Priming after a Fractional Dose of Inactivated Poliovirus Vaccine

Abstract

This evaluation shows that vaccinating infants with a single fractional dose of IPV can induce priming and seroconversion in more than 90% of immunized infants. (Funded by the World Health Organization and the Pan American Health Organization; Australian New Zealand Clinical Trials Registry number, ACTRN12610001046099.).

Determination of Depth-Dependent Intradermal Immunogenicity of Adjuvanted Inactivated Polio Vaccine Delivered by Microinjections via Hollow Microneedles

“…Similarly, for polio booster immunization, intradermal 20% IPV dose resulted in either similar (6,13) or inferior (34,35) seroconversion rates in comparison to full intramuscular dose. However, intradermal immunization generally resulted in significantly lowered antibody titers (5,6,(31)(32)(33)(34)(35). These findings were seemingly not dependent on the intradermal immunization method used, because jet injectors (5,6,31,32,34,35), the Mantoux technique (4,35) or HMN arrays (13,33) evenly resulted in either similar or inferior results to full intramuscular dose.…”

“…Furthermore, clinical trials in humans have been performed to investigate IPV dose sparing, by comparison of a 80% reduced IPV dose (20% of full dose) administered intradermally against a full IPV dose administered intramuscularly. For polio prime immunization in newborn infants, intradermal 20% IPV dose resulted in similar (4,5) or inferior (31)(32)(33) seroconversion rates compared to a full intramuscular dose. Similarly, for polio booster immunization, intradermal 20% IPV dose resulted in either similar (6,13) or inferior (34,35) seroconversion rates in comparison to full intramuscular dose.…”

Intradermal vaccination using the novel microneedle device MicronJet600: Past, present, and future

“…50 Dose sparing is also important in increasing capacity and reducing the expense of a vaccine dose, especially in cost-sensitive globalhealth indications where the price of the vaccine limits its use and coverage, as in the case of polio. 51,52 Exploring the intradermal approach was recommended at a recent meeting of the World Health Organization Strategic Advisory Group of Experts (SAGE), 53 as a means to reduce dose prices to make injectable polio vaccines (IPV) affordable for successful eradication of the disease in the Polio End Game 54 A limitation of many of the studies, however, lies in the fact that they have not evaluated equivalent low-dose IM or SQ vaccination groups. 55 The most recently registered indication for intradermal vaccination is influenza, where the ID approach has actually been pursued since the 1930's.…”

Efficacy of inactivated poliovirus vaccine in India

“…A dose of IPV is expected to induce seroconversion or priming in close to 100% of naïve infants (33). Should poliovirus type 2 be reintroduced, a second IPV dose would rapidly boost antibody titers and prevent, or decrease the magnitude of, an outbreak.…”