Primary renal angiosarcoma

Abstract

Primary renal Angiosarcoma is a rare neoplasm and only 24 cases have been reported in specialized literature. We describe a case of primary renal angiosarcoma in a patient presenting with hematuria, palpable abdominal mass, left flank pain and anemia. A computerized tomography of the abdomen with contrast medium showed a tumor with 15 cm diameter, in the upper pole of the left kidney, with a low-density central area, suggesting necrosis or hemorrhage. Diagnosis was given in a morphologic base and proven by an immunohistochemical study. Primary renal angiosarcoma should be included among differential diagnosis of retroperitoneal hematoma and hemorrhagic renal tumors.

Primary Renal Angiosarcoma with Extensive Necrosis: A Difficult Diagnosis

“…Our patient did not have a history of exposure to any of these risk factors. Similar to our case, most primary renal angiosarcomas have already metastasized at the time of diagnosis [1, 4, 9]. The most common symptoms at presentation are of hematuria, palpable mass, and flank pain [7, 9].…”

Renal primary angiosarcoma

“…The most common clinical manifestations at the time of diagnosis are the presence of haematuria, palpable mass and flank pain [3], which do not appear in our case. However, other manifestations that have previously been described are in fact present in our case such as fever, urethral obstruction, retroperitoneal haematoma due to rupture of the tumour, constitutional syndrome and cough with haemoptisis.…”

“…It most commonly presents as macroscopic haematuria (81%), pain in the flank (38%) or a palpable kidney mass (31%) [3]. Diagnostic suspicion is based on radiological findings and confirmation is histological.…”

Primary renal angiosarcoma with extensive hemorrhage: CT and MRI findings

“…Angiosarcoma is an aggressive malignant neoplasm originating from endothelial cells of the blood and lymphatic vessels (5, 6). Among the various malignant tumors that can occur in the kidney, primary angiosarcomas are extremely rare, with only about 64 cases reported to date in the literature (3).…”