Pro‐coagulant thromboelastographic features in the bulldog

Hoareau, Guillaume L.; Mellema, Matthew S.

doi:10.1111/jsap.12299

Cited by 16 publications

(24 citation statements)

References 45 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Large studies on gastrointestinal disorders in healthy brachycephalic dogs are needed. Hypomagnesemia and hypercoagulation were found in clinically healthy bulldogs compared to nonbrachycephalic control dogs and boxers . Hypertension also was reported in systemically healthy pugs, Boston terrier, French bulldogs, and bulldogs .…”

Section: Discussionmentioning

confidence: 83%

Whole‐Body Barometric Plethysmography Characterizes Upper Airway Obstruction in 3 Brachycephalic Breeds of Dogs

Liu

Adams²,

Kalmár

et al. 2016

Veterinary Internal Medicne

120

View full text Add to dashboard Cite

BackgroundA novel test using whole‐body barometric plethysmography (WBBP) was developed recently to diagnose brachycephalic obstructive airway syndrome (BOAS) in unsedated French bulldogs.Hypothesis/ObjectivesThe hypotheses of this study were: (1) respiratory characteristics are different between healthy nonbrachycephalic dogs and brachycephalic dogs; and among pugs, French bulldogs, and bulldogs; and (2) obesity and stenotic nares are risk factors for BOAS. The main objective was to establish a diagnostic test for BOAS in these 3 breeds.AnimalsA total of 266 brachycephalic dogs (100 pugs, 100 French bulldogs, and 66 bulldogs) and 28 nonbrachycephalic dogs.MethodsProspective study. Exercise tolerance tests with respiratory functional grading, and WBBP were performed on all dogs. Data from WBBP were associated with functional grades to train quadratic discriminant analysis tools to assign dogs to BOAS+ and BOAS‐ groups. A BOAS index (0–100%) was calculated for each dog. Receiver operating characteristic (ROC) curves were used to evaluate classification ability.ResultsMinute volume was decreased significantly in asymptomatic pugs (P = .009), French bulldogs (P = .026), and bulldogs (P < .0001) when compared to nonbrachycephalic controls. Respiratory characteristics were different among breeds and affected dogs had a significant increase in trace variation. The BOAS index predicted BOAS status for each breed with 94–97% (95% confidence interval [CI], 88.9–100%) accuracy (area under the ROC curve). Both obesity (P = .04) and stenotic nares (P = .004) were significantly associated with BOAS.Conclusions and Clinical ImportanceThe WBBP can be used as a clinical tool to diagnose BOAS noninvasively and objectively.

show abstract

Section: Discussionmentioning

confidence: 83%

Whole‐Body Barometric Plethysmography Characterizes Upper Airway Obstruction in 3 Brachycephalic Breeds of Dogs

Liu

Adams²,

Kalmár

et al. 2016

Veterinary Internal Medicne

120

View full text Add to dashboard Cite

show abstract

“…In man, OSA causes morbidity through tiredness and a reduced lifespan and is associated with vascular and cardiac disorders . Data suggest that these associations may be present in dogs as well …”

Section: Introductionmentioning

confidence: 99%

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

2018

View full text Add to dashboard Cite

Objective: To describe sleep-disordered breathing (SDB) in the Cavalier King Charles spaniel (CKCS). Study design: Retrospective case series. Animals: Five client-owned dogs referred for SDB. Methods: Medical records were reviewed including recheck appointments and routine preoperative and postoperative questionnaires. Whole-body barometric plethysmography was used to categorize SDB. Results: All dogs presented with multiple episodes of stertorous breathing, choking, and apnea during sleep. Severe nasal septal deviation, aberrant nasal turbinates, and soft palate elongation and thickening were noted on computed tomography and rhinoscopy of each dog. Whole-body barometric plethysmography measurements during sleep (in 3 dogs) documented periods of choking, snoring, and apnea. Treatment combined laser turbinectomy, folding flap palatoplasty, tonsillectomy, laryngeal sacculectomy, and cuneiform process resection. All dogs improved in terms of incidence and severity of sleep apnea within 1 week, with 4 of 5 dogs achieving complete resolution. Conclusion: The objective measurements used to characterize SDB in this population of CKCS provided some evidence to support an obstructive cause for this condition, which improved with surgical treatment. Clinical significance: Sleep-disordered breathing in the CKCS is a different clinical presentation of brachycephalic obstructive airway syndrome. Our finding of intranasal abnormalities in these 5 dogs with SDB provides justification for future research into its clinical significance.

show abstract

“…Hypercoagulability, measured by thromboelastography (shortened clotting times and delayed fibrinolysis), is reported in some brachycephalic dogs (Hoareau & Mellema , Crane et al . ) and the severity increases with the severity of BOAS (Crane et al .…”

Section: Pre‐existing Conditions That Influence Anaesthetic Managementmentioning

confidence: 99%

“…Hypercoagulability, measured by thromboelastography (shortened clotting times and delayed fibrinolysis), is reported in some brachycephalic dogs (Hoareau & Mellema 2015, Crane et al 2017 and the severity increases with the severity of BOAS (Crane et al 2017). In humans, hypercoagulability is associated with moderate to severe OSA (Hong et al 2017) and has been linked to an increased risk of cardiovascular disease and complications, including arterial and venous thrombosis and altered wound healing (Hong et al 2017).…”

Section: Ocular and Other Considerationsmentioning

confidence: 99%

Anaesthesia of brachycephalic dogs

Downing¹,

Gibson²

2018

J of Small Animal Practice

View full text Add to dashboard Cite

Brachycephalic breeds of dog have grown in popularity in the UK and so form an increasing proportion of cases requiring anaesthesia. These breeds are predisposed to several conditions, notably brachycephalic obstructive airway syndrome and gastro‐oesophageal reflux, that have important implications for anaesthetic management and carry high risk for complications. This review incorporates peer‐reviewed veterinary literature with clinical experience in a discussion on perioperative management of brachycephalic dogs. We focus on preoperative identification of common concurrent conditions, practical strategies for reducing anaesthetic risk and improving postoperative management. Comparisons of brachycephalic obstructive airway syndrome with the human condition of obstructive sleep apnoea are included where appropriate.

show abstract

Pro‐coagulant thromboelastographic features in the bulldog

Abstract: These findings support the concept that brachycephalic syndrome promotes a hypercoagulable phenotype similar to that observed with sleep apnoea hypopnoea syndrome in humans. The large increases in maximal amplitude observed suggest platelet hyperreactivity may play an important role.

Cited by 16 publications

References 45 publications

Whole‐Body Barometric Plethysmography Characterizes Upper Airway Obstruction in 3 Brachycephalic Breeds of Dogs

Whole‐Body Barometric Plethysmography Characterizes Upper Airway Obstruction in 3 Brachycephalic Breeds of Dogs

Sleep‐disordered breathing in the Cavalier King Charles spaniel: A case series

Anaesthesia of brachycephalic dogs

Contact Info

Product

Resources

About