Probing biofouling resistant polymer brush surfaces by atomic force microscopy based force spectroscopy

The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues

“…The most widely used microspheres for CPM is silica, as they have a low roughness, are commercially available in a variety of sizes, and their surfaces can be readily chemically modified. 31,32 The use of CPM has enabled the characterisation of protein adhesion to polymer brushes, [33][34][35] as well as bacterial adhesion. 27 In these studies, neutral and zwitterionic brushes that are particularly well solvated were shown to effectively limit adhesion of unwanted biomacromolecules and components of the bacterial membranes such as lipopolysaccharides.…”

Polystyrene-block-poly(acrylic acid) brushes grafted from silica surfaces: pH- and salt-dependent switching studies

“…Polymer brushes generally consist of a monolayer of chains that are attached at one end to a substrate, while the free-end is exposed to the surrounding medium. Over the past few decades, polymer brushes have shown to be extremely useful for many applications, such as antifouling, cell adhesion substrates, [1][2][3][4] biosensors, [5][6][7] nanocomposites, 8 stationary phases in high performance chromatography, 9-11 microreactors [12][13][14] or microactuators. 15,16 Particular properties of charged polymer or polyelectrolyte brushes have attracted the greatest attention as their degree of dissociation, conformation, and brush height can be reversibly tuned by pH and ionic strength.…”

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

“…It is well accepted and reported in the literature that the grafting polymer layer including the polymer brush structure, extending normal to the underlying substrate can provide novel and/or enhanced surface properties such as wettability, lubricity, reduced biological responses, i.e., antifouling properties, and so on. − The MPC polymers on the lens surface can provide super-hydrophilic and antifouling properties. Thus, we investigated if the MPC polymer layer would provide unique antifouling surface properties to this new contact lens in the following sections.…”