Primary Canine and Feline Nervous System Tumors: Intraoperative Diagnosis Using the Smear Technique

Vernau, Karen M.; Higgins, Robert; Bollen, Andrew W.; Jiménez, Daniel Fernando López; Anderson, J. V.; Koblik, Philip D.; Lecouteur, Richard A

doi:10.1354/vp.38-1-47

Cited by 76 publications

(89 citation statements)

References 16 publications

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“…48 Immunocytochemical analysis performed on impression smears of meningiomas, in which the variant was not reported, also demonstrated cytokeratin staining in focal cell clusters. 49 Thus, our data indicate that many cells in canine meningiomas will express cytokeratins in addition to vimentin.…”

Section: Discussionmentioning

confidence: 56%

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Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Barnhart

Wojcieszyn²,

Storts

2002

Vet Pathol

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Abstract. This study examined immunohistochemical staining patterns for several meningioma variants involving either the brain or spinal cord of dogs. Formalin-fixed, paraffin-embedded tissue from 15 tumors was obtained. The selected tumor group included seven meningothelial, three transitional, two malignant (anaplastic), one myxoid, one papillary, and one osteomatous meningiomas. Tumors were evaluated for reactivity to the following six immunohistochemical markers: vimentin, pancytokeratin, glial fibrillary acidic protein (GFAP), S100, neuron-specific enolase (NSE), and synaptophysin. Vimentin expression was detected in all meningiomas, and 14 of 15 tumors demonstrated intense vimentin staining in more than 50% of the neoplastic cells. Pancytokeratin expression was present in 11 of 15 neoplasms; however, positive staining frequently was focal and often involved a small percentage of the neoplastic cells. GFAP expression was detected in a single, anaplastic meningioma. Although expression of NSE and S100 was detected in 12 of 25 meningiomas, the intensity of the staining and the percentage of positive neoplastic cells was highly variable. Synaptophysin was uniformly negative. These results will help to establish immunohistochemical profiles for meningiomas that will improve our ability to correctly differentiate these neoplasms of meningeal origin from central nervous system tumors originating from other sites.

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Section: Discussionmentioning

confidence: 56%

“…48,49 In the human literature, numerous studies have characterized the degree of epithelial differentiation in meningiomas by use of several markers, primarily cytokeratins and EMA. Human studies have consistently reported a high level of EMA expression.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Barnhart

Wojcieszyn²,

Storts

2002

Vet Pathol

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“…Histiocytic sarcoma (HS) in cats has been reported to date in the intestinal wall, femur, tarsus, spleen and liver, and mediastinal and vertebral canals [1,5,11,13,16]. A brief description of an HS in the central nervous system (CNS) of a cat was reported only in a review article [19], while malignant histiocytic disorders have been well demonstrated in the canine CNS [2,4,14,18,20]. This report documents the features of a brain tumor in a cat.…”

