Printing of Functional Structures on Molded 3D Devices

Polzinger, Bernhard; Matic, Vladimir; Liedtke, Laura; Keck, Juergen; Hera, Daniel; Günther, Thomas; Eberhardt, W.; Kück, H.

doi:10.4028/www.scientific.net/amr.1038.37

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…As a mask-less and fully additive printing technology with a short process chain and with a wide variety of available nanoparticle-based inks it is particularly interesting for the cost-efficient fabrication of electronic components [6][7][8] and for various biosensing applications [9,10]. The non-contact process also allows the deposition of functional materials onto 2.5D and 3D surfaces [11,12], e.g., printing into cavities. Gold is a commonly used material for electrodes in biochemical and biomedical applications because of its inertness and the possibility to functionalize it with the well-known thiol-chemistry [13].…”

Section: Introductionmentioning

confidence: 99%

Inkjet-Printing of Nanoparticle Gold and Silver Ink on Cyclic Olefin Copolymer for DNA-Sensing Applications

Trotter

Juric

Bagherian

et al. 2020

Sensors

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Inkjet technology as a maskless, direct-writing technology offers the potential for structured deposition of functional materials for the realization of electrodes for, e.g., sensing applications. In this work, electrodes were realized by inkjet-printing of commercial nanoparticle gold ink on planar substrates and, for the first time, onto the 2.5D surfaces of a 0.5 mm-deep microfluidic chamber produced in cyclic olefin copolymer (COC). The challenges of a poor wetting behavior and a low process temperature of the COC used were solved by a pretreatment with oxygen plasma and the combination of thermal (130 • C for 1 h) and photonic (955 mJ/cm 2 ) steps for sintering. By performing the photonic curing, the resistance could be reduced by about 50% to 22.7 µΩ cm. The printed gold structures were mechanically stable (optimal cross-cut value) and porous (roughness factors between 8.6 and 24.4 for 3 and 9 inkjet-printed layers, respectively). Thiolated DNA probes were immobilized throughout the porous structure without the necessity of a surface activation step. Hybridization of labeled DNA probes resulted in specific signals comparable to signals on commercial screen-printed electrodes and could be reproduced after regeneration. The process described may facilitate the integration of electrodes in 2.5D lab-on-a-chip systems.

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Section: Introductionmentioning

confidence: 99%

Inkjet-Printing of Nanoparticle Gold and Silver Ink on Cyclic Olefin Copolymer for DNA-Sensing Applications

Trotter

Juric

Bagherian

et al. 2020

Sensors

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“…Basically, a biochip is made up of two formats: first, biochip including PCR product of 100–200 base pairs, fixed along the length of the macromolecule via covalently bounds on the surface, that known as c-DNA arrays. Second (as exhibited in Figure 4), oligonucleotide probes may either be synthesized on the array (Keck et al , 2016; Polzinger et al , 2014). Initially, various gene sequences will be chosen from the DNA database based on a specific target, such as polymorphism of a gene, mutation identification and differential of a given group of genes (Moya et al , 2016; Nunes et al , 2010).…”

Section: Dna Chip Engineeringmentioning

confidence: 99%

A technique of a “lab-on-a-chip” for developing a novel biosensor in viewpoint of health-care (PHC) applications and biological regulator sensors

Monajjemi,

Mollaamin

2024

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Purpose Recently, powerful instruments for biomedical engineering research studies, including disease modeling, drug designing and nano-drug delivering, have been extremely investigated by researchers. Particularly, investigation in various microfluidics techniques and novel biomedical approaches for microfluidic-based substrate have progressed in recent years, and therefore, various cell culture platforms have been manufactured for these types of approaches. These microinstruments, known as tissue chip platforms, mimic in vivo living tissue and exhibit more physiologically similar vitro models of human tissues. Using lab-on-a-chip technologies in vitro cell culturing quickly caused in optimized systems of tissues compared to static culture. These chipsets prepare cell culture media to mimic physiological reactions and behaviors. Design/methodology/approach The authors used the application of lab chip instruments as a versatile tool for point of health-care (PHC) applications, and the authors applied a current progress in various platforms toward biochip DNA sensors as an alternative to the general bio electrochemical sensors. Basically, optical sensing is related to the intercalation between glass surfaces containing biomolecules with fluorescence and, subsequently, its reflected light that arises from the characteristics of the chemical agents. Recently, various techniques using optical fiber have progressed significantly, and researchers apply highlighted remarks and future perspectives of these kinds of platforms for PHC applications. Findings The authors assembled several microfluidic chips through cell culture and immune-fluorescent, as well as using microscopy measurement and image analysis for RNA sequencing. By this work, several chip assemblies were fabricated, and the application of the fluidic routing mechanism enables us to provide chip-to-chip communication with a variety of tissue-on-a-chip. By lab-on-a-chip techniques, the authors exhibited that coating the cell membrane via poly-dopamine and collagen was the best cell membrane coating due to the monolayer growth and differentiation of the cell types during the differentiation period. The authors found the artificial membrane, through coating with Collagen-A, has improved the growth of mouse podocytes cells-5 compared with the fibronectin-coated membrane. Originality/value The authors could distinguish the differences across the patient cohort when they used a collagen-coated microfluidic chip. For instance, von Willebrand factor, a blood glycoprotein that promotes hemostasis, can be identified and measured through these type-coated microfluidic chips.

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“…The selection of the right MID substrate is often a very challenge process that should be a balance between electrical, thermal and mechanical properties and the manufacturing cost [ 59 , 60 , 61 , 62 ].…”

Section: Materials Properties and Characteristics For Mid Substratementioning

confidence: 99%

3D-MID Technology for Surface Modification of Polymer-Based Composites: A Comprehensive Review

et al. 2020

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The three-dimensional molded interconnected device (3D-MID) has received considerable attention because of the growing demand for greater functionality and miniaturization of electronic parts. Polymer based composite are the primary choice to be used as substrate. These materials enable flexibility in production from macro to micro-MID products, high fracture toughness when subjected to mechanical loading, and they are lightweight. This survey proposes a detailed review of different types of 3D-MID modules, also presents the requirement criteria for manufacture a polymer substrate and the main surface modification techniques used to enhance the polymer substrate. The findings presented here allow to fundamentally understand the concept of 3D-MID, which can be used to manufacture a novel polymer composite substrate.

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Printing of Functional Structures on Molded 3D Devices

Cited by 10 publications

References 10 publications

Inkjet-Printing of Nanoparticle Gold and Silver Ink on Cyclic Olefin Copolymer for DNA-Sensing Applications

Inkjet-Printing of Nanoparticle Gold and Silver Ink on Cyclic Olefin Copolymer for DNA-Sensing Applications

A technique of a “lab-on-a-chip” for developing a novel biosensor in viewpoint of health-care (PHC) applications and biological regulator sensors

3D-MID Technology for Surface Modification of Polymer-Based Composites: A Comprehensive Review

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