Primary choriocarcinoma of the lung

Tanimura, Akira; Natsuyama, Hideyasu; Kawano, Michifumi; Tanimura, Yoko; Tanaka, Tatsuo; Kitazono, Masatomo

doi:10.1016/s0046-8177(85)80045-9

Cited by 50 publications

(35 citation statements)

References 7 publications

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“…The tumors could also represent metastatic lesions from an occult primary gonadal neoplasm undergoing spontaneous regression [11,22]. A neoplastic transformation of pulmonary placental emboli from a previous vesicular mole, term pregnancy, abortion or ectopic pregnancy months or years before also seems possible [3,22]. Finally, the tumor could have been generated from a metaplasia or differentiation of somatic neoplastic cells like primary lung cancer [13].…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Serno¹,

Zeppernick²,

Jäkel³

et al. 2012

Gynecol Obstet Invest

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Primary pulmonary choriocarcinoma is a rare disease with only 31 reported cases in the literature so far. Here, we summarize all published cases, including a recent case of our own clinic. Patients usually presented with symptoms like dyspnea, cough, chest pain, weight loss or hemoptysis. In some cases, the nodule in the lung was found in a routine check-up in asymptomatic patients. In the present case, the patient presented to our clinic because of a positive urine pregnancy test despite taking oral contraceptives. Patients in the analyzed cases were either treated with surgery, chemotherapy, radiotherapy or best supportive care. In the present case, a complete resection of the tumor was possible and the patient has not had any signs of recurrence so far. When looking at the published cases and corresponding outcomes, a slight tendency toward a complete resection followed by chemotherapy or close follow-up examinations seems to give the patients the best survival chances. Nevertheless, the overall prognosis of primary pulmonary choriocarinoma is poor and the 5-year survival rate is below 5%.

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Section: Discussionmentioning

confidence: 99%

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Serno¹,

Zeppernick²,

Jäkel³

et al. 2012

Gynecol Obstet Invest

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“…For some authors [2][3][4][5], the diagnostic criteria would include: lack of a previous gynecological malignancy, soli tary or predominant lung lesion -with the exclusion of a gonadal primary site -, raised serum B-HCG titers that become normal after surgery and/or chemotherapy, and pathological confirmation of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent presentation is that of a pulmonary mass with hemoptysis or chest pain, and dis tant métastasés (lung, brain and kidney) are commonly present [2][3][4][5][6][7], Two relevant characteristics of choriocarci noma are the constant elevation of serum B-HCG levels (which is useful for diagnostic, prognostic and follow-up pourposes) and the bleeding tendency of the primary and metastatic sites (the choriocarcinoma syndrome) [7,11]. The adverse prognosis of trophoblastic neoplasia and cho riocarcinoma has significantly improved since the intro- duction of chemotherapy [12].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors believe that these tumors could represent nretastases from a primary gonadal (testicular or ovarian) neoplasm undergoing spon taneous regression [ 1 ]. Others believe that they are derived from a progression to malignancy of trophoblastic emboli from previous normal or molar gestations, even after long latency periods [2]. In other reports, the hypothesis of dif ferentiation or metaplasia to trophoblast from a primarylung cancer is supported [3,4], Finally, there are propo nents of their genesis from germ cells remaining after an anomalous migration during the embryonic phase [ 13],…”

Section: Discussionmentioning

confidence: 99%

“…extragonadal choriocarcinomas are even rarer, with a strong predilection for young males; most cases arise in midline structures (mediastinum, pineal gland, retroperitoneum), but have been occasional ly reported in other visceral locations (stomach, esopha gus, small bowel, prostate and urinary bladder) [1]. Iso lated descriptions (less than 20 patients) of primary cho riocarcinoma of the lung were reported in the literature [2][3][4][5][6][7], We reviewed the case records of 3 female patients with extragonadal, nongestational choriocarcinoma ap parently arising in the lung, who were treated at our insti tution between 1988 and 1994. Two of the cases were his tologically proven choriocarcinomas, and the third one had clinical features and serum B-HCG levels compatible with this neoplasm.…”

Section: Introductionmentioning

confidence: 99%

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Extragonadal Nongestational Choriocarcinoma Involving the Lung: A Report of Three Cases

Aparicio¹,

Oltra²,

Martínez‐Moragón

et al. 1996

Respiration

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Primary choriocarcinoma of the lung is an extremely rare tumour, with about 20 cases reported in the literature. The case records of 3 female patients with nongestational, extragonadal choriocarcinoma apparently arising in the lung are presented to illustrate its clinical spectrum, the utility of serum beta human chorionic gonadotropin, and responsiveness to chemotherapy. Most plausible origins of these malignancies and differential diagnosis are briefly discussed.

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Primary choriocarcinoma of the lung: Report of a case treated with intensive multimodality therapy and review of the literature

Sridhar

Saldana

Thurer

et al. 1989

Journal of Surgical Oncology

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Primary choriocarcinomas of the lung are extremely rare. Like choriocarcinomas elsewhere, they possess rapid growth ability and a high propensity to metastasize. There is minimal information available on the treatment of lung choriocarcinoma. In the case reported herein, neoadjuvant chemotherapy with 5-fluorouracil (5-FU) infusion, etoposide, and cisplatin induced a partial response permitting complete excision of a massive tumor of the right upper lobe involving the chest wall and superior vena cava. The patient relapsed with a metastasis to the brain that was surgically excised. Contralateral lung metastases were soon noted and responded well to systemic chemotherapy; yet the patient died of a new brain metastasis. To our knowledge, this is the first example of a primary choriocarcinoma of the lung treated with intensive multimodality therapy. The latter seems to offer a potential benefit if certain guidelines are followed.

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Primary choriocarcinoma of the lung

Cited by 50 publications

References 7 publications

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Primary Pulmonary Choriocarcinoma: Case Report and Review of the Literature

Extragonadal Nongestational Choriocarcinoma Involving the Lung: A Report of Three Cases

Primary choriocarcinoma of the lung: Report of a case treated with intensive multimodality therapy and review of the literature

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