Primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis: An unusual case

Abstract

Although a rare breast cancer subtype, SCCB is of considerable interest due to its pathological heterogeneity and differences in clinical behavior and less reported occurrence of nodal metastasis.

Primitive squamous cell carcinoma of the breast (SCCB): case report of an uncommon variant of metaplastic carcinoma

“…Some authors consider that it derives from a metaplasia occurring in the course of a benign breast disease. Mitra et al (9) and Toikkanen et al (1) claim that it is linked to the neoplastic transformation of dermoid or epidermal elements, independent of the overlying skin and of the nipple-areola complex. Breast cancer is defined as a …”

Primary squamous cell carcinoma of breast: A Rare Case Report

“…Theories include malignant growth of intrinsic epidermal elements (epidermal or dermoid cysts) and metaplasia from breast parenchyma (benign disease like cystosarcoma phylloides, fibroadenomas or from breast malignancy like intraductal carcinoma) or from chronic abscess . [4,5].…”

“…Grossly, approximately 2/3 rd of these tumors are cystic or have a cystic component with central necrosis [5].…”

“…However because effective adjuvant or neoadjuvant therapy is not available, future research should focus on the molecular biology, (e.g. EGFR), to develop tumor-specific therapy [5].…”

Primary squamous cell carcinoma of the breast: a rare entity, representation of two cases

“…1 It is known to be a very aggressive which is a hormone receptor negative and is treatment refractory tumor with poor prognosis. 3 We report two cases of this rare malignancy, after radiological, histopathological and immunochemistry evaluation and review the literature for current strategies for management.…”