Primary Cutaneous Hodgkin's Disease with Evolution to Systemic Disease

Kumar, Shimareet; Kingma, Douglas W.; Weiss, William; Jaffe, Elaine S.

doi:10.1097/00000478-199606000-00014

Cited by 33 publications

(20 citation statements)

References 19 publications

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“…We had reviewed the literature on HL specific skin involvement, and we found 20 articles reporting 26 cases including ours 1,3,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] in the last decade because we agree with other authors who consider the cases described by Sioutus et al as the first well-defined cases of HL specific to skin involvement. All the cases of HL specific to skin involvement as the first sign of the disease as in our patient can be seen in Table 1.…”

Section: Discussionsupporting

confidence: 75%

“…Primary cutaneous HL is exceedingly rare and only a few well-documented cases have claimed this diagnosis, 5,6,9,12,14,15 some of them with lately systemic involvement. Within these cases, three of the cases reported by Sioutos et al could be more accurately considered lymphomatoid papulosis because of their waxing and waning chronic clinical course.…”

Section: Discussionmentioning

confidence: 99%

“…25 Finally, in North America and western Europe, 30%-50% of HL is associated with EBV, with a rate of up to 90% in mixed cellularity subtype. 6 There are several cases of EBER and LMP1 positive HL 6,12 that strongly favor HL diagnosis over CD30 + lymphoproliferative disorders. 6 The lack of association with EBV in our patient is an infrequent feature of HL, 6 and is particularly diagnostically challenging in separating HL from cutaneous CD30 + lymphoproliferative disorders.…”

Section: Discussionmentioning

confidence: 99%

“…6 There are several cases of EBER and LMP1 positive HL 6,12 that strongly favor HL diagnosis over CD30 + lymphoproliferative disorders. 6 The lack of association with EBV in our patient is an infrequent feature of HL, 6 and is particularly diagnostically challenging in separating HL from cutaneous CD30 + lymphoproliferative disorders. The lack of spontaneous regression of the lesions in our case argues against lymphomatoid papulosis.…”

Section: Discussionmentioning

confidence: 99%

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Specific Skin Infiltration as First Sign of Localized Stage Hodgkin's Lymphoma Involving an Epitrochlear Node

Llamas‐Velasco¹,

Fraga

Pérez‐Gala

et al. 2015

The American Journal of Dermatopathology

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Cutaneous manifestation as the first sign of Hodgkin lymphoma (HL) is very rare and diagnostically challenging; especially, because the clinical presentation of specific skin involvement by HL is polymorphous. We present a 44-year-old man with erythematous indurate papules and plaques in the right forearm and arm where skin biopsy showed an HL. He also has an enlarged epitrochlear node, and later histopathologic study confirmed the diagnosis of HL subtype-mixed cellularity. Immunohisto-chemical stains in both biopsies showed that the atypical cells were positive for CD30 and CD15, and negative for CD20 and CD3. PAX5 stained the nuclei of the atypical large lymphoid cells weakly and Oct-2 staining was negative in the atypical cells. EBER and LMP1 protein were negative in both biopsies. Epitrochlear involvement in HL, like in our case, is a rare event (<1%). We reviewed data about prognosis, clinical appearance, and treatment of all the cases of HL specific skin involvement published after Sioutos et al, emphasizing the cases where HL specific skin involvement was the first sign of the disease as in our patient. Abstract: Cutaneous manifestation as the first sign of Hodgkin lymphoma (HL) is very rare and diagnostically challenging; especially, because the clinical presentation of specific skin involvement by HL is polymorphous. We present a 44-year-old man with erythematous indurate papules and plaques in the right forearm and arm where skin biopsy showed an HL. He also has an enlarged epitrochlear node, and later histopathologic study confirmed the diagnosis of HL subtype-mixed cellularity. Immunohistochemical stains in both biopsies showed that the atypical cells were positive for CD30 and CD15, and negative for CD20 and CD3. PAX5 stained the nuclei of the atypical large lymphoid cells weakly and Oct-2 staining was negative in the atypical cells. EBER and LMP1 protein were negative in both biopsies. Epitrochlear involvement in HL, like in our case, is a rare event (,1%). We reviewed data about prognosis , clinical appearance, and treatment of all the cases of HL specific skin involvement published after Sioutos et al, emphasizing the cases where HL specific skin involvement was the first sign of the disease as in our patient. (Am J Dermatopathol 2014;0:1-4)

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Specific Skin Infiltration as First Sign of Localized Stage Hodgkin's Lymphoma Involving an Epitrochlear Node

Llamas‐Velasco¹,

Fraga

Pérez‐Gala

et al. 2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9][10][11] Primary cutaneous HD is extremely rare. 9, 10 Heyd summarized 26 cases of CLHD published to 1989. 8 Although the cytologic diagnosis of HD is well established, there is no cytologic literature on CLHD, to the best of our knowledge.…”

mentioning

confidence: 99%