Primary amyloidosis of urinary bladder: Mimicking transitional cell carcinoma bladder?

Karan, S.C.; Shah, Amit Kumar; Srivastava, Anand; Bhardwaj, R. K.

doi:10.1016/j.mjafi.2014.11.004

Cited by 7 publications

(14 citation statements)

References 9 publications

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“…Both sexes are equally affected, most commonly during the fifth and seventh decades of life (4). The most frequent symptom of amyloidosis in the bladder is gross haematuria (7).…”

Section: Discussionmentioning

confidence: 99%

“…Localized deposition of amyloid may occur in any organ in the absence of systemic involvement (12). Primary localized amyloidosis of the urinary bladder is uncommon, however, the bladder is the most common site of involvement (3,4). Primary amyloidosis is also the most common form of localized amyloidosis in the bladder (11).…”

Section: Cystoscopic Examination Of Bladder Amyloidosis Often Shows Ymentioning

confidence: 99%

“…The lesion can easily mimic malignancy because of its appearance on radiological examination and cystoscopy (3,4,5). Histopathological evaluation is necessary to exclude malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Primary Localized Amyloidosis of the Bladder Mimicking Neoplasia

Ekmekçi¹,

Küçük²,

Çakır³

et al. 2018

jus

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A 63-year-old woman was admitted to our hospital with macroscopic hematuria in 2013. On computed tomography, the bladder wall thickness was 2 cm, suspicious for malignancy. Cystoscopy showed irregularity in the posterolateral side of the bladder. Transurethral resection was performed. Histopathological examination revealed a dense homogeneous eosinophilic material in the lamina propria which showed positive orange-red staining with apple-green birefringence under polarized light. There were no signs of systemic amyloidosis at the time of diagnosis and during the 36 months of follow-up. Differential diagnosis of amyloidosis in the bladder includes urothelial carcinoma due to its appearance on imaging and cystoscopy. Histopathological evaluation is a requirement for accurate diagnosis. Keywords: Primary, Amyloidosis, Bladder Altmış üç yaşında kadın hasta 2013 yılında makroskopik hematüri ile hastanemize başvurdu. Bilgisayarlı tomografide, mesane duvarının posterolateral ve superior kısmının, tümör açısından şüphe uyandıracak şekilde 2 cm kalınlığında olduğu görüldü. Sistoskopik bakıda mesanenin posterolateral tarafında düzensiz alanlar görüldü. Transüretral mesane rezeksiyonu ile kürete materyal elde edildi. Biyopside lamina propriada turuncu-kırmızı boyanma gösteren, yoğun, homojen eozinofilik materyal izlendi ve polarizasyonda elma yeşili çift kırılımı gösterildi. Olguda tanı anında ve 36 aylık takiplerinde sistemik amiloidoz bulguları saptanmadı. Mesanenin amiloidozu, görüntüleme yöntemlerinde ve sistoskopide ürotelyal karsinom ile kolayca karışabilen nadir bir durumdur. Kesin tanı için histopatolojik inceleme şarttır.

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“…Both sexes are equally affected, most commonly during the fifth and seventh decades of life (4). The most frequent symptom of amyloidosis in the bladder is gross haematuria (7).…”

Section: Discussionmentioning

confidence: 99%

Section: Cystoscopic Examination Of Bladder Amyloidosis Often Shows Ymentioning

confidence: 99%

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Primary Localized Amyloidosis of the Bladder Mimicking Neoplasia

Ekmekçi¹,

Küçük²,

Çakır³

et al. 2018

jus

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“…Mesanenin primer lokalize amiloidozu etiyolojisi net olarak bilinmeyen bir hastalıktır. İlk kez 1853 yılında Virchow tarafından tanımlanmıştır (3). Mesanenin primer amiloidozu çok nadir olmakla birlikte, üriner organlarda sekonder amiloid birikiminde özellikle böbrek tutulumu izlenir (4).…”

Section: Introductionunclassified

“…Mesanenin primer amiloidozu çok nadir olmakla birlikte, üriner organlarda sekonder amiloid birikiminde özellikle böbrek tutulumu izlenir (4). Mesanede lokalize amiloidoz klinik prezentasyonu, sistoskopik görüntüsü ve radyolojik tetkiklerle mesane tümörünü taklit eder (3). Histopatolojik inceleme altın standart tanı yöntemi olup, alınan doku örneklerin Kongo kırmızısı boyama yönteminde röfle vermesi tipiktir (5).…”

Section: Introductionunclassified

Primary Amyloidosis of Bladder: A Rare Cause of Macroscopic Hematuria

Sökmen¹,

Şeker²,

Arikan³

et al. 2018

BTDMJB

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Primary amyloidosis of the bladder is very rare and its etiology is not known. Although gros hematuria and irritative voiding symptoms are seen clinically, the most important one is hematuria. Bladder localized amyloidosis mimics the bladder tumor with its clinical presentation, cystoscopic appearance, and radiological examinations. The definitive diagnosis method is histopathological examination and it is typical for the tissue samples to give Congo red stain apple-green birefringence under polarized light. The gold standard treatment for primary amyloidosis is transurethral resection. As a result, the only treatment of amyloid accumulation in the bladder-like bladder with symptoms whose symptoms resemble tumoral resection is the presence of malignancies, and the patient should be followed up closely after resection.

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