Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity

Spoto, Belinda; Betta, Ernesto Di; Mattace-Raso, Francesco; Sijbrands, Eric J.G.; Vilardi, Antonio; Parlongo, Rosa Maria; Pizzini, Patrizia; Pisano, Anna; Vermi, William; Testa, Alessandra; Cutrupi, Sebastiano; D’Arrigo, Graziella; Lonardi, Silvia; Tripepi, Giovanni; Cancarini, Giovanni; Zoccali, Carmine

doi:10.1016/j.numecd.2014.04.017

Cited by 68 publications

(61 citation statements)

References 30 publications

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“…However when released in excess, they can cause unwanted exacerbation of inflammation. 6 This is particularly harmful when there is a pre-existing low-grade inflammation as in several chronic diseases. 7 The crystal structures of the two cytokines as published in the protein data bank (PDB) are depicted in Fig 1 and Fig 2.…”

Section: Introductionmentioning

confidence: 99%

Exercise and the cytokines-interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α): A review

Vijayaraghava

Doreswamy

2017

Ann Med Physiol.

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Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were one of the first few cytokines to be discovered. The normative data for levels of cytokines IL-6 and TNF-α in particular and all other cytokines in general have not yet been established well. The normal levels for each of the cytokines vary from one race to another. Therefore, all studies need to be done in cases and controls belonging to the same race or same populations. The kits for cytokine assays are expensive and running the assays is laborious and time consuming. It is recommended that the serum/plasma samples are run in duplicates and triplicates to avoid error. Immunology and the field of cytokines is an area which has many domains unexplored. As yet, it is not clearly understood by what mechanisms and pathways each of the cytokines alter the levels of other cytokines. Exercise or physical activity is an intervention which can be administered easily and levels of cytokines measured before and after intervention in same individuals taking all the above mentioned factors into consideration. Hence it is imperative that we look into studies on exercise and cytokines to do further research in the field of cytokines.

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Section: Introductionmentioning

confidence: 99%

Exercise and the cytokines-interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α): A review

Vijayaraghava

Doreswamy

2017

Ann Med Physiol.

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“…This has mainly been attributed to the relation between visceral adiposity and systemic inflammation . However, a recent study suggested that the production of inflammatory cytokines was actually higher in subcutaneous as compared to visceral adipose tissue …”

Section: Association Of Abnormalities In Body Composition With Other mentioning

confidence: 99%

Three compartment bioimpedance spectroscopy in the nutritional assessment and the outcome of patients with advanced or end stage kidney disease: What have we learned so far?

Broers

Canaud

Dekker

et al. 2020

Hemodialysis International

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Bioimpedance spectroscopy (BIS) is an easily applicable tool to assess body composition. The three compartment model BIS (3C BIS) conventionally expresses body composition as lean tissue index (LTI) (lean tissue mass [LTM]/height in meters squared) and fat tissue index (FTI) (adipose tissue mass/ height in meters squared), and a virtual compartment reflecting fluid overload (FO). It has been studied extensively in relation to diagnosis and treatment guidance of fluid status disorders in patients with advanced-stage or end-stage renal disease. It is the aim of this article to provide a narrative review on the relevance of 3C BIS in the nutritional assessment in this population. At a population level, LTI decreases after the start of hemodialysis, whereas FTI increases. LTI below the 10th percentile is a consistent predictor of outcome whereas a low FTI is predominantly associated with outcome when combined with a low LTI. Recent research also showed the connection between low LTI, inflammation, and FO, which are cumulatively associated with an increased mortality risk. However, studies toward nutritional interventions based on BIS data are still lacking in this population. In conclusion, 3C BIS, by disentangling the components of body mass index, has contributed to our understanding of the relevance of abnormalities in different body compartments in chronic kidney disease patients, and appears to be a valuable prognostic tool, at least at a population level. Studies assessing the effect of BIS guided nutritional intervention could further support its use in the daily clinical care for renal patients.

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“…Among a panel of diabetes-related cytokines, IL-6 has drawn much attention as a pleiotropic cytokine engaged in metabolic events during T2DM [24], obesity [25,26], and impaired glucose tolerance [27], but its relevance to GDM has been unclear in previous studies [13]. Indeed, Kuzmicki et al [28,29] observed elevated IL-6 concentrations in GDM patients compared with normal pregnant women, whereas Georgiou et al [30] did not find any difference.…”

Section: Prace Oryginalnementioning

confidence: 99%

Porównanie ekspresji IL6 w leukocytach pacjentek z cukrzycą ciążową (GDM) diagnozowanych zgodnie z kryteriami Polskiego Towarzystwa Diabetologicznego z 2011 i 2014 roku

Mac-Marcjanek

Zieleniak

Woźniak

et al. 2017

Endokrynologia Polska

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Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity

Cited by 68 publications

References 30 publications

Exercise and the cytokines-interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α): A review

Exercise and the cytokines-interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α): A review

Three compartment bioimpedance spectroscopy in the nutritional assessment and the outcome of patients with advanced or end stage kidney disease: What have we learned so far?

Porównanie ekspresji IL6 w leukocytach pacjentek z cukrzycą ciążową (GDM) diagnozowanych zgodnie z kryteriami Polskiego Towarzystwa Diabetologicznego z 2011 i 2014 roku

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