Previous Dengue Infection and Mortality in Coronavirus Disease 2019 (COVID-19)

Silvestre, Odílson Marcos; Costa, Lílian Lúcia; Lopes, Bianca V R; Barbosa, Mariana Ramos; Botelho, Kárenn Klycia Pereira; Albuquerque, Kelvyn L C; Souza, Anna G S; Coelho, Lorran A; Oliveira, Anderson José de; Barantini, Cínthia B; Neves, Sebastião Afonso Viana Macedo; Nadruz, Wilson; Maguire, James H.; Fernandes-Silva, Miguel Morita

doi:10.1093/cid/ciaa1895

Cited by 34 publications

(36 citation statements)

References 10 publications

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“…No matter how worse the COVID-19 pandemic, countries should pay attention to the prevention and control of dengue, especially in low-income countries where dengue fever is prevalent. Considering that COVID-19 and dengue might share the similar clinical manifestations that affect the medical control and diagnosis (31,(44)(45)(46) and the overlap outbreak will lead to competition for medical resources (47)(48)(49)(50), countries should formulate strategies for their own situation and strictly control the dengue epidemic. The data collection of this study is limited.…”

Section: Discussionmentioning

confidence: 99%

The Potential Influence Factors To Dengue Epidemic Changes In Different Countries During COVID-19 Pandemic

Fan

Kang

Wang

et al. 2021

Preprint

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Background During the swooped coronavirus pandemic in 2020, the non-pharmaceutical interventions (NPIs) not only controlled the pandemic of coronavirus, but also had impacts on other infectious diseases. Dengue has become a disease that calls for key detection with it spreading rapidly worldwide in recent years. This study aims to discuss the impacts of the potential influence factors on dengue during the coronavirus according to the data of dengue pandemic of different countries around the world. Methods We collected the data of 2019 and 2020 dengue cases from 57 countries around the globe. Through correlation analysis and rank sum analysis, we sought to discuss the potential effects of different factors during the outbreak of COVID-19 on dengue. Results The results showed that dengue case subtractions had a significant correlation with the territorial area, the suffered and the deceased number of COVID-19 cases. Further rank sum analysis indicated that there is a significant difference in the number of dengue fever cases between the two years, countries with different continental locations, 2019 and 2020 GDPs per capita, the gaps between two years, territory areas, populations and coronavirus occurrences. Conclusions The results altogether showed that the coronavirus pandemic affected dengue epidemic on a certain degree. Considering the epidemic of dengue is closely related to national economy, geography and demography, our results also further indicated that individual measures should be taken to suppress the development of dengue in different countries depending on their own circumstances, especially during major health events.

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Section: Discussionmentioning

confidence: 99%

The Potential Influence Factors To Dengue Epidemic Changes In Different Countries During COVID-19 Pandemic

Fan

Kang

Wang

et al. 2021

Preprint

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“…Patients without previous dengue had a higher risk of death (hazard ratio: 0.44; 95% confidence interval: 0.22 to 0.89; p = 0.023) at the 60-day followup. These findings have raised the possibility that dengue may induce immunological protection against SARS-CoV-2 [161].…”

Section: Coronavirus Disease 2019 (Covid-19)mentioning

confidence: 99%

Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases

et al. 2021

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Circulating full-length osteopontin (FL-OPN) is elevated in plasma from patients with various infectious diseases, such as adult T-cell leukemia, Mycobacterium tuberculosis (TB), hepatitis virus infection, leptospirosis, acquired immune deficiency syndrome (AIDS), AIDS/TB, and coronavirus disease 2019 (COVID-19). Proteolysis of OPN by thrombin, matrix metalloproteases, caspase 8/3, cathepsin D, plasmin, and enterokinase generates various cleaved OPNs with a variety of bioactivities by binding to different target cells. Moreover, OPN is susceptible to gradual proteolysis. During inflammation, one of the cleaved fragments, N-terminal thrombin-cleaved OPN (trOPN or OPN-Arg168 [OPN-R]), induces dendritic cell (DC) adhesion. Further cleavage by carboxypeptidase B2 or carboxypeptidase N removes Arg168 from OPN-R to OPN-Leu167 (OPN-L). Consequently, OPN-L decreases DC adhesion. In particular, the differences in plasma level over time are observed between FL-OPN and its cleaved OPNs during inflammation. We found that the undefined OPN levels (mixture of FL-OPN and cleaved OPN) were elevated in plasma and reflected the pathology of TB and COVID-19 rather than FL-OPN. These infections are associated with elevated levels of various proteases. Inhibition of the cleavage or the activities of cleaved products may improve the outcome of the therapy. Research on the metabolism of OPN is expected to create new therapies against infectious diseases.

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“…The study observed decreased mortality among covid patients who had previously experienced symptomatic dengue infection (hazard ratio: .44; 95%, confidence interval: .22-.89; P = .023) in a 60-day record. It is suggested the possibility that dengue might encourage immunological safety against severe SARS-CoV-2 virus infection [37] . Nicolelis et al Observed an inverse relationship between Covid-19 and dengue cases in the regions around Asia, islands in the pacific, Latin America, and Indian oceans.…”

Section: Covid-19 Patients With Previous Dengue Infectionmentioning

confidence: 99%

Symptomatic similarity, co-infection and cross-reactivity in dengue and Covid-19 disease

Garg¹,

Meena²

2021

Int. J. Mosq. Res.

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The Corona pandemic, brought about by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is pronounced international public health crisis with shocking health impacts. The Covid-19 disease has created the symptoms misdiagnosis complicacy in tropical and subtropical areas of the world, that are dengue endemic regions too to the population. The dengue is cause by dengue virus (DENV). Initially, there is similarity in the sign and symptoms of patients with Covid-19 and dengue, namely fever, headache, myalgia associated with thrombocytopenia, leukopenia, and abnormal liver function tests. The similarity in clinical symptoms in Covid-19 and dengue fever has to raise the issue of co-infection and symptoms misleading. In addition, co-infection followed by cross-reactivity between antibodies against DENV and SARS-CoV-2 serology tests has been recorded in reports. Furthermore, cross-reactivity of the immune reaction in these infections is an emerging issue, Covid-19 through counteracting agent subordinate upgrade as pre-existing DENV-antibodies may possibly influence Covid-19 through antibody-dependent enhancement. Some studies have proposed that Covid-19 disease and transmission might be slower in dengue-endemic locales of the world. This review deals with the concern of misdiagnosis challenges due to Covid-19 and dengue fever, co-infection, cross-reactivity between SARS-CoV-2 and DENV antibodies. Simultaneous pandemics of dengue and Covid-19, just as the chance of co-contamination, add to the generally significant burden on healthcare services.

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Previous Dengue Infection and Mortality in Coronavirus Disease 2019 (COVID-19)

Cited by 34 publications

References 10 publications

The Potential Influence Factors To Dengue Epidemic Changes In Different Countries During COVID-19 Pandemic

The Potential Influence Factors To Dengue Epidemic Changes In Different Countries During COVID-19 Pandemic

Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases

Symptomatic similarity, co-infection and cross-reactivity in dengue and Covid-19 disease

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