Primary small cell carcinoma of the breast: Report of seven cases and review of the literature

Kanat, Özkan; Kilickap, Saadetin; Korkmaz, Taner; Öven, Bala Başak; Canhoroz, Mustafa; Çubukçu, Erdem; Tolunay, Şahsine; Evrensel, Türkkan; Manavoğlu, Osman

doi:10.1177/030089161109700410

Cited by 23 publications

(40 citation statements)

References 32 publications

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“…However, previous reports show that the prognosis can be better if such tumors are detected at an earlier stage. According to previous reports[1]–[2],[6]–[38], the mean follow-up time was 21 months (range, 3 to 60 months), the metastasis or relapse rate was 35.7% (20/56), and the mortality was 19.6% (11/56). The most common sites of metastasis were the liver, brain, bone, lungs, and lymph nodes.…”

Section: Discussionmentioning

confidence: 86%

“…In particular, primary SCC of the breast is considerably rare. To our knowledge, 56 cases have been reported in the literature[1]–[2],[6]–[38]. In summarizing the clinicopathologic characteristics of these cases, most of them are found in women; only two male cases have been reported[6],[26].…”

Section: Discussionmentioning

confidence: 97%

“…We also reviewed previous immunohistochemical reports[1]–[2],[6]–[38]. The tumor cells from approximately 28.8% (15/52) of reported patients were positive for either ER or PR.…”

Section: Discussionmentioning

confidence: 98%

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A case report of primary small cell carcinoma of the breast and review of the literature

Ge¹,

Lv²,

Cao³

et al. 2012

Chin J Cancer

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Primary small cell carcinoma (SCC) of the breast, an exceedingly rare and aggressive tumor, is often characterized by rapid progression and poor prognosis. We report a case of primary SCC of the breast that was diagnosed through pathologic and immunohistochemical examinations. Computed tomography (CT) scans failed to reveal a non-mammary primary site. Due to the scant number of relevant case summaries, this type of tumor is proved to be a diagnostic and therapeutic challenge. Therefore, we also reviewed relevant literature to share expertise in diagnosis, clinicopathologic characteristics, treatment, and prognosis of this type of tumor. Future studies with more cases are required to define more appropriate treatment indications for this disease.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

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A case report of primary small cell carcinoma of the breast and review of the literature

Ge¹,

Lv²,

Cao³

et al. 2012

Chin J Cancer

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“…Numerous cases were amenable to surgery as the disease was localized to the breast with some patients receiving adjuvant chemotherapy and/or radiation therapy if a lumpectomy was performed. 7,13,15 Other clinicians treated their patients with chemotherapy standardized for small cell lung carcinoma using cisplatin/etoposide, carboplatin/etoposide, fluorouracil/epirubicin/cyclophosphamide, or docetaxel/carboplatin. 7,10-12 Some physicians used concurrent chemotherapy and radiation with cisplatin and etoposide.…”

Section: Discussionmentioning

confidence: 99%

“…7,13,15 Other clinicians treated their patients with chemotherapy standardized for small cell lung carcinoma using cisplatin/etoposide, carboplatin/etoposide, fluorouracil/epirubicin/cyclophosphamide, or docetaxel/carboplatin. 7,10-12 Some physicians used concurrent chemotherapy and radiation with cisplatin and etoposide. 14,15 …”

Section: Discussionmentioning

confidence: 99%

A Case of Small Cell Cancer of the Breast in a Male with Synchronous Stage IV Non-Small Cell Lung Carcinoma

2013

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Extrapulmonary small cell carcinomas (EPSCC) are extremely rare. Most reports indicate success with therapy directed at the tumor as if it was pulmonary small cell carcinoma Primary small cell carcinoma of the breast is an uncommon form of EPSCC. Differentiating between a primary small cell carcinoma of the breast from metastatic disease to the breast is very important. According to the literature, there have been approximately 70 cases reported worldwide. Of these cases, only two cases are documented in men. Prognosis is varied and depends on stage of disease at presentation. A combination of surgery, chemotherapy and/or radiation is required to adequately treat patients with small cell carcinoma of the breast. We present a case of a male patient diagnosed with stage IV non-small cell lung carcinoma first and then subsequently diagnosed with a concurrent small cell carcinoma of the breast responding to treatment with concurrent chemotherapy and radiation.

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Two cases of primary small cell carcinoma of the breast showing non-mass-like pattern on diagnostic imaging and histopathology

et al. 2012

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Primary small cell carcinoma of the breast is a rare breast cancer. We report two cases of this entity showing a non-mass-like pattern on multimodality images and histopathology. Both women presented with a breast mass, and one had axillary lymphadenopathy. Both cases revealed fine calcification on mammography (MMG) and an irregularly shaped, hypoechoic lesion on ultrasonography. Computed tomography (CT) and magnetic resonance imaging (MRI) showed non-mass-like enhancement in both cases. Dynamic MRI showed medium initial enhancement followed by persistent delayed enhancement in one patient, whereas rapid initial enhancement with plateau delayed enhancement was observed in the other. The breast lesions showed very high signal intensity on diffusion-weighted MRI. Positron emission tomography showed moderate accumulation of 2-fluoro-2-deoxyglucose in the breast tumor and lymph node metastasis. The non-mass-like enhancement on CT and MRI and the segmental fine calcification on MMG indicate the abundance of components of ductal carcinoma in situ and the breast origin of the small cell carcinoma.

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Primary small cell carcinoma of the breast: Report of seven cases and review of the literature

Cited by 23 publications

References 32 publications

A case report of primary small cell carcinoma of the breast and review of the literature

A case report of primary small cell carcinoma of the breast and review of the literature

A Case of Small Cell Cancer of the Breast in a Male with Synchronous Stage IV Non-Small Cell Lung Carcinoma

Two cases of primary small cell carcinoma of the breast showing non-mass-like pattern on diagnostic imaging and histopathology

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