Preventive effects of Dendrobium candidum Wall ex Lindl. on the formation of lung metastases in BALB/c mice injected with 26-M3.1 colon carcinoma cells

Abstract

Dendrobium candidum Wall ex Lindl. (D. candidum) is a traditional Chinese medicine widely used in Asia. The present study has showed that D. candidum exerted an anti-metastatic effect in mice injected with 26-M3.1 colon carcinoma cells. D. candidum showed the most marked tumor inhibitory rate of 64.5% at a dose of 400 mg/kg body weight (b.w). The mRNA and protein expression of Bax in lung tissue of D. candidum-treated mice was shown to be higher as compared with control mice, whereas the mRNA and protein expression of Bcl-2 showed the opposite trend. Decreased mRNA and protein expression of MMP and increased expression of TIMPs was demonstrated in lung tissues by quantitative polymerase chain reaction and western blot assays. D. candidum reduced the serum cytokine levels of IL-6, IL-12, TNF-α and IFN-γ to a greater extent as compared with the control mice, and administration of 400 mg/kg b.w. resulted in a lower serum cytokine levels as compared with mice treated with 200 mg/kg b.w. Eleven compounds were in the D. candidum leaf, of which the functional contents may help to generate novel treatments for the prevention of lung metastases. The results of the present study have demonstrated that D. candidum had a potent in vivo antitumor and anti-metastatic effect in BALB/c mice injected with 26-M3.1 cells.

Dendrobium officinale Orchid Extract Prevents Ovariectomy-Induced Osteoporosis in Vivo and Inhibits RANKL-Induced Osteoclast Differentiation in Vitro

“…The orchid D. officinale possesses unique medicinal properties, and has been widely utilized in Asian traditional medicine for the prevention and treatment of various ailments, including obesity, diabetes, hypertension, hyperlipidemia, inflammation, and cancer ( Li L. et al, 2011 ; Li G. et al, 2014 ; Wang Q. et al, 2014 ). A close relative, D. moniliforme , another medicinal orchid, has also recently been reported to exert inhibitory effects on both in vitro RANKL-induced osteoclast differentiation and in vivo lipopolysaccharide-induced bone erosion ( Baek et al, 2016 ).…”

Dendrobium Officinale Polysaccharides Protect against MNNG-Induced PLGC in Rats via Activating the NRF2 and Antioxidant Enzymes HO-1 and NQO-1

“…officinale Kimura et Migo (D. officinale) ( Tiepi Shihu in Chinese) belongs to genus Dendrobium [12] and displays anticancer effects on MCF cells, HCT-116 cancer cells, and HepG2 liver cancer cells in vitro [13–15]. Researchers also discovered that D. officinale exhibited preventive effects on the formation of lung metastases and colon carcinogenesis in mice [16, 17]. Our research group has found that D. officinale extraction (DOE) can prevent gastric carcinogenesis in rats through upregulating Bax and downregulating such factors as antiapoptotic B cell lymphoma 2 (Bcl-2), epidermal growth factor (EGF), epidermal growth factor receptor (EGFR), and sphingosine-1-phosphate (S1P) [18, 19].…”

Protective effects of Dendrobium candidum Wall ex Lindl. on high‐fat diet‐induced liver damage in mice

“…Dendrobium candidum has long been used as a traditional Chinese herb drug (Wang et al, 2014). It has a broad range of biological functions, including anticancer activity (Li, Sun, Zhou, et al, 2014), osteoprotection (Wang et al, 2018), and inflammatory regulation effects (Gong et al, 2020). Recent studies also reveal the hepatic therapeutic effect of D. candidum (Li, Sun, Wang, et al, 2014).…”