Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: A randomized, double‐blind, placebo‐controlled trial

Fujii, Yoshitaka; Tanaka, Hiroyoshi; Toyooka, Hidenori

doi:10.1111/j.1399-6576.1998.tb05350.x

Cited by 43 publications

(19 citation statements)

References 12 publications

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“…13,14 We believe this is why the incidence of nausea in the sodium-citrate-treated patients (7-37%) was lower than the incidence reported in other studies (63-76%). 6,7 The results of our study differ from those of the only other randomized study on this subject. Palmer et al found that oral Bicitra® did not affect the incidence of nausea during Cesarean delivery.…”

Section: Discussioncontrasting

confidence: 97%

“…[3][4][5] Although sodium citrate is commonly used, many patients dislike its taste and some patients complain of nausea. 6,7 We hypothesized that women having elective Cesarean delivery under spinal anesthesia would have a higher incidence of nausea when receiving sodium citrate rather than water and famotidine immediately prior to surgery. We designed a randomized trial to test this hypothesis.…”

Section: Objectifmentioning

confidence: 99%

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Oral sodium citrate increases nausea amongst elective Cesarean delivery patients

et al. 2006

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Purpose: Historically, aspiration of gastric contents with subsequent pneumonia was a major cause of anesthesia-related maternal mortality. Before elective Cesarean delivery, gastric fluid can be neutralized with histamine-2 blockers or with oral sodium citrate. Although sodium citrate is commonly used, many patients dislike its taste. We designed this study to determine whether or not patients are more likely to experience nausea during Cesarean delivery when sodium citrate is administered preoperatively. Methods:One hundred and twenty-three healthy women carrying a singleton fetus and scheduled for elective Cesarean delivery under spinal anesthesia were randomized to receive either sodium citrate 30 mL po and saline 2 mL iv (sodium citrate group), or water 30 mL po and famotidine 20 mg iv (famotidine group). Spinal anesthesia consisted of 1.6 mL of 0.75% bupivacaine (12 mg), fentanyl 20 µg, and preservativefree morphine 200 µg. Patients were asked to rate the degree of nausea present at one and five minutes after spinal placement, at the time of uterine exteriorization, and upon arrival to the recovery room. At each time point, the patient's systolic blood pressure and heart rate were recorded. Results:At all recorded intervals, the average degree of nausea was greater in the sodium citrate group compared to the famotidine group. The frequency of nausea was also greater in the sodium citrate group compared with the famotidine group (37% vs 14% respectively, P < 0.05) five minutes after establishment of spinal anesthesia. The frequencies of nausea were not significantly different between groups at other time periods.Conclusion: Nausea is more common during Cesarean delivery in women who receive oral sodium citrate rather than iv famotidine for aspiration prophylaxis. Objectif

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Section: Discussioncontrasting

confidence: 97%

Section: Objectifmentioning

confidence: 99%

Oral sodium citrate increases nausea amongst elective Cesarean delivery patients

et al. 2006

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“…The incidence of intraoperative postdelivery emetic symptoms was lower in our study (43.8%) than that reported by Fujii et al (63%) [10], but higher than that reported by Baliki et al (17%) [11]. The overall incidence of intraoperative nausea and emesis during regional anesthesia for cesarean section is extremely variable and can reach 79%, depending on the anesthetic technique used and the preventive and therapeutic Fig.…”

Section: Discussioncontrasting

confidence: 77%

“…Nausea and emesis during regional anesthesia for elective cesarean delivery is widespread, with a reported occurrence of 17-80% of patients experiencing a nausea and/or emesis event [1][2][3][4][5][6][7][8][9][10][11]. Metoclopramide and droperidol are commonly administered to reduce nausea and emesis in patients undergoing spinal anesthesia for cesarean section [1][2][3]12].…”

Section: Introductionmentioning

confidence: 99%

Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia

et al. 2011

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“…(7) where incidence of intraoperative nausea and vomiting by prophylactic ondansetron as compared to placebo group was 10% versus 75%; and 20% incidence rate by prophylactic metoclopramide as observed by Fiujii et al (8) Vasanthakumar et al (9) in their study group concluded that injection ondansetron decreases the incidence of emetic episodes than metoclopramide. However, in our study no stastically significance in the incidence of nausea and vomiting could be observed between the two studied drugs.…”

Section: Discussionmentioning

confidence: 96%

Comparision Be T Ween Metoclopramide and Ondansetron for Prevention of Nausea and Vomiting in Caesarean Delivery Under Spinal Anaesthesia

K¹,

Heisnam²,

Lobo³

et al. 2015

jemds

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AIM OF STUDY:To evaluate the anti-emetic efficacy of bolus doses of metoclopramide and ondansetron in preventing nausea and vomiting in caesarean section under spinal anaesthesia. METHODS: Sixty patients of ASA-Ī and ĪĪ undergoing elective caesarean section were randomly divided into 2 groups of 30 each. Group A (n=30) received IV metoclopramide 10mg and Group B (n=30) received IV ondansetron 4mg, 30 minutes prior to spinal anaesthesia. Anaesthetic management was standardized and incidence of nausea, retching and vomiting was compared between the two groups. RESULTS: The maternal characteristics regarding age, weight and gestational period were not significantly different between the two groups. There was also no statistically significant (p>0.05) difference of anti-emetic effects (Nausea, vomiting) between the two studied drugs. CONCLUSION: No single intervention is available to completely eliminate nausea and vomiting. Metoclopramide is as effective as ondansetron in preventing the incidence of nausea and vomiting in caesarean delivery under spinal anaesthesia.

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Prevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: A randomized, double‐blind, placebo‐controlled trial

Cited by 43 publications

References 12 publications

Oral sodium citrate increases nausea amongst elective Cesarean delivery patients

Oral sodium citrate increases nausea amongst elective Cesarean delivery patients

Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia

Comparision Be T Ween Metoclopramide and Ondansetron for Prevention of Nausea and Vomiting in Caesarean Delivery Under Spinal Anaesthesia

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