The objective of this research was to evaluate how university support and teaching entrepreneurial competencies affect students' entrepreneurial com-petencies. As an empirical test, a sample of 201 software engineering and graphic design students from a university in Northwest Mexico was taken, where it was possible to corroborate three hypotheses. The results suggest that entrepreneurial competencies are influenced by external aspects, where the university can be understood as an open system, but also, as a part of a wider system within the triple helix. This shows that the joint work between the contextual and individual part can benefit the generation of innovation and development for society, especially in a country where there is a lack of R&D, although the practice of entrepreneurship is high. As a result, the uni-versity can play a relevant role when developing entrepreneurial competen-cies to train students to become entrepreneurs through innovation and tech-nology.