Pro‐Healing Zwitterionic Skin Sensor Enables Multi‐Indicator Distinction and Continuous Real‐Time Monitoring

Abstract

In both artificial electronic and ionic skins, the distinction of multi-stimuli response in a single sensing unit is challenging, due to unavoidable mutual signal interference. Here, a zwitterionic skin sensor system that can continuously monitor and differentiate three-stimuli-responsive information in real-time is designed. This sandwich-structured sensor system is based on a zwitterionic thermo-glucose-sensitive skin-like hydrogel at its upper and lower layers with a middle isolation elastomer layer, enabling monitoring and distinction of temperature, mechanical and glucose information without signal interference: 1) the capacitance of the upper/lower layers as glucosetemperature-insensitive is variable to measure strain; 2) the resistance of the upper hydrogel as glucose-insensitive is variable to measure strain and temperature; and 3) the resistance of the lower hydrogel can detect three indicators. Based on the skin sensor system, a smart wound dressing is developed to pro-heal chronic diabetic wounds and enable continuous realtime monitoring of three indicators-infection, swelling, and blood glucose. This work provides a new method of real-time monitoring and the distinction of multi-stimuli response in a wearable device.

“Jianbing” styling multifunctional electrospinning composite membranes for wound healing

“…The skin is a natural defense barrier that protects internal organs, and pathogens and toxins can be effectively kept out, essential for survival (Bulluck and Hausenloy, 2018;Pugliese et al, 2018;Rodrigues et al, 2019). Wound healing proceeds through three main phases: hemostasis, inflammation, proliferation, and remodeling, which are interrelated and influence each other (Agata et al, 2007;Guo and Dipietro, 2010;Guo et al, 2021;Ridiandries et al, 2018). Wound infection and excessive biological fluids (e.g., bleeding and exudate.)…”

Smart Polycationic Hydrogel Dressing for Dynamic Wound Healing

“…[6,60,61] Among them, the inflammation of the wound would be accompanied by a fever and the temperature of the inflamed wound is about 38-40 °C. [62] According to the linear responsive relationship between the relative resistance and temperature of the hydrogel in the range of 34-42 °C, the hydrogel can be applied in the dynamic monitoring of the wound healing. In summary, the SA 3 DMC 25 -Gly 80 P 7 conductive hydrogel has the potential to be used as a multifunctional sensor for dynamic monitoring of human health.…”

A Review of Recent Advances in Flexible Wearable Sensors for Wound Detection Based on Optical and Electrical Sensing

“…As for the strain, the trauma–normal detection range was 150% per free curvature and 12 k% per stretch percentage. A novelty multi-responsive hydrogel was created by combining temperature-sensitive N -isopropyl acrylamide (NIPAAm) and glucose-sensitive methylacrylamide phenyl boric acid (MPBA) on zwitterionic carboxyl betaine [ 135 ]. The sensing section could be regarded as two resistance sensors and one capacitance sensor, simultaneously responding to temperature, glucose, and strain ( Figure 5 b).…”

“…( b ) Schematic illustration of the sandwich-structured sensor. The resistance curves with temperature change from 35 to 40 °C and back to 35 °C, and those with compressive strain change from 3% to 11.95% [ 135 ]. Copyright (2021) John Wiley and Sons.…”