Prior tuberculin skin testing does not boost QuantiFERON-TB results in paediatric contacts: Table 1—

Richeldi, Luca; Bergamini, Barbara Maria; Vaienti, Francesca

doi:10.1183/09031936.00014508

Cited by 22 publications

(14 citation statements)

References 8 publications

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“…28,29 However, others have reported no effect of a prior TST on a subsequent QFT-G test. 30,31 Our results were consistent with the latter reports as there was no evidence of QFT-G responses at the second round of testing being boosted by a TST placed approximately 3 weeks earlier. Only 2 of the 298 children tested by QFT-G at this time point converted to a positive result, both had large increases in the QFT-G response and one was a close contact of the index case.…”

Section: Discussionsupporting

confidence: 94%

Contact investigation in a primary school using a whole blood interferon-gamma assay

Higuchi

Kondo²,

Wada

et al. 2009

Journal of Infection

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Section: Discussionsupporting

confidence: 94%

Contact investigation in a primary school using a whole blood interferon-gamma assay

Higuchi

Kondo²,

Wada

et al. 2009

Journal of Infection

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“…Some studies have reported increased positive IFN-g responses after TST, 28,29 whereas others have not. 30,31 Leyten and colleagues 32 reported no evidence of a boosting of QFT-GIT responses in subjects undergoing TST 3 days before IGRA. Although we cannot exclude the possibility that baseline QFT-GIT responses were boosted by TST, any such effect would have applied equally to subjects receiving IPT or observation alone.…”

Section: Quantitative Qft-git Resultsmentioning

confidence: 99%

Effect of Isoniazid Therapy for Latent TB Infection on QuantiFERON-TB Gold In-Tube Responses in Adults With Positive Tuberculin Skin Test Results in a High TB Incidence Area

Johnson

Geldenhuys

Thiel

et al. 2014

Chest

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“…After reviewing these, we identified 4 studies [2], [3], [15], [16] on within-person variability, and 13 studies [2], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28] on potential boosting of IGRA results by TST (Figure 1 shows the study selection flow chart). In all, these studies included a total of 1460 subjects.…”

Section: Resultsmentioning

confidence: 99%

Within-Subject Variability of Interferon-g Assay Results for Tuberculosis and Boosting Effect of Tuberculin Skin Testing: A Systematic Review

et al. 2009

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BackgroundVariability in interferon-gamma release assays (IGRAs) results for tuberculosis has implications for interpretation of results close to the cut-point, and for defining thresholds for test conversion and reversion. However, little is known about the within-subject variability (reproducibility) of IGRAs. Several national guidelines recommend a two-step testing procedure (tuberculin skin test [TST] followed by IGRA) for the diagnosis of LTBI. However, the effect of a preceding TST on subsequent IGRA results has been reported in studies with apparently conflicting results.Methodology/FindingsWe conducted a systematic review to synthesize evidence on within-subject variability of IGRA results and the potential boosting effect of TST. We searched several databases and reviewed citations of previous reviews on IGRAs. We included studies using commercial IGRAs, in addition to non-commercial versions of the ELISPOT assay. Four studies, fulfilling our predefined criteria, examined within-subject variability and 13 studies evaluated TST effects on subsequent IGRA responses. Meta-analysis was not considered appropriate because of heterogeneity in study methods, assays, and populations. Although based on limited data, within-subject variability was present in all studies but the magnitude varied (16-80%) across studies. A TST induced “boosting” of IGRA responses was demonstrated in several studies and although more pronounced in IGRA-positive (i.e. sensitized) individuals, also occurred in a smaller but not insignificant proportion of IGRA-negative subjects. The TST appeared to affect IGRA responses only after 3 days and may apparently persist for several months, but evidence for this is weak.Conclusions/SignificanceAlthough reproducibility data are scarce, significant within person IGRA variability has been reported. If confirmed in more studies, this has implications for the interpretation of results close to the cut-point and for definition of conversions and reversions. Although the effect of TST on IGRA results is likely to be inconsequential in IGRA-positive subjects, in IGRA-negative subjects, the interpretation of results may be confounded by a preceding TST if administered more than 3 days prior to an IGRA.

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Prior tuberculin skin testing does not boost QuantiFERON-TB results in paediatric contacts: Table 1—

Cited by 22 publications

References 8 publications

Contact investigation in a primary school using a whole blood interferon-gamma assay

Contact investigation in a primary school using a whole blood interferon-gamma assay

Effect of Isoniazid Therapy for Latent TB Infection on QuantiFERON-TB Gold In-Tube Responses in Adults With Positive Tuberculin Skin Test Results in a High TB Incidence Area

Within-Subject Variability of Interferon-g Assay Results for Tuberculosis and Boosting Effect of Tuberculin Skin Testing: A Systematic Review

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