Primary and Secondary Dermatologic Disorders of the Breast

Carr, Ryan J.; Smith, Stephen M.; Peters, Sara

doi:10.1016/b978-0-323-35955-9.00013-1

Cited by 2 publications

(1 citation statement)

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“…Redness (erythema) and heat (calor) are typical symptoms of inflammation due to the increased perfusion [19]. In fact, with breast cancer specifically, inflammatory breast cancer is a phenotype characterized by gross inflammation that typically presents with palpable warmth as a symptom [20][21][22][23][24]. Although the inflammatory response is designed to repair or heal tissue, immune inflammatory cells counterintuitively have tumor-promoting characteristics that enhance angiogenesis and cellular proliferation [5].…”

Section: Introductionmentioning

confidence: 99%

Pilot Clinical Study Investigating the Thermal Physiology of Breast Cancer via High-Resolution Infrared Imaging

et al. 2021

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This descriptive study investigates breast thermal characteristics in females histologically diagnosed with unilateral breast cancer and in their contralateral normal breasts. The multi-institutional clinical pilot study was reviewed and approved by the Institutional Review Boards (IRBs) at participating institutions. Eleven female subjects with radiologic breast abnormalities were enrolled in the study between June 2019 and September 2019 after informed consent was obtained. Static infrared images were recorded for each subject. The Wilcoxon signed rank test was used to conduct paired comparisons in temperature data between breasts among the eight histologically diagnosed breast cancer subjects (n = 8). Localized temperatures of cancerous breast lesions were significantly warmer than corresponding regions in contralateral breasts (34.0 ± 0.9 °C vs. 33.2 ± 0.5 °C, p = 0.0142, 95% CI 0.25–1.5 °C). Generalized temperatures over cancerous breasts, in contrast, were not significantly warmer than corresponding regions in contralateral breasts (33.9 ± 0.8 °C vs. 33.4 ± 0.4 °C, p = 0.0625, 95% CI −0.05–1.45 °C). Among the breast cancers enrolled, breast cancers elevated temperatures locally at the site of the lesion (localized hyperthermia), but not over the entire breast (generalized hyperthermia).

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