Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?

Henriksen, Vanessa T.; Rogers, Victoria E.; Rasmussen, G. Lynn; Trawick, Roy H.; Momberger, Nathan G.; Aguirre, Dale; Barker, Tyler

doi:10.1016/j.mehy.2013.11.020

Cited by 36 publications

(22 citation statements)

References 18 publications

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“…6 The relationship between vitamin D and inflammation has been controversial. Some hypothesize that inflammation reduces 25(OH)D concentration, [7][8][9] while others hypothesize increasing vitamin D status reduces inflammation. [10][11][12] Those who hypothesize the first explanation, that inflammation lowers 25 While it has been shown that 25(OH)D concentrations decline after major surgery, a fact used to support that inflammation lowers 25(OH)D concentration hypothesis, to our knowledge, the question of metabolic clearance has not been discussed.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and inflammation

Cannell¹,

Grant

Holick

2014

Dermato-Endocrinology

183

131

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Abbreviations: CRP, C-reactive protein; CXCL9, CXC chemokine ligand 9; E-selectin, ESR, erythrocyte sedimentation rate, F1C2, prothrombin fragment 1C2; IFG, impaired fasting glucose; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; NGAL, neutrophil gelatinase-associated lipocalin; NGT, normal glucose tolerance; ns, not stated; PAI-1, plasminogen activator inhibitor-1; sICAM-1, soluble intracellular adhesion molecule-1; sTNF-R2, soluble tumor necrosis factor a receptor type 2; TAT, thrombin antithrombin complex; TGF-b, transforming growth factor-b; TNF-a, tumor necrosis factor-a Seventeen found significantly reduced inflammatory markers, 19 did not, one was mixed and one showed adverse results. With few exceptions, studies in normal subjects, obesity, type 2 diabetics, and stable cardiovascular disease did not find significant beneficial effects. However, we found that 6 out of 7 RCTS of vitamin D 3 in highly inflammatory conditions (acute infantile congestive heart failure, multiple sclerosis, inflammatory bowel disease, cystic fibrosis, SLE, active TB and evolving myocardial infarction) found significant reductions. We found baseline and final 25(OH)D predicted RCTs with significant reduction in inflammatory markers. Vitamin D tends to modestly lower markers of inflammation in highly inflammatory conditions, when baseline 25(OH)D levels were low and when achieved 25(OH)D levels were higher. Future inquiries should: recruit subjects with low baseline 25(OH)D levels, subjects with elevated markers of inflammation, subjects with inflammatory conditions, achieve adequate final 25(OH)D levels, and use physiological doses of vitamin D. We attempted to identify all extant randomized controlled trials (RCTs) of vitamin D that used inflammatory markers as primary or secondary endpoints.

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Section: Introductionmentioning

confidence: 99%

Vitamin D and inflammation

Cannell¹,

Grant

Holick

2014

Dermato-Endocrinology

183

131

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“…3 Serum 25(OH)D is neither the most direct nor optimal measure of vitamin D absorption. Serum 25(OH)D levels are influenced by several factors that are at least partially independent of vitamin D supplementation, including genetic regulators of vitamin D binding proteins in the circulation, [4][5][6] 25(OH)D metabolism, 6,7 and the state of inflammation (increased inflammation is associated with lower 25(OH)D levels, 8,9 possibly as a result of increased urinary losses). 10 The most direct way to assess vitamin D-3 absorption is to measure the peak circulating parent vitamin D-3 level 12 hours after ingestion of the vitamin D dose.…”

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confidence: 99%

Dietary Fat Increases Vitamin D-3 Absorption

Dawson‐Hughes¹,

Harris²,

Lichtenstein³

et al. 2015

Journal of the Academy of Nutrition and Dietetics

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“…Poorer outcomes and suboptimal functional recovery after joint surgery could be due to acute reductions in 25-OHD concentration after surgery as it is reported that 25-OHD levels reduce by 40% in the first 12 h and 20% by 3 months from preoperative levels [42]. Pro-inflammatory cytokines including interferon-C and tumor necrosis factor-alpha induce 1-alphahydroxylase, which increases the conversion of 25-OHD to 1,25-OHD leading to decreased 25-OHD availability [45].…”

Section: Important Characteristics Of the Included Studiesmentioning

confidence: 99%

Vitamin D Status and Patient Outcomes after Knee or Hip Surgery: A Meta-Analysis

Zhang

Zhu²,

Dong³

et al. 2018

Ann Nutr Metab

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Background: This study evaluates the effect of vitamin D status in patient outcomes after hip or knee joint surgery. Method: Literature search was carried out in electronic databases, and study selection followed predetermined eligibility criteria. Data were extracted from relevant studies and meta-analyses of standardized mean differences between hypovitaminosis D (vitamin D deficiency or insufficiency) and euvitaminosis D in assessment scores of patient-reported outcomes were performed. Results: A total of 12 studies (2,593 patients; age 69.89 years [95% CI 68.07–71.70]; 35.95% [29.43–42.46] males) were included in the meta-analysis. The prevalence of hypovitaminosis D (vitamin D deficiency or insufficiency) was 33.18% [25.10–41.26], but the combined prevalence of deficiency and insufficiency was 46.99 [34.02–59.96]. Hospital stay was 1.09 days [–0.39 to 2.56] longer in the hypovitaminosis D group compared to the euvitaminosis D group. Preoperatively, Harris Hip Score (HHS) and Knee Society Score were significantly lower (p = 0.001 and p = 0.00001, respectively) in the hypovitaminosis D group than in the euvitaminosis D group. Postoperatively, HHS (p = 0.004) score was significantly lower in the hypovitaminosis D group than in the euvitaminosis D group. Conclusion: The prevalence of hypovitaminosis D is high in osteoarthritis patients undergoing knee or hip surgery. Vitamin D deficiency may affect the outcomes of orthopedic joint surgery. However, randomized trial/s will be required to confirm these findings.

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Pro-inflammatory cytokines mediate the decrease in serum 25(OH)D concentrations after total knee arthroplasty?

Cited by 36 publications

References 18 publications

Vitamin D and inflammation

Vitamin D and inflammation

Dietary Fat Increases Vitamin D-3 Absorption

Vitamin D Status and Patient Outcomes after Knee or Hip Surgery: A Meta-Analysis

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