Pro-guest and acyclic cucurbit[<i>n</i>]uril conjugated polymers for the controlled release of anti-tumor drugs

Jiang, Siyang; Lan, Shang Che; Mao, Dake; Yang, Xuan; Shi, Kejia; Ma, Da

doi:10.1039/c8cc05552a

Cited by 29 publications

(13 citation statements)

References 35 publications

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“…Controlled drug release was not detected at pH 7.4. The drug‐loaded citraconic amide polymer displayed efficient internalization by HeLa cells at pH 6.0, attributed to the fast degradation [43] . Supramolecular assemblies combining CB[7], CB[8], and proteins have been explored for cancer photodynamic therapy by using various photosensitizers (acridine orange, methylene blue or cationic porphyrin).…”

Section: Macrocyclesmentioning

confidence: 99%

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Saji

2022

The Chemical Record

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Supramolecules‐based drug delivery has attracted significant recent research attention as it could enhance drug solubility, retention time, targeting, and stimuli responsiveness. Among the different supramolecules and assemblies, the macrocycles and the supramolecular hydrogels are the two important categories investigated to a greater extent. Here, we provide the most recent advancements in these categories. Under macrocycles, reports on drug delivery by cyclodextrins, cucurbiturils, calixarenes/pillararenes, crown ethers and porphyrins are detailed. The second category discusses the supramolecular hydrogels of macrocycles/polymers and low molecular weight gelators. The updated information provided could be helpful to advance R & D in this vital area.

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Section: Macrocyclesmentioning

confidence: 99%

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Saji

2022

The Chemical Record

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“…Supramolecular chemotherapy is of great interest owing to the dynamic nature of noncovalent interactions that contributes to the protection of drugs and controlled release at target tissues. − Among noncovalent interactions, host–guest interactions have been widely used to carry drugs that benefited from their tunable binding ability and a well-defined host–guest structure with an accurate binding ratio. ,,− For supramolecular chemotherapy systems based on host–guest interactions, the strong binding affinity of the host to drugs is essential for efficient protection of drugs from a harsh physiological environment. − However, a drug encapsulated in a stable binary host–guest complex is hard to be released by competitive guests, especially considering the low concentrations of competitive guests at target tissues. To date, some important advances have taken place to achieve controlled release of stably encapsulated drugs, ,,− but it still remains a challenge to construct a supramolecular chemotherapy system equipped with both sufficient protection and highly effective release of drugs simultaneously.…”

Section: Introductionmentioning

confidence: 99%

An Activatable Host–Guest Conjugate as a Nanocarrier for Effective Drug Release through Self-Inclusion

Wang

et al. 2021

ACS Appl. Mater. Interfaces

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There is a challenge in supramolecular chemotherapy for constructing a system equipped with both sufficient protection and high-efficiency release of drugs. To this end, a new strategy of an activatable host–guest conjugate with self-inclusion property is proposed. Based on the binding affinity gain of intramolecular host–guest self-inclusion, an activatable host–guest conjugate was designed, bearing cucurbit[7]uril as the host, an alkyl ammonium moiety as the guest, and the redox-responsive disulfide linkage. Oxaliplatin, a clinical antitumor drug, could be firmly encapsulated by the activatable host–guest conjugate to form the supramolecular drug with high stability. Moreover, oxaliplatin loaded in the activatable host–guest conjugate could be almost completely released by self-inclusion triggered by glutathione in a tumor microenvironment, thus exhibiting comparable antitumor bioactivity with naked oxaliplatin through in vitro cell experiments. It is highly anticipated that this line of research may open new horizons for programmable and on-demand supramolecular chemotherapy with high antitumor efficiency.

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“…And this supramolecular assembly is used for bioimaging in vitro with good biocompatibility . By modifying acyclic cucurbit[n]uril conjugated polymers with pro‐guest, pH‐responsive controlled release was achieved with a tunable rate based on ‘‘pro‐guest’’‐to‐guest conversion and cargo displacement …”

Section: Introductionmentioning

confidence: 99%

A New Fluorescent Sensor for Fe³⁺ Based on Glycoluril Molecular Clip

et al. 2020

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The application of fluorescent method to metal ions detection features high sensitivity, simple operation and real‐time monitoring. A 2,7‐dihydroxynaphthalene‐functionalized dimethyl glycoluril (called clip 1) was synthesized, using a relatively simple method. And it is fully characterized by 1H NMR, 13C NMR, HR‐MS and single crystal X‐ray diffraction. The recognition properties of molecular clip 1 were analyzed systematically toward several metal ions using fluorescence spectroscopy, and it was found that molecular clip 1 is selective and sensitive to Fe3+. At the same time, the clip 1 shows good anti‐interference ability when other metal ions existed. The limit detection of Fe3+ is 3×10−7M. The fluorescence of clip 1 was quenched apparently by Fe3+, which was speculated to be caused by ligand–metal charge transfer mechanism (LMCT). As a new fluorescence probe for Fe3+ ion, it may expanded the application of glycoluril molecular clips.

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Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs

Cited by 29 publications

References 35 publications

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

An Activatable Host–Guest Conjugate as a Nanocarrier for Effective Drug Release through Self-Inclusion

A New Fluorescent Sensor for Fe³⁺ Based on Glycoluril Molecular Clip

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Pro-guest and acyclic cucurbit[n]uril conjugated polymers for the controlled release of anti-tumor drugs

Cited by 29 publications

References 35 publications

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

An Activatable Host–Guest Conjugate as a Nanocarrier for Effective Drug Release through Self-Inclusion

A New Fluorescent Sensor for Fe3+ Based on Glycoluril Molecular Clip

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Product

Resources

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A New Fluorescent Sensor for Fe³⁺ Based on Glycoluril Molecular Clip