Primary Esophageal Lymphoepithelioma

Parra, P.; Aguilar, Juan; López-Garrido, Juan; Meléndez, Bárbara; Ovejero-Merino, Enrique; Martínez, Vicente; Gordillo, E; Roldán, J P

doi:10.1177/030089169908500619

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…LELC is one of the least common primary epithelial malignancies of the esophagus. Outside of Asia, the incidence of LELC is little more than anecdotal . The clinical presentation and gross appearance of this neoplasm are similar to those of conventional SCC.…”

Section: Rare Variants Of Squamous Carcinomamentioning

confidence: 89%

Rare tumors of esophageal squamous mucosa

Tripathi

Swanson

2016

Annals of the New York Academy of Sciences

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In spite of increasing incidence of esophageal adenocarcinoma in the last few decades, esophageal squamous cell carcinoma (SCC) still remains the dominant subtype of esophageal cancer worldwide. Apart from conventional SCC, some rare unconventional tumors of esophageal squamous mucosa are also well known. This study provides an introduction to these and presents a brief review of the literature, including the diagnostic and prognostic importance of each variant.

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Section: Rare Variants Of Squamous Carcinomamentioning

confidence: 89%

Rare tumors of esophageal squamous mucosa

Tripathi

Swanson

2016

Annals of the New York Academy of Sciences

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“…However, Wang et al 24 failed to demonstrate, by 2 different methods (in situ hybridization for EBER-1 transcript and PCR amplification for EBV BamHI W region), the presence of EBV in 51 cases of tumors of the esophagus, including 12 with prominent lymphoid stroma reminiscent of LELC. Accordingly, Parra et al, 11 who reported the first LELC of the esophagus in Western countries, and Sashiyama et al 12 reporting a case from Japan did not demonstrate the presence of EBV using the above-mentioned methods. Taken together, it seems plausible that EBV infection is not associated with LELC of the esophagus.…”

Section: Discussionmentioning

confidence: 98%

“…To our knowledge, only 29 cases have been reported in the literature, including the present case. [6][7][8][9][10][11][12][13][14]22 The epidemiology of LELC is somewhat similar to squamous cell carcinoma (SCC) of the esophagus. 1,23 Both neoplasms are more prevalent in China and Southeast Asia and share associated risk factors such as alcohol and tobacco use.…”

Section: Discussionmentioning

confidence: 99%

“…5 However, rare cases of LELC of the esophagus, most of them from Southeast Asian or Western European countries, have been reported in the literature. [6][7][8][9][10][11][12][13][14] Here we report, to our knowledge, the first primary LELC of the esophagus associated with EBV infection in a patient from Chile, a Latin American fairly homogeneous Hispanic country. 15 The clinicopathologic features of this case together with molecular findings, such as lack of EBER-1 expression, the gold standard for EBV detection in histopathologic lesions, 16 and the presence of the type ''i''/XhoI loss novel recombinant EBV strain 17 prompted us to report this case.…”

mentioning

confidence: 99%

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Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

Valbuena

Retamal²,

Bernal³

et al. 2007

Diagnostic Molecular Pathology

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Primary lymphoepitheliomalike carcinomas (LELC) of the esophagus are uncommon, with only 29 previously reported cases in the literature. Primary LELC of the esophagus is associated with Epstein-Barr virus (EBV). We herein report a 52-year-old man who presented with dysphagia and weight loss and was found to have a polypoid mass in the middle esophagus. Pathologic examination showed LELC. EBV infection was demonstrated by immunohistochemical detection of EBNA-1 in neoplastic cells and polymerase chain reaction amplification for EBNA-3C, BamHI-F, and W1/I1 regions but not by in situ hybridization by EBER-1 transcripts. EBV genotyping analysis demonstrated infection by a novel type "i"/XhoI loss recombinant strain. Although it is accepted that polymorphisms at BamHI-W1/I1 region cosegregate with polymorphisms at XhoI restriction site, this novel recombinant EBV has been identified in healthy donors and in nasal NK/T-cell lymphoma. To our knowledge, this is the first report that describes this recombinant type "i"/XhoI loss EBV strain in a primary LELC of the esophagus.

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“…Lymphoepithelioma‐like carcinoma has been described in various organs including the salivary gland, thymus, thyroid, breast, lung, stomach, urinary bladder, uterine cervix and skin 3–11 . According to Medline's database ‘PubMed’, 16 LELC cases arising in the esophagus have been documented in the English literature 13–23 . This includes the cases described as poorly differentiated carcinoma with prominent lymphocytic infiltration.…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma‐like carcinoma of the esophagus: Report of a case with non‐progressive behavior

Nakasono

Hirokawa

Suzuki³

et al. 2007

J of Gastro and Hepatol

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Lymphoepithelioma-like carcinoma (LELC) of the esophagus is extremely rare and the prognosis has been described to be favorable. Herein, the case is reported of esophageal LELC showing non-progressive course for 1 year. The patient was a 70-year-old Japanese man with a submucosal tumor in the lower esophagus. The tumor was endoscopically regarded as a benign leiomyoma. One year after the first endoscopic examination, the size of the lesion remained unchanged despite no treatment. Histologically, the tumor showed undifferentiated carcinoma associated with dense lymphocytic and plasma cell infiltration. Lymphoid follicles surrounded the tumor cell nests. Immunohistochemically, Ki-67 labeling index of the tumor cells were 76.0%, and there were few single-strand DNA-positive apoptotic cells. In situ hybridization using a digoxigen-labeled Epstein-Barr virus (EBV)-encoded small RNA (EBER)-1 riboprobe failed to detect the presence of EBV infection. Physicians should be aware that esophageal LELC endoscopically mimics benign submucosal tumor. This case may demonstrate that esophageal LELC is a slow-growing tumor and it is related to immune reaction.

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Primary Esophageal Lymphoepithelioma

Cited by 9 publications

References 12 publications

Rare tumors of esophageal squamous mucosa

Rare tumors of esophageal squamous mucosa

Epstein-Barr Virus-associated Primary Lymphoepitheliomalike Carcinoma of the Esophagus

Lymphoepithelioma‐like carcinoma of the esophagus: Report of a case with non‐progressive behavior

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