Principles of Therapy for Lameness

Koch, Drew W.; Goodrich, Laurie R.; Smanik, Lauren E.; Steward, Sara K.T.; Ernst, Nicolas S.; Trumble, Troy N.; Parks, A. H.; Haussler, Kevin K.; King, Melissa R.; Ellis, Katherine; Stubbs, N. C.

doi:10.1002/9781119276715.ch8

Cited by 3 publications

(3 citation statements)

References 556 publications

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“…PSGAGs consist of low-molecular-weight polysulfated glycosaminoglycans (GAGs), ranging approximately from 6000 to 10,000 Da, of animal origin, closely resembling the structure of chondroitin sulfate, which is the predominant GAG found in healthy cartilage [117]. In equine medicine, PSGAG is licensed under the name Adequan ® (Luitpold Pharmaceuticals, Inc., Shirley, NY, USA) and is administered via IM.…”

Section: Psgagsmentioning

confidence: 99%

“…Its molecular structure and function closely align with those of the naturally occurring glycosaminoglycan substances that play a key role in the maintenance and repair of cartilage and connective tissues. PPS exhibits anti-inflammatory, anti-coagulant, and fibrinolytic properties and promotes the synthesis of hyaluronan, making it effective in endorsing cartilage repair, reducing cartilage fibrillation, improving joint function, and alleviating pain associated with OA [117,120]. Some studies have demonstrated that it presents more benefits than PSGAGs when administered IM.…”

Section: Ppsmentioning

confidence: 99%

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Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Reis,

Lopes,

Sousa

et al. 2024

Veterinary Sciences

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Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of equine medicine has witnessed rapid and fruitful development, resulting in a diverse range of therapeutic options for musculoskeletal problems. Staying abreast of these advancements can be challenging, prompting the need for a comprehensive review of commonly used and recent treatments. The aim is to compile current therapeutic options for managing these injuries, spanning from simple to complex physiotherapy techniques, conservative treatments including steroidal and non-steroidal anti-inflammatory drugs, hyaluronic acid, polysulfated glycosaminoglycans, pentosan polysulfate, and polyacrylamides, to promising regenerative therapies such as hemoderivatives and stem cell-based therapies. Each therapeutic modality is scrutinized for its benefits, limitations, and potential synergistic actions to facilitate their most effective application for the intended healing/regeneration of the injured tissue/organ and subsequent patient recovery. While stem cell-based therapies have emerged as particularly promising for equine musculoskeletal injuries, a multidisciplinary approach is underscored throughout the discussion, emphasizing the importance of considering various therapeutic modalities in tandem.

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Section: Psgagsmentioning

confidence: 99%

Section: Ppsmentioning

confidence: 99%

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Reis,

Lopes,

Sousa

et al. 2024

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Successful management of multilimb lameness incorporates multimodal pain control integrating different therapeutic and supportive principles often including methods of Traditional Chinese Veterinary Medicine (TCVM). 1 2 3 4 Conventional equine lameness therapy is reliant on precise diagnoses formed on the basis of the localization of pain and identification of the underlying pathology. In TCVM, the same detailed pathoanatomical understanding is not required.…”

Section: Introductionmentioning

confidence: 99%

Effect of Needle and Extracorporeal Shockwave Stimulation of Acupuncture Points on Equine Chronic Multilimb Lameness Using a Single-Formula Approach

et al. 2022

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Objective The aim of this study was to compare effects with conventional (needle and electroacupuncture, NAP) and shockwave stimulation of acupuncture points (SAP) on chronic multilimb lameness in horses. Study Design Randomized crossover block design; ten mature Standardbred mares with multilimb lameness (< 4/10) underwent 3-weekly point stimulations (NAP/SAP) selected on the basis of their uniform applicability. Groups were reversed following a washout period (9 weeks). Lameness at the trot was video recorded and quantified objectively using an inertial sensor-based system during a 4-week pre- and post-treatment period. Blinded expert review of recordings resulted in subjective qualitative (better, same, or worse) and quantitative outcome measures (0–10 lameness grade). Mixed effect repeated measures analyses were performed on objective quantitative gait parameters specific to fore (Vector sum [VSHead]) and hindlimb lameness (average differences in minimum [DIFFMINPelvis] and maximum pelvic height [DIFFMAXPelvis]) Qualitative data were assessed in non-parametric tests. Results SAP had no effect on forelimb but improved hindlimb lameness (DIFFMINPelvis; p < 0.001). NAP was associated with deterioration of forelimb lameness (VSHead, p < 0.001) and had no effect on hindlimb lameness. VSHead data differed between modalities when accounting for the time of observation (interaction effect; p = 0.002). For other quantitative gait parameters, a difference between modalities was not observed. SAP was associated with greater animal comfort post-treatment compared with pre-treatment assessments (p = 0.036). Typically, improvement occurred by one and deterioration by two lameness grades. Conclusion SAP and NAP were not associated with the same treatment outcome. SAP slightly improved but did not alleviate all lameness. Given the non-invasive nature of SAP, this method may have potential in the management of chronic multilimb lameness.

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Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives – A Review

Reis,

Lopes,

Sousa

et al. 2024

Preprint

View full text Add to dashboard Cite

Musculoskeletal injuries such as equine osteoarthritis, osteoarticular defects, tendonitis/desmitis, and muscular disorders are prevalent among sport horses, with a fair prognosis for returning to exercise or previous performance levels. The field of equine medicine has witnessed rapid and fruitful development, resulting in a diverse range of therapeutic options for musculoskeletal problems. Staying abreast of these advancements can be challenging, prompting the need for a comprehensive review of commonly used and recent treatments. The aim is to compile current therapeutic options for managing these injuries, spanning from simple to complex physiotherapy techniques, conservative treatments including steroidal and non-steroidal anti-inflammatory drugs, hyaluronic acid, and polyacrylamides, to the promising regenerative therapies such as hemoderivatives and stem cell-based therapies. Each therapeutic modality is scrutinized for its benefits, limitations, and potential synergistic actions to facilitate their most effective application for intended healing/regeneration of the injured tissue/organ and subsequent patient recovery. While stem cell-based therapies emerge as particularly promising for equine musculoskeletal injuries, a multidisciplinary approach is underscored throughout the discussion, emphasizing the importance of considering various therapeutic modalities in tandem.

show abstract

Principles of Therapy for Lameness

Cited by 3 publications

References 556 publications

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review

Effect of Needle and Extracorporeal Shockwave Stimulation of Acupuncture Points on Equine Chronic Multilimb Lameness Using a Single-Formula Approach

Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives – A Review

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