Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of literature

Nuwal, Paras; Dixit, Ramakant; Singhal, A. K.

doi:10.4103/0970-2113.68330

Cited by 24 publications

(17 citation statements)

References 11 publications

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“…Misdiagnosis of TC as thyroid tumour was also described by other authors. 9, 21 In their report, Licht et al . described 109 cases of TC among which 17 were diagnosed incidentally at autopsy and 21% of treated patients received asthma medication due to symptoms present at the time of diagnosis.…”

Section: Discussionmentioning

confidence: 94%

Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

Napieralska

Miszczyk

Blamek

2016

Radiology and Oncology

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BackgroundTracheal cancers (TC) are rare and treatment results that are reported are typically not satisfactory. The purpose of this research was assessment of the results of treatment of TC patients, identification of potential additional surgery candidates, evaluation of prognostic factors, and assessment of the occurrence of other malignancies.Patients and methodsThe Regional Cancer Database and the Hospital Database were searched for patients with tracheal neoplasms. Fifty-eight of 418 patients identified initially, met the inclusion criteria (primary TC with confirmed histology and complete treatment records). Standard statistical tests were used.ResultsSquamous cell carcinoma (SCC; 63.8%) and adenoid cystic carcinoma (ACC; 15.5%) were the most commonly diagnosed histological types of TC. Radiotherapy was delivered in 48 cases, surgery or endoscopic resection in 20, and chemotherapy in 14. TC was diagnosed as a second cancer in 10 patients, in 1 patient it occurred prior to the lung cancer, and in 1 was diagnosed simultaneously. During the median follow-up of 12.7 months, 85.5% of the patients died because of the disease. Local recurrence occurred in 17% cases. In univariate analysis, patients with ACC had statistically better five-year overall survival (77.8%) than those diagnosed with SCC (8.4%, p = 0.0001). Radiotherapy, performance status and haemoptysis were factors significantly influencing overall survival (OS) in the multivariate analysis. Among patients who were not treated surgically, 15–26% were found to constitute additional surgery candidates, depending on the selection criteria.ConclusionsThe diagnostic workup should be focused on the identification of TC patients suitable for invasive treatment and radiotherapy. Respiratory system cancer survivors can be considered a risk group for tracheal cancer. Radiotherapy constitutes an important part of the treatment of patients with TC.

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Section: Discussionmentioning

confidence: 94%

Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

Napieralska

Miszczyk

Blamek

2016

Radiology and Oncology

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“…Cytologically, ACC is characterized by monomorphic basaloid small round or oval tumor cells with round nuclei, small indistinct nucleoli, scant cytoplasm, and no inclusions, ranging in strands or clumps surrounding globules of acellular, homogenous spaces filled with mucoid or hyaline material (17). Three pathological patterns of ACC have been well-described, namely the cribriform, trabecular and solid types, with the cribriform type being the most prevalent.…”

Section: Discussionmentioning

confidence: 99%

Primary Adenoid Cystic Carcinoma of the Upper Anterior Mediastinum Mimicking a Thyroid Tumor: A Case Report and Review of Literature

Sun

et al. 2020

Front. Endocrinol.

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Primary adenoid cystic carcinoma (ACC) of the upper anterior mediastinum mimicking a thyroid tumor has rarely been seen in clinical practice and lacks a standard of care therapy. Here, we report a 47-year old female patient with an ACC originated from the upper anterior mediastinum presenting as a thyroid gland tumor. The patient received gross surgical resection of the tumor and underwent post-surgical chemotherapy and radiotherapy. The patient was free from local recurrence 3-years following initial treatment, but developed multiple lung metastases. She remains under clinical observation without discomfort and is still followed as an outpatient. Here, we also summarized recent reports of similar cases with hope to provide some experience for future clinical practice.

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“…CT is a useful imaging procedure for tracheal tumors [13]. The conventional CT scan of the chest and trachea is recommended for this kind of tumor, and endoscopic examination is the best way to evaluate obstruction.…”

Section: Discussionmentioning

confidence: 99%

Surgical Management of Malignant Tumors of the Trachea: Report of Two Cases and Review of Literature

et al. 2012

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Malignant neoplasms occurring from the trachea are extremely rare. Therefore, their clinical characteristics and surgical results have not been thoroughly discussed. These tumors are often misdiagnosed and treated as bronchial asthma or chronic obstructive pulmonary disease. It is critically important to probe the cause-effect relationship between the medical presentations and the clinical diagnosis. In this report, two cases of tracheal malignancy suffering from dyspnea due to obstruction of the proximal trachea are described, and a review of the literature is presented.

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Primary adenoid cystic carcinoma of trachea presenting as midline neck swelling and mimicking thyroid tumor: A case report and review of literature

Cited by 24 publications

References 11 publications

Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

Tracheal cancer – treatment results, prognostic factors and incidence of other neoplasms

Primary Adenoid Cystic Carcinoma of the Upper Anterior Mediastinum Mimicking a Thyroid Tumor: A Case Report and Review of Literature

Surgical Management of Malignant Tumors of the Trachea: Report of Two Cases and Review of Literature

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