Primary Squamous Cell Carcinoma of Submandibular Salivary Gland with Sialo-Cutaneous Fistula: A Rare Case Report

Kulkarni, Aditya; Thakur, Sanjiv

doi:10.7860/jcdr/2015/14017.6409

Cited by 4 publications

(10 citation statements)

References 10 publications

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“…While all metastatic SCCs involved the parotid gland, primary SCCs affected both parotid and submandibular glands. The parotid gland is the most commonly involved major gland in primary SCC [1,3,14], although many isolated cases of submandibular gland origin have been reported [4,5,16,22,23]. The location of primary SCC as well as the age and sex of the patients were similar to those reported for salivary duct carcinomas.…”

Section: Discussionsupporting

confidence: 60%

“…The purpose of this study was to share helpful histologic features and diagnostic challenges between primary SCC and metastatic SCC of the salivary gland. Though previous studies researched variable kinds of salivary gland tumors including primary and metastatic tumors, the present series studied only SCCs of the salivary gland [ 6 , 14 - 16 ]. Therefore, primary SCCs of this study comprised a higher proportion (8 of 16 cases, 50%) among the total SCCs of the salivary gland retrieved over a 19-year period at one institution ( Tables 1 , 2 ).…”

Section: Discussionmentioning

confidence: 99%

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Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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Background Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease. Methods Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups. Results Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively. Conclusions A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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“…5 Sialocutaneous fistula is a very rare complication. Sialocutaneous fistula can be associated with tumorous conditions, 6 but to our knowledge, there was no case involved with giant sialolith excepting one megalith case with sialocutaneous and sialo-oral fistula. 7 It is possible that an impacted stone obstructing the submandibular duct resulted in stasis, infection, and subsequent skin rupture.…”

Section: Sialolith: How Big?mentioning

confidence: 72%

Sialolith: How Big?

Kim

Choi

2019

Ear Nose Throat J

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“…Out of all the reported cases, many patients presented with either an early secondary pulmonary metastasis or recurrence of the lesion with dismal outcomes [3,4,6,[8][9][10][11][12][13][14]. The reported survival rate of the patients with PSCC of MSG is 50% to 80% for low-grade tumors and around 14% for high-grade tumors [15].…”

Section: Discussionmentioning

confidence: 99%

“…The characteristic presentation of PSCC of SSG is an asymptomatic progressive swelling, rarely tender, often fixed in the submandibular region. It most commonly occurs in the sixth decade of life with a distinct male predilection [ 4 ]. Our case carries a similar presentation of the disease.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: Brief Overview of Diagnostic Ambiguity and Treatment Challenges

Hingnikar¹,

Jadhav²,

Bhola³

2022

Cureus

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Primary squamous cell carcinoma of the submandibular salivary gland is a rarity with obscure etiology and atypical presentation. The features include a progressively enlarging swelling in the lateral neck just below the mandible, which is rarely tender. Surgery is the mainstay of the treatment, and the role of adjuvant therapies is not defined. Precise diagnosis demands a step-by-step systematic approach to exclude the presence of any index tumor. A 65-year-old countryside male presented to our institute with a complaint of submandibular swelling of the right side. After the exclusion of the primary, he was treated surgically with safe margins, ipsilateral comprehensive neck dissection, and adjuvant therapy. One month postchemoradiotherapy, the patient developed a second primary in the contralateral submandibular region with lung metastasis and succumbed to death due to malignant cachexia. The stage of the disease at presentation, bone and skin involvement, lymphovascular invasion, poorer differentiation, and distant metastasis are associated with dismal outcomes. An early diagnosis and comprehensive surgical management with adjuvant chemoradiotherapy must be accomplished.

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Primary Squamous Cell Carcinoma of Submandibular Salivary Gland with Sialo-Cutaneous Fistula: A Rare Case Report

Cited by 4 publications

References 10 publications

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Sialolith: How Big?

A Rare Case of Primary Squamous Cell Carcinoma of the Submandibular Salivary Gland: Brief Overview of Diagnostic Ambiguity and Treatment Challenges

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