Preventive effect of daikenchuto, a traditional Japanese herbal medicine, on onset of ileus after gynecological surgery for malignant tumors

Oyama, Fumie; Futagami, Masayuki; Shigeto, Tatsuhiko; Miura, Rie; Osawa, Yuuki; Oishi, Masamichi; Oikiri, Hiroe; Yokoyama, Yoshihito; Takabayashi, Anna; Yokoyama, Yoshihiko

doi:10.1111/ajco.13329

Cited by 7 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…That would happen when Kampo medicine is widely accepted, like shakuyakukanzoto for painful muscle cramps [9] and similar pathophysiological conditions. Other commonly used Kampo formulas are rikkunshito for chemotherapy-induced anorexia [10], hangeshashinto for chemotherapy-induced oral mucositis [11], daikenchuto for postoperative ileus [12], goshajinkigan for peripheral neuropathy [13], and yokukansan for behavioral and psychological symptoms of dementia (BPSD) [14], although evidence for each formula is not yet strong enough.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Kampo case reports from the viewpoint of “Yasui Classification”

Motoo,

Yasui

2024

Traditional & Kampo Medicine

View full text Add to dashboard Cite

BackgroundThe “Yasui Classification” categorizes the indication for Kampo medicine into four main types in the medical field where standard treatment of Western medicine exists regardless of the school of Kampo medicine. We aimed to elucidate how Kampo case reports are presented from the viewpoint of the Yasui Classification.MethodsUsing the general presentations at the 69th Japan Society for Oriental Medicine (JSOM) Academic Meeting held in Osaka in June 2018, the contents of each abstract were analyzed with the Yasui Classification.ResultsThere were 289 abstracts. The numbers of included abstracts was 140 (48.4%), and their breakdown was as follows: Type 1: 97, Type 2: 27, Type 3: 12, and Type 4: 4. Therefore, Kampo monotherapy yielded the greatest number of presentations where Western medicine‐refractory cases were treated with Kampo medicine. In Type 2, which is the combination of Kampo and Western medicines, there were various applications of Kampo medicine in clinical fields such as pain control, respiratory, cardiovascular, and psychiatric subspecialties. Furthermore, in Type 3, which is also the combination of Kampo and Western medicines, 7 of 12 presentations were related to the alleviation of the side effects of cancer therapy.ConclusionsKampo monotherapy is most popularly reported at the Congress of JSOM in various fields of medicine, whereas the concurrent use of Kampo and Western medicines is also reported in a variety of clinical subspecialties. A new horizon of clinical significance for Kampo medicine will be opened with the Yasui Classification.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of Kampo case reports from the viewpoint of “Yasui Classification”

Motoo,

Yasui

2024

Traditional & Kampo Medicine

View full text Add to dashboard Cite

show abstract

“…In Japan, it has been widely used as a counterpart to Western medicine in a wide range of settings from family practices to advanced medical facilities. In recent years, many studies have focused on the efficacy and safety of DKT, especially in adults, and the targets of these studies have extended beyond the perioperative period to include functional constipation and gynecology 7–10 . The results of recent studies in the field of adult oncology are thoroughly summarized in a report by Aoyama and Tamagawa 7 .…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, many studies have focused on the efficacy and safety of DKT, especially in adults, and the targets of these studies have extended beyond the perioperative period to include functional constipation and gynecology. [7][8][9][10] The results of recent studies in the field of adult oncology are thoroughly summarized in a report by Aoyama and Tamagawa. 7 The authors conclude that although there are some promising clinical trials on the efficacy of DKT for perioperative and chemotherapy-related adverse events in adult cancer, the clinical efficacy is still limited and further trials are needed to investigate the clinical benefit.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of daikenchuto after laparoscopic surgery for perforated appendicitis

Higashio

Sato

Endo

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

Background: Although many recent studies have scientifically verified the efficacy of the traditional herbal medicine daikenchuto (DKT) for postoperative gastrointestinal function, its efficacy has not been established in children. We retrospectively evaluated the effect of DKT in pediatric patients with panperitonitis associated with perforated appendicitis (PaPA) who underwent laparoscopic appendectomy.Methods: Among 34 children with PaPA who underwent laparoscopic appendectomy from May 2012 to May 2021, 19 received DKT (group D) and 12 did not (group C). We compared postoperative gastrointestinal function, complications, and improvement in the inflammatory response between the two groups.Results: Of the evaluation parameters for postoperative gastrointestinal function, the mean ± standard deviation time to first flatus was significantly shorter in group D than in group C (1.21 ± 0.42 and 2.17 ± 0.94 days respectively; p = 0.0005). The time to ingestion of half a meal was also significantly shorter in group D than in group C (8.42 ± 3.69 and 12.50 ± 4.96 meal occasions respectively; p = 0.01). There was no significant difference in complication rates between the two groups.Conclusion: Daikenchuto rapidly and safely improved postoperative gastrointestinal symptoms in children with PaPA. To the best of our knowledge, this is the first study to evaluate the effect of DKT on postoperative symptoms in laparoscopic appendectomy and in children.

