inhibitory effect on the IL-4 level and also markedly increased IFN-γ level. As result, it prevented further reduction of inflammatory parameters in this group compared to the Viola tricolor-treated group at 200 mg/kg. Our study demonstrated that Viola tricolor has anti-inflammatory effects via inhibition of T-helper type 2 (Th2) cytokine production and validated its empirical usage in traditional medicine.

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“…IL-13 was reported to be the crucial mediator in eosinophil induced airway AHR and mucus production 16 23 24 . Previous studies including our investigations found that IL-13 down-regulation remit airway inflammation and AHR, as well as mucus production 25 26 . In our present study, we observed a significantly decreased IL-13 level in lung homogenates of Suhuang treatment groups, which should contribute to the overall protective effects in the asthma model.…”

Section: Discussionmentioning

confidence: 48%

“…TGF-β1 also induces proliferation, survival and extracellular matrix (ECM) secretion in ASMCs, suggesting a possible cause of increased thickness of airway tissues 15 . Inhibition of TGF-β1 including with traditional Chinese medicine could improve asthmatic symptom 26 31 32 33 . We demonstrated that Suhuang effectively attenuated TGF-β1 expression induced by chronic allergen exposure.…”

Section: Discussionmentioning

confidence: 99%

Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation and remodeling in a murine model of chronic asthma

Zhang

et al. 2016

Sci Rep

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Suhuang antitussive capsule (Suhuang), a traditional Chinese medication, is found effective in treating chronic cough and cough variant asthma (CVA). This study aimed to determine the possible effects and underlying mechanisms of Suhuang on chronic ovalbumin (OVA)-induced airway hyperresponsiveness (AHR), inflammation, and remodeling in mice. Mice were randomly assigned to six experimental groups: control, OVA model with or without Suhuang (low dose: 3.5 g/kg, middle dose: 7.0 g/kg, high dose: 14.0 g/kg), or dexamethasone (2.5 mg/kg). AHR, inflammatory cells, cytokines in bronchoalveolar lavage fluid (BALF), lung pathology, mucus production, and airway remodeling were examined. We found Suhuang treated at lower doses effectively inhibited OVA-induced AHR, airway inflammation, mucus production and collagen deposition around the airway. High dose of Suhuang reduced most of the inflammatory hallmarks while exerted inconsiderable effects on the number of macrophages in BALF and AHR. At all doses, Suhuang significantly reduced the levels of interlukin (IL) -13 and transforming growth factor (TGF)-β1, but had little effects on IL-4, IL-5, IL-17A and interferon (IFN)-γ. Thus, Suhuang administration alleviates the pathological changes of chronic asthma likely through inhibition of IL-13 and TGF-β1. Suhuang might be a promising therapy for patients with allergic asthma in the future.

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Prevention of allergic airway hyperresponsiveness and remodeling in mice by Astragaliradix Antiasthmatic decoction

Cited by 14 publications

References 25 publications

The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model

The Anti-Inflammatory Effects of Fermented Herbal Roots of Asparagus cochinchinensis in an Ovalbumin-Induced Asthma Model

Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma

Suhuang antitussive capsule at lower doses attenuates airway hyperresponsiveness, inflammation and remodeling in a murine model of chronic asthma

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