Prevention of selenite-induced cataractogenesis by hydroalchoholic extract of Echium amoenum: An experimental evaluation of the Iranian traditional eye medication

Dailami, Kiumars Noroozpour; Azadbakht, Mohammad; Lashgari, Marjan; Rashidi, Zahra

doi:10.18869/acadpub.pbr.1.4.40

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…In our study, lenses in the sodium selenite group had increased levels of MDA when compared to control group lenses, indicating increased lipid peroxidation in the sodium selenite group. This observation is the same as in our and other previous studies, which reported increased lipid peroxidation upon treatment with sodium selenite [ 12 , 27 , 28 ]. A. officinalis young shoots extract increased the amount of GSH.…”

Section: Discussionsupporting

confidence: 93%

“…In (2015) study, we showed that E. amoenum extract significantly had a protective effect on selenite-induced cataract in rat. This effect is probably associated with the antioxidant activity of this medicinal plant, resulted in inhibiting oxidative stress caused by cataract [ 12 ]. In another experiment, we assessed the preventive effects of Origanum vulgare extract, a potent antioxidant herbal medicine, on selenite-induced cataractogenesis.…”

Section: Introductionmentioning

confidence: 99%

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The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite‐Induced Cataractogenesis in Experimental Animal Models

Azadbakht

Asghari

Dailami

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background and Objectives. Cataract is the leading cause of blindness worldwide. Although surgery is now considered the most successful cure, the development of alternative treatments is needed due to postsurgical complications. Oxidative stress in the lens is considered to be the most crucial factor in the formation of cataracts. Therefore, the effects of the hydroalcoholic extract of Asparagus officinalis L, a traditional antioxidative plant, on cataract formation of sodium selenite were evaluated. Materials and Methods. Neonatal rats received a single dose of sodium selenite as an intraperitoneal injection (30 μmol/kg) on day 10 postnatal to induce cataract. Animals were then posttreated with various oral solutions of A. officinalis extract at 200 mg/kg or 400 mg/kg once daily on days 10–16 postnatal. Cataract was evaluated by slit-lamp, and lens opacification was analyzed in each group 24 hours after the last treatment at day seven postadministration of the extracts or vehicle. The total protein concentration of lenses, glutathione reductase activity as the glutathione antioxidant capacity, and malondialdehyde content as a marker of lipid peroxidation were further assessed in removed rat lenses on day 30 postnatal. Results. All lenses in the healthy and control plant groups were clear. Sodium selenite significantly increased cataract grade (2.8 ± 0.2) when compared to the healthy group p = 0.001 . However, cataract grades were decreased considerably as 1.9 ± 0.72 and 1.5 ± 0.85 in groups that received 200 mg/kg and 400 mg/kg oral extract of A. officinalis, respectively. A. officinalis extract also restored all abnormalities of biochemical markers induced by sodium selenite. Conclusion. Our data suggest that A. officinalis could be a promising candidate as a safe alternative treatment in cataracts upon further clinical trials. This effect is probably associated with the antioxidant activity of A. officinalis.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite‐Induced Cataractogenesis in Experimental Animal Models

Azadbakht

Asghari

Dailami

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…In this case, a reduction of hydroperoxide's concentration, assessed by FOX-1 assays, and an increasing value of ferric reducing antioxidant power (FRAP) in both intra and extracellular fluid were observed. This is further confirmed by in vivo studies by Noroozpour et al, which showed that the hydroalcoholic petal extract of E. amoenum had a protective effect on selenite-induced cataracts in rats [51]. Likewise, Abbasi Larki et al [68] demonstrated that the petal of E. amoenum had a protective effect on permethrin-induced rat models.…”

Section: Oxidative Stressmentioning

confidence: 73%

“…Various alcoholic extracts of the petals of Echium have demonstrated different antioxidant activity levels [15,[49][50][51][52]. E. amoenum is one of the most studied species in the genus for antioxidant activity.…”

Section: Antioxidantsmentioning

confidence: 99%

Antioxidant Properties and Reported Ethnomedicinal Use of the Genus Echium (Boraginaceae)

et al. 2020

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The genus Echium L. from the Boraginaceae family consists of 67 recognised species. The genus is widely distributed in the Mediterranean, having been documented in the traditional medicine of the area since 300 B.C. Current pharmacological studies have validated early ethnomedicinal properties showing that Echium spp. possesses antioxidant, analgesic, anxiolytic, anti-inflammatory, antibacterial, and antiviral effects. Nevertheless, only limited papers report specifically on the phytochemistry of this genus. Furthermore, the potential of utilising extracts from Echium species as natural antioxidant preparations has been significantly neglected. For the first time, this review comprehensively describes and discusses the presence of recorded Echium species with ethnomedicinal uses, their antioxidative properties in vitro and in vivo when available, and major phytochemical components recognised as potent antioxidants, as well as the possibilities and opportunities for future research.

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“…Hydroalcoholic extract of Echium amoenum also elicited a protective effect against selenite-induced lens opacification in rats, in vivo. These investigators concluded that the antioxidant phytochemicals within the plant accounted for the anti-cataract activity of Echium amoenum [230].…”

Section: Plant-derived Compounds and Herbal Remediesmentioning

confidence: 99%

Current Trends in the Pharmacotherapy of Cataracts

et al. 2020

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Cataracts, one of the leading causes of preventable blindness worldwide, refers to lens degradation that is characterized by clouding, with consequent blurry vision. As life expectancies improve, the number of people affected with cataracts is predicted to increase worldwide, especially in low-income nations with limited access to surgery. Although cataract surgery is considered safe, it is associated with some complications such as retinal detachment, warranting a search for cheap, pharmacological alternatives to the management of this ocular disease. The lens is richly endowed with a complex system of non-enzymatic and enzymatic antioxidants which scavenge reactive oxygen species to preserve lens proteins. Depletion and/or failure in this primary antioxidant defense system contributes to the damage observed in lenticular molecules and their repair mechanisms, ultimately causing cataracts. Several attempts have been made to counteract experimentally induced cataract using in vitro, ex vivo, and in vivo techniques. The majority of the anti-cataract compounds tested, including plant extracts and naturally-occurring compounds, lies in their antioxidant and/or free radical scavenging and/or anti-inflammatory propensity. In addition to providing an overview of the pathophysiology of cataracts, this review focuses on the role of various categories of natural and synthetic compounds on experimentally-induced cataracts.

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Prevention of selenite-induced cataractogenesis by hydroalchoholic extract of Echium amoenum: An experimental evaluation of the Iranian traditional eye medication

Cited by 4 publications

References 20 publications

The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite‐Induced Cataractogenesis in Experimental Animal Models

The Preventive Effects of Asparagus officinalis Extract on Sodium Selenite‐Induced Cataractogenesis in Experimental Animal Models

Antioxidant Properties and Reported Ethnomedicinal Use of the Genus Echium (Boraginaceae)

Current Trends in the Pharmacotherapy of Cataracts

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