show abstract

“…POI was frequently observed after gastroenterological surgery, and it was followed by gynecological surgery [ 3 ]. It was reported that the prevalence of POI ranged from 5% to 25% among patients undergoing gynecological surgery [ 4 ], and even the incidence was up to 50% in patients receiving surgical therapy for gynecological cancers [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture for Gastrointestinal Function Recovery after Gynecological Surgery: A Systematic Review and Meta-Analysis

Gao

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Evidence for the efficacy and safety of electroacupuncture (EA) on gastrointestinal function recovery after gynecological surgery is unclear. Objective. This meta-analysis aimed to evaluate the effects of EA on recovery of postoperative gastrointestinal function for patients receiving gynecological surgery. Data sources: PubMed, Cochrane Central Register of Controlled Trials (CINAHL), Embase, China National Knowledge Infrastructure (CNKI), Weipu (CQVIP), and Wanfang databases were systematically searched from the inception dates to May 30, 2020, for relevant randomized controlled trials (RCTs). Study selection: RCTs that evaluated EA for postoperative gastrointestinal function directly related to gynecological surgery in adults aged 18 years or over. Data extraction and synthesis: paired reviewer independently extracted the data and assessed study quality. Standardized mean differences (SMD) were calculated as the effect measure from a random effects model. Main outcomes and measures: time to first flatus (TFF), time to bowel sounds recovery (TBS), and time to first defecation (TFD) were recorded as primary outcomes; postoperative nausea and vomiting (PONV), motilin (MTL), gastrin (GAS), pH value of gastric mucosa (pHi), gastric mucosal partial pressure of carbon dioxide (PgCO2), vasoactive intestinal peptide (VIP), and adverse event were reported as secondary outcomes. Results. We included eighteen RCTs (1117 participants). Our findings suggested that compared to the control group (CG), electroacupuncture group (EG) showed significant effects on TFF (SMD = −0.98, 95% CI: [−1.28, −0.68], P < 0.00001 , I2 = 69%), TBS (SMD = −0.98, 95% CI: [−1.84, −0.12], P = 0.03 , I2 = 92%), and TFD (SMD = −1.23, 95% CI: [−1.59, −0.88], P < 0.0001 , I2 = 0%). Moreover, the incidence of PONV at postoperative 6 h (OR = 0.42, 95% CI: [0.27, 0.64], P < 0.0001 , I2 = 0%) and 24 h (OR = 0.46, 95% CI: [0.32, 0.68], P < 0.0001 , I2 = 0%) was lower in the EG than that in the CG, whereas no significant difference in ratio of PONV at postoperative 48 h (OR = 0.55, 95% CI: [0.20, 1.51], P = 0.25 , I2 = 0%) was detected between the two groups. Meanwhile, there was a significant effect in favor of EA on the level of MTL at postoperative 6 h (SMD = −0.93, 95% CI: [−1.36, −0.61], P < 0.0001 , I2 = 21%), while no significant effect was observed at postoperative 24 h (SMD = −0.43, 95% CI: [−0.89, 0.02], P = 0.06 , I2 = 69%) in the EG when compared to the CG. Additionally, a large significant effect on decreasing PgCO2 was found in the EG in comparison to the CG, but no significant effect in favor of EA on GAS, VIP, or pHi was observed. It was reported that there was one participant with pain at the needling sites and bruising, and three participants withdrew because they were not intolerant to EA. Conclusions. EA could be a promising strategy for the prevention and treatment of gastrointestinal dysfunction after gynecological surgery, including shortening TFF and TFD, TBS, regulating MTL, and decreasing the ratio of PONV within postoperative 24h. The effects on MTL and PONV varied with different intervention points, and EA used at 30 min prior to surgery might be recommended. However, the evidence quality ranged from low to very low, and large-scale and high-quality RCTs were warranted.

show abstract

Preventive effect of daikenchuto, a traditional Japanese herbal medicine, on onset of ileus after gynecological surgery for malignant tumors

Cited by 7 publications

References 20 publications

Analysis of Kampo case reports from the viewpoint of “Yasui Classification”

Analysis of Kampo case reports from the viewpoint of “Yasui Classification”

Efficacy of daikenchuto after laparoscopic surgery for perforated appendicitis

Electroacupuncture for Gastrointestinal Function Recovery after Gynecological Surgery: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About