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confidence: 73%

Histiocytic Sarcoma in the Brain of a Cat

Uchida

Tamura³

et al. 2010

J. Vet. Med. Sci.

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ABSTRACT. A mass lesion in the subependymal region of the lateral ventricle in a 13-year-old neutered male mongrel cat with a complaint of somnolence, right circling movement and posture abnormality was examined. The magnetic resonance image examination revealed a relatively large T1-hypointense and T2-hyperintense mass lesion in the left interventricular foramen region, and there were no abnormalities in the chest and abdominal x-ray radiographic, funduscopic, and electric retinogram findings. The cat was died 43 days after the initial referral, and the post-mortem examinations revealed a poorly demarcated subependymal mass. Histologically, the brain lesion consisted of complex proliferation of highly pleomorphic cells resembling histiocytes with atypia and abundant mitotic figures. Moderate infiltrates of small reactive lymphocytes were admixed with the pleomorphic cell population. Gemistcytic astrocytes were also intermingled with the periphery of neoplastic foci. Immunohistochemically, most of the pleomorphic cells were positive for HLA-DR alphachain and ionized calcium binding adaptor molecule 1, and few were positive for lysozyme and alpha-1 antichymotrypsin. The atypical pleomorphic cells were negative for CD3, IgG (H and L), glial fibrillary acidic protein and neurofilament, suggesting monocytic/histiocytic-origin of the cells. The number of Ki-67-positive cell nuclei was extremely large, reflecting the high growth activity of these cells. Based on the findings, the lesion was considered as histiocytic sarcoma.KEY WORDS: brain, feline, histiocytic sarcoma, immunohistochemistry.J. Vet. Med. Sci. 72(1): 99-102, 2010 In dogs, histiocytic disorders have been classified into 3 major categories: canine cutaneous histiocytoma; canine reactive histiocytoses (both cutaneous and systemic); and histiocytic sarcoma complex (both localized and disseminated histiocytic sarcoma) [10]. Cats, in contrast, are rarely affected by these diseases [6]. Histiocytic sarcoma (HS) in cats has been reported to date in the intestinal wall, femur, tarsus, spleen and liver, and mediastinal and vertebral canals [1,5,11,13,16]. A brief description of an HS in the central nervous system (CNS) of a cat was reported only in a review article [19], while malignant histiocytic disorders have been well demonstrated in the canine CNS [2,4,14,18,20]. This report documents the features of a brain tumor in a cat. The histological and immunohistochemical natures characterized by the proliferation of highly pleomorphic cells resembling histiocytes and immunoreactivity for HLA-DR and ionized calcium binding adaptor molecule 1 (Iba1) are consistent with HS [7,8,15].A 13-year-old neutered male mongrel cat was presented to a private animal hospital with a complaint of somnolence, blindness, right circling movement and posture abnormality. The neurological examinations revealed a postural reaction decrease, a left mydriasis and disappearance of a physiologic nystagmus. Complete blood cell count and serum biochemical analyses were within normal ranges...

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“…Além dessas vantagens, não há necessidade de sedar o animal e permite que se realizem múltiplas coletas e amostragens em série, particularmente necessárias quando se observam resultados inconclusivos ou quando existe suspeita de recidiva da neoplasia 21 . Essa versatilidade da citologia aspirativa somada à rapidez com que as colorações podem ser realizadas proporcionam aos clínicos diagnóstico rápido, seguro e definitivo na grande maioria das situações 20,29 .…”

Section: Discussionunclassified

“…As vantagens deste método estão relacionadas à rapidez do diagnóstico, ao baixo custo e à sua eficácia. Além disso, causa desconforto mínimo ao paciente, permitindo que se realizem múltiplas colheitas e amostragens em série, particularmente interessantes quando surgem resultados inconclusivos ou quando existe suspeita de recidiva da lesão 21 . No homem e no cão cada vez mais há estudos que empregam a PAAF para o diagnóstico deste tipo de neoplasia 4,22,23,24,25 .…”

Section: Introductionunclassified

Classificação citológica dos linfomas caninos

Suzano

Sequeira

Rocha

et al. 2010

Braz. J. Vet. Res. Anim. Sci.

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ResumoOs linfomas estão entre as neoplasias mais frequentes na espécie canina. Do IntroduçãoOs linfomas estão entre as neoplasias mais frequentes na espécie canina 1,2,3,4,5 . Nesta espécie, sua incidência é de seis a trinta casos em cada 100.000 cães/ano, sendo maior que na espécie humana 6,7,8 . Ocorrem mais frequentemente em animais com idade entre 5 e 11 anos 9,10,11 , não havendo predileção por sexo 5,11 . Na espécie canina, esta neoplasia é considerada multifatorial e ainda não foi confirmada a participação de agentes virais ou químicos no seu aparecimento 3,12,13 .Os linfomas não-Hodgkin (LNH) do homem apresentam várias características em comum com os linfomas dos cães, particularmente com relação à epidemiologia, etiologia, clínica, morfologia e fenotipagem. Graças a essas semelhanças, os esquemas para classificação morfológica propostas para os LNH -como as de Kiel e Working Formulation -são utilizadas com sucesso por diversos autores para diagnosticar os linfomas da espécie canina. De acordo com alguns autores as características morfológicas dos LNH do homem servem como base para o estabelecimento do prognóstico e de

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Primary Canine and Feline Nervous System Tumors: Intraoperative Diagnosis Using the Smear Technique

Cited by 76 publications

References 16 publications

Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Histiocytic Sarcoma in the Brain of a Cat

Classificação citológica dos linfomas caninos

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