Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: The relevance of cannabinoid system

Matos, Israel; Bento, Allisson Freire; Marcon, Rodrigo; Claudino, Rafaela Franco; Calixto, João B.

doi:10.1016/j.molimm.2013.01.018

Cited by 52 publications

(39 citation statements)

References 49 publications

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“…These triterpenes have been reported to exert anti-inflammatory properties in various animal models, including colitis, cystitis or pancreatitis. [7][8][9] In the central nervous system, α-and β-amyrin have been reported to exhibit anti-nociceptive properties via the activation of cannabinoid receptors 10,11) and to exhibit antianxiety or anti-depression properties through the modulation of the benzodiazepine site of the γ-aminobutyric acid type A (GABA A ) receptor or noradrenergic receptor, respectively.…”

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confidence: 99%

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Park

Ahn

et al. 2014

Biological & Pharmaceutical Bulletin

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Alzheimer's disease, a neurodegenerative disorder, is characterized by progressive cognitive impairment associated with the disruption of cholinergic neurotransmission. The aim of the present study was to evaluate the effect of α-or β-amyrin, a type of pentacyclic triterpene, on the cognitive impairment induced by scopolamine, a muscarinic acetylcholine receptor antagonist. To measure the abilities of various types of learning and memory, we conducted step-through passive avoidance task. Scopolamine induced deficits in learning and memory processes in mice, which were antagonized by a single administration of α-amyrin (2 or 4 mg/kg) or β-amyrin (4 mg/kg), respectively. Additionally, in vitro analysis revealed that acetylcholinesterase activity was inhibited by β-amyrin, but not by α-amyrin. Furthermore, Western blot analysis revealed that the expression levels of phosphorylated extracellular signal-regulated kinase 1/2 (pERK) and phosphorylated glycogen synthase kinase-3β (pGSK-3β) were significantly enhanced by a single administration of α-and β-amyrin in the hippocampus. Finally, the memory ameliorating effects of α-or β-amyrin on the scopolamine-induced cognitive impairments were significantly blocked by ERK inhibitor U0126. The present study suggests that α-and β-amyrin may ameliorate the cognitive impairment induced by hypocholinergic neurotransmission via the activation of ERK as well as GSK-3β signaling.

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confidence: 99%

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Park

Ahn

et al. 2014

Biological & Pharmaceutical Bulletin

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“…CB1 antagonists can attenuate the anti-inflammatory activity of salvinorin A (Aviello et al, 2011) and α,β-amyrin (Matos et al, 2013), two natural products that exhibit activities in different models of inflammation. On the other hand, CB1 receptor agonists inhibit ear swelling in mice induced by capsaicin (Richardson et al, 1998).…”

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confidence: 99%

Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms

Godin

Araújo

César

et al. 2015

European Journal of Pharmacology

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“…However, long-term usage of these drugs may induce side effects, such as diarrhea, abdominal cramps, and even Cushing's syndrome. Therefore, natural product remedies are alternative strategies for treatment of IBD (31) and for prevention of outbreaks (32,33).…”

Section: Anti-inflammatory Properties Of Oat Extracts In Vivomentioning

confidence: 99%

Anti-inflammatory, counteractive, and preventive effects of orally administrated oat extracts on dextran sulfate sodium-induced colitis in mice

Hasnat

Pervin

Park

et al. 2015

Food Sci Biotechnol

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The anti-inflammatory effects of oat extracts in vitro and in vivo were determined based on antioxidant functions. To examine the effect of oat extracts in murine macrophage RAW 264.7 cells, MTT assays were used and nitric oxide (NO) production was analyzed based on absorbance and inducible nitric oxide synthase (iNOS) expression levels using Western blot analysis. Immunoglobulin expression levels were determined using an enzyme-linked immunosorbent assay (ELISA). Oat extracts showed significant (p<0.05) antioxidant properties and restored the cell viability of LPS-stimulated RAW 264.7 cells, compared with controls. NO production and iNOS protein levels were also reduced by oat extracts. DSS (3%)-administered mice manifested symptoms similar to human colitis patients, and oat extracts attenuated the symptoms of colitis. Preventive and therapeutic administration of oat extracts used as antioxidants can ameliorate inflammatory conditions in cells and DSS-induced colitis in mice.

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Preventive and therapeutic oral administration of the pentacyclic triterpene α,β-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: The relevance of cannabinoid system

Cited by 52 publications

References 49 publications

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Amyrin Attenuates Scopolamine-Induced Cognitive Impairment in Mice

Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms

Anti-inflammatory, counteractive, and preventive effects of orally administrated oat extracts on dextran sulfate sodium-induced colitis in mice

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