Prevention of deep vein thrombosis after hip replacement: randomised comparison between unfractionated heparin and low molecular weight heparin.

The Incidence of Heparin Induced Thrombocytopenia in Orthopedic Surgery Patients in Khartoum, Sudan

“…These results are consistent with previous studies in international literature, in which platelet counts have been monitored in several large clinical trials that compared UFH with LMWH as antithrombotic prophylaxis after hip surgery or for the treatment of deep venous thrombosis [16]. The investigators found that HIT occurred in 2 out of 199 patients (1.0%) who received UFH after hip-replacement surgery, as compared with none of 198 patients who received LMWH; both patients with thrombocytopenia also had proximal deep venous thrombosis [17].…”

Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

“…Fifteen articles were eligible for analysis (Table 1) and were grouped into 3 categories, as follows: 2 RCTs measuring HIT as an outcome 3,11 ; 3 nonrandomized prospective studies with a comparison group (concurrent or sequential control group) and measuring HIT as an outcome 12-14 ; 10 RCTs not measuring HIT but appropriately monitoring thrombocytopenia as an outcome. [15][16][17][18][19][20][21][22][23][24] We performed 3 different analyses.…”

A prospective randomized study on the use of nadroparin calcium in the prophylaxis of thromboembolism in Korean patients undergoing elective total hip replacement

“…In our study the ratio of proximal to calf DVT in the placebo group was 1 : 1.6. By contrast, in European and North American studies the ratio was 1 : 4 in patients receiving LMWH prophylaxis [3,7].…”

“…From the 4th to the 10th days after operation the dosage was increased to 62 IU/kg per single subcutaneous injection. This regime is similar to that used by Leyvraz et al [7], and is the dose recommended by the manufacturer.…”

“…This prompted us to study the efficacy of a LMWH in preventing DVT in Korean patients undergoing elective total hip replacement. Previous studies have shown LMWH to be effective in preventing DVT and, in particular, proximal deep vein thrombosis in such patients [3,6,7,10]. …”