Mutrakricchra is a broad term which covers the conditions described in modern medical science as Urinary tract infection (UTI). The pratyatma lakshana of Mutrakricchra is "dukhena mutra pravritti" means discomfort during micturition. Mutrakricchra is also found as a lakshana in many diseases such as ashmari, Mutraghata, Mutraja vridhi, arsha and Gulma etc. The present study was done to assess the etiopathology of mutrakricchra according to various classical texts and to find out interrelation between mutrakricchra and Urinary tract infection. In this review etiopathogenesis of the mutrakricchra has been illustrated in accordance with ayurvedic classics, and research papers collected from indexed journals accessed physically and through the internet. Nidanas of mutrakricchra are divided in to two types i.e. samanya and vishishta nidana. It can be classified according to the doshas i.e. vataja, pittaja and kaphaja nidana. Various scholarly articles have suggested that Excessive exercise, Medications, Alcohol, Regular intercourse, Regular riding, Sea foods, Heavy food intake & Indigestion, Salt & astringent materials, Urge suppression and Fecalith are the main etiological factors of mutrakricchra w.s.r. to Urinary tract infection. Apana vata is responsible for normal evacuation of urine. Sushruta has mentioned that the pratiloma gati of vata is responsible for the mutra rogas. So it is concluded that any abnormalities in vyana vayu, samana vayu, pachaka pitta, ranjaka pitta and apana vayu due to dietary, habitual, deficiency, injury and bacterial factors resulting in mutrakricchra.