Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine

Furtado, Kelly Silva; Polletini, Jossimara; Dias, Marianne Camargos; Rodrigues, Maria Aparecida Marchesan; Barbisan, Luı́s Fernando

doi:10.1016/j.fct.2013.11.011

Cited by 34 publications

(36 citation statements)

References 42 publications

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“…In this study, migration and proliferation of stellate hepatic cell were evaluated by various caffeine concentration (0.1 mmol, 1 mmol, 5 mmol, measured using western blot. The result showed that caffeine were played an important tole in inhibiting adhesion and activation process of stellate hepatic cell 16 In this study also showed that F-actin expression and FAK (focal ashesion kinase) were reduce because of caffeine consumption in several periods. F-actin regulate migration, adhesion, and morphological adaptation of stellate hepatic cell, while FAK regulate growth factor stimulation of extracellular matrix.…”

supporting

confidence: 48%

“…This difference were believed as presence of chemoprotective component that differ between various coffee types. 16 Shim et al investigate direct effect of caffeine in stellate hepatic cell and assess whether caffeine model. In this study, migration and proliferation of stellate hepatic cell were evaluated by various caffeine concentration (0.1 mmol, 1 mmol, 5 mmol, measured using western blot.…”

mentioning

confidence: 99%

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Coffee Consumption to Reduce Liver Fibrosis

Utami

Hasan

2015

InaJGHE

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supporting

confidence: 48%

mentioning

confidence: 99%

Coffee Consumption to Reduce Liver Fibrosis

Utami

Hasan

2015

InaJGHE

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“…This inhibitory effect was associated with predominantly a noncompetitive mechanism due to the increased formation of SAH. In a later study, Furtado et al (146) reported that coffee and caffeine significantly inhibited rat liver carcinogenesis.…”

Section: Epigenetic Food Components As Regulators Of Dna Methylation mentioning

confidence: 97%

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

Moreno

Heidor

Pogribny

2016

Nutrition and Cancer

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Hepatocellular carcinoma (HCC) is an aggressive and life-threatening disease often diagnosed at intermediate or advanced stages, which substantially limits therapeutic approaches to its successful treatment. This indicates that the prevention of HCC may be the most promising strategy in reducing its incidence and mortality. Emerging evidence indicates that numerous nutrients and nonnutrient dietary bioactive components can reduce the occurrence and/or delay the development of HCC through modifications of deregulated epigenetic mechanisms. This review examines the existing knowledge on the epigenetic mechanism-based studies in in vitro and in vivo models of HCC on the chemopreventive potential of epigenetic food components, including dietary methyl-group donors, epigallocatechin-3-gallate, sodium butyrate, resveratrol, curcumin, and sulforaphane, on liver carcinogenesis. Future direction and potential challenges in the effective use of bioactive food constituents in the prevention of HCC are highlighted and discussed.

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“…Green tea beverages are enriched with EGCG that have enough potential to inhibit progression and development of HCC via DNA demethylation of abnormally hypermethylated tumor-suppressor genes [162]. Two coffee polyphenols, that is, chlorogenic acid and caffeic acid, inhibited liver carcinogenesis in rat and the inhibition of human DNMT1-mediated enzymatic DNA methylation reaction has also been reported [163, 164]. …”

Section: Nutritional Epigeneticsmentioning

confidence: 99%

New Insights into the Epigenetics of Hepatocellular Carcinoma

Wahid

Ali

Rafique

et al. 2017

BioMed Research International

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Hepatocellular Carcinoma (HCC) is one of the most predominant malignancies with high fatality rate. This deadly cancer is rising at an alarming rate because it is quite resistant to radio- and chemotherapy. Different epigenetic mechanisms such as histone modifications, DNA methylation, chromatin remodeling, and expression of noncoding RNAs drive the cell proliferation, invasion, metastasis, initiation, progression, and development of HCC. These epigenetic alterations because of potential reversibility open way towards the development of biomarkers and therapeutics. The contribution of these epigenetic changes to HCC development has not been thoroughly explored yet. Further research on HCC epigenetics is necessary to better understand novel molecular-targeted HCC treatment and prevention. This review highlights latest research progress and current updates regarding epigenetics of HCC, biomarker discovery, and future preventive and therapeutic strategies to combat the increasing risk of HCC.

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Prevention of rat liver fibrosis and carcinogenesis by coffee and caffeine

Cited by 34 publications

References 42 publications

Coffee Consumption to Reduce Liver Fibrosis

Coffee Consumption to Reduce Liver Fibrosis

Nutritional Epigenetics and the Prevention of Hepatocellular Carcinoma with Bioactive Food Constituents

New Insights into the Epigenetics of Hepatocellular Carcinoma

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