Primary Lymphoma of the Endometrium

Cahill, Leigh Ann; Stastny, Janet F.; Frable, William J.

doi:10.1159/000332552

Cited by 15 publications

(6 citation statements)

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“…Grossly, primary cervical lymphomas usually present as diffuse enlargement, a polyp or a solitary mass. Mucosal lesions are uncommon, thus hampering diagnosis by Pap test or superficial cervical biopsy in the absence of ulceration . The high incidence of benign lymphoid aggregates in this area further complicates diagnosis of cervical lymphomas…”

Section: Discussionmentioning

confidence: 99%

“…Mucosal lesions are uncommon, thus hampering diagnosis by Pap test or superficial cervical biopsy in the absence of ulceration. 13 The high incidence of benign lymphoid aggregates in this area further complicates diagnosis of cervical lymphomas. 14 The most frequently encountered primary cervical lymphomas are diffuse large B-cell lymphoma, followed by follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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Primary B‐cell lymphoma of the uterine cervix: Presentation in Pap‐test slide and cervical biopsy

Yang

Deisch

Tavares

et al. 2016

Diagnostic Cytopathology

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This case involved a 69-year-old female who presented with irritative urinary voiding. Imaging studies showed an 18-cm uterine mass centering on the cervix and extending into the bladder. The Pap test slide demonstrated necrotic background and degenerative changes in single and grouped atypical "small round blue cells" with high nuclear/cytoplasm ratio, scant cytoplasm, and hyperchromatic focally cleaved nuclei with occasional nuclear membrane "snout projections." Cervical biopsies showed similar findings. The tumor cells were positive for CD45, CD20, and PAX-5, and negative with epithelial, neuroendocrine, and muscle markers. A Ki-67 immunostain showed a markedly elevated proliferative index and the MUM1 stain was diffusely positive. Molecular study identified clonal immunoglobulin heavy chain gene rearrangement. Owing to its rarity, cervical lymphoma may sometimes be confused with other types of malignant neoplasms or inflammatory processes. Therefore, it is important to recognize the cytological features of cervical lymphomas and be aware of the potential diagnostic pitfalls for timely diagnosis and therapy. Diagn. Cytopathol. 2017;45:235-238. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Primary B‐cell lymphoma of the uterine cervix: Presentation in Pap‐test slide and cervical biopsy

Yang

Deisch

Tavares

et al. 2016

Diagnostic Cytopathology

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“…The diagnostic features on cervicovaginal cytology are the presence of monomorphic cell population, high nuclear/cytoplasmic ratio, scant rim of cytoplasm, coarsely granular nuclear chromatin with chromatin clumping and the presence of prominent nucleoli. [1] Follicular or chronic cervicitis, small cell carcinoma, endometrial stromal sarcoma and granulocytic sarcoma should be considered among the differential diagnosis of this entity. In follicular or chronic cervicitis, numerous plasma cells and a polymorphous infiltrate of mature and immature lymphocytes generally forming lymphoid follicles are the frequently encountered findings in contrast to ML.…”

Section: Discussionmentioning

confidence: 99%

“…[1] Non-Hodgkin's lymphoma (NHL) arising from extranodal organs including female genital tract is an extremely rare entity. [23] Accordingly, only 0.5% of the extranodal lymphomas involve uterine cervix and corpus.…”

Section: Introductionmentioning

confidence: 99%

“…[4] However, in the setting of a ML of the female genital tract, cervicovaginal cytology usually appears to be non-diagnostic due to the predominant subepithelial involvement by this tumor unless the mucosal surface undergoes ulceration with consequent spillover of malignant cells throughout the genital tract. [1] The present case report describes a postmenopausal patient with a NHL of the genital tract initially diagnosed through examination of the cervicovaginal smear.…”

Section: Introductionmentioning

confidence: 99%

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Non-Hodgkin′s lymphoma: A rare diagnosis on cervicovaginal cytology

Yalta

Taştekin

Puyan

et al. 2012

J Cytol

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Cervicovaginal smear screening is well known to reduce morbidity and mortality rates of invasive cervical carcinoma. Herein, we report a case of 56-year-old woman whose cervicovaginal smear was found to consist of malignant cells characterized by high nuclear/cytoplasmic ratio, scant rim of cytoplasm, coarsely granular nuclear chromatin and irregular nuclear membrane that were all reminiscent of a malignant lymphoma. Histopathological examination of the hysterectomy and unilateral adnexectomy specimen confirmed the presence of a diffuse large B-cell non Hodgkin's lymphoma involving the cervix, endometrium, myometrium, serosa and the right ovary.

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Lymphoma at uncommon sites

Young

1999

Hematol. Oncol.

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Primary Lymphoma of the Endometrium

Cited by 15 publications

References 1 publication

Primary B‐cell lymphoma of the uterine cervix: Presentation in Pap‐test slide and cervical biopsy

Primary B‐cell lymphoma of the uterine cervix: Presentation in Pap‐test slide and cervical biopsy

Non-Hodgkin′s lymphoma: A rare diagnosis on cervicovaginal cytology

Lymphoma at uncommon sites

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