Primary cutaneous plasmocytoma in a patient with chronic lymphatic leukemia

Belinchón, I.; Ramos, J. J.; Onrubia, Jorge; Mayol, María José

doi:10.1016/s0190-9622(96)90751-3

Cited by 16 publications

(12 citation statements)

References 7 publications

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“…described a patient with chronic lymphocytic leukemia (CLL) who developed a PCP at the site of a previous herpes simplex lesion. Alternatively, immunologic deficiency in CLL patients or carcinogenic consequences of chemotherapy may play a role in causing the PCP . Zendri et al .…”

Section: Discussionmentioning

confidence: 99%

“…The precipitating cause of PCP has not been fully elucidated; however, immunosuppression and previous viral infections may play a role in causing some PCPs. Belinchon et al 7 described a patient with chronic lymphocytic leukemia (CLL) who developed a PCP at the site of a previous herpes simplex lesion. Alternatively, immunologic deficiency in CLL patients or carcinogenic consequences of chemotherapy may play a role in causing the PCP.…”

Section: Discussionmentioning

confidence: 99%

“…Alternatively, immunologic deficiency in CLL patients or carcinogenic consequences of chemotherapy may play a role in causing the PCP. 7 Zendri et al 8 hypothesized that viral products of HSV-1 could activate interleukin-6 (IL-6), which increases the maturation of active B cells, proliferation of malignant plasma cells, upregulation of c-myc, and bcl-2 antiapoptotic activity.…”

Section: Discussionmentioning

confidence: 99%

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Primary cutaneous plasmacytoma in an HIV‐positive patient

2015

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary cutaneous plasmacytoma in an HIV‐positive patient

2015

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“…Sixty to 80% of cases of PEP arise in the upper digestive tract, whilst primary cutaneous plasmacytoma (PCP) is rare (2–4% of all PEPs) 1 . The mucosal localization of PCP, moreover, is rare with just four cases reported in the literature 2–5 . In this report, we describe the first case of PCP of the lower lip preceded by recurrent infection with herpes simplex virus (HSV)‐1.…”

Section: Reportmentioning

confidence: 93%

Primary cutaneous plasmacytoma: a role for a triggering stimulus?

et al. 2005

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Primary cutaneous plasmacytoma is a rare type of cutaneous B-cell lymphoma, characterized by clonal proliferation of plasma cells, that primarily develops in the skin. Five cases have been described to date in which a local triggering stimulus may be involved in development of this skin tumour. We describe the case of a primary cutaneous plasmacytoma localized to the lower lip. This site had been affected for 15 years with recurrent herpes simplex virus-1 infection. Neoplastic plasma cells were found to be bcl-2-positive. We hypothesize that chronic stimulation of keratinocytes by herpes simplex virus-1, possibly through toll-like receptors, may have favoured the release of cytokines (e.g. interleukin-6) able to induce plasma cell proliferation, transformation and survival.

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“…Esses tumores são raros, correspondendo à variação de três a 12% dos casos de plasmocitomas extramedulares; têm prognóstico variável, podendo ou não ocorrer disseminação da doença. 4 Foi observado o caso de paciente com diagnóstico de mieloma múltiplo, o qual, após sete meses de evolução, apresentou plasmocitomas cutâneos. Em função da pesquisa bibliográfica nacional dos últimos 20 anos ter revelado apenas uma referência sobre plasmocitomas cutâneos associados a mieloma múltiplo, os autores resolveram relatá-lo.…”

Section: Histopathologic Exam Showed Bone Tissue Partly Substituted Bunclassified

Mieloma múltiplo com plasmocitomas cutâneos

Souza

Freitas

Paes

et al. 2004

An. Bras. Dermatol.

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Resumo: O mieloma múltiplo é neoplasia de células plasmáticas que infiltram a medula óssea; as lesões cutâneas no mieloma múltiplo são raras, inespecíficas ou específicas, sendo estas últimas primárias ou secundárias. Lesões específicas secundárias de pele em pacientes com mieloma ocorrem por extensão direta para a pele, a partir de lesões ósseas subjacentes, ou como plasmocitomas extramedulares metastáticos. Os autores relatam caso de paciente de 59 anos, que apresentou diagnóstico de mieloma múltiplo e, após sete meses de evolução, desenvolveu plasmocitomas cutâneos, caracterizados por nódulos eritêmato-violáceos nas extremidades. Palavras-chave: manifestações cutâneas; mieloma múltiplo; plasmocitoma. Abstract: Multiple myeloma is a malignant proliferation of plasma cells which infiltrate bone marrow; cutaneous involvement with plasma cell neoplasms is uncommon, and may be nonspecific or specific. The specific dermatologic lesions arise either as a direct extension from the underlying bone lesions or by metastatic accumulation in the form of nodules and plaques. The authors report the case of a 59-year-old male patient with multiple myeloma, who developed cutaneous plasmacytomas (violaceous nodules on the limbs) seven months after the disease diagnosis.

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Primary cutaneous plasmocytoma in a patient with chronic lymphatic leukemia

Cited by 16 publications

References 7 publications

Primary cutaneous plasmacytoma in an HIV‐positive patient

Primary cutaneous plasmacytoma in an HIV‐positive patient

Primary cutaneous plasmacytoma: a role for a triggering stimulus?

Mieloma múltiplo com plasmocitomas cutâneos

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