Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes

Malik, Manzoor Ahmad; Raza, Kausar; Dar, Ovas Ahmad; Amadudin,; Abid, Mohammad; Wani, Mohmmad Younus; Al‐Bogami, Abdullah S.; Hashmi, Athar Adil

doi:10.1016/j.bioorg.2019.03.080

Cited by 40 publications

(33 citation statements)

References 43 publications

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“…1). 33 The band present in Schiff base (L) at 3152 cm À1 attributed to -OH stretching vibrations was absent in complexes due to deprotonation upon complexation. 34 In complexes (C1-C4) the broad band at 3505-3510 cm À1 was attributed to n(OH) of the coordinated water present in these complexes.…”

Section: Chemistrymentioning

confidence: 99%

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

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Section: Chemistrymentioning

confidence: 99%

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

et al. 2019

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“…The results of which revealed that the ligand showed less concentration‐dependent cytotoxicity compared to the two complexes 26 and 27 . [ 62 ] The IC 50 values are given in Table 2. As shown in Figure 8, the complexes including the control showed viability ranging from 80% to 100% at a concentration of 3.13 μg ml −1 .…”

Section: Ruthenium Schiff Base Complexesmentioning

confidence: 99%

“…Viability of H1299 cells after treatment with SB, 26 and 27 . Reproduced from Malik et al 62 with permission from Elsevier…”

Section: Ruthenium Schiff Base Complexesmentioning

confidence: 99%

“…The efficacy values of RAS complexes 53-58 in the inhibition of cell viability were evaluated against a panel of human cancer cell lines (Table 3). RAS complexes 55-58 showed good killing efficacies against the (59) and N,O-and N,N-bidentate chelating ligands (60)(61)(62)(63)(64) and evaluated them for preliminary antileukemia activity. [74] The Ru (II)-arene complexes were synthesized using biologically active N-monodentate and bidentate N,N-and N,O-chelating ligand scaffolds (Scheme 4).…”

Section: Introductionmentioning

confidence: 99%

“…Reproduced from Zhang et al 58 with permission from the Centre National de la Recherche Scientifique (CNRS) and the Royal Society of Chemistry F I G U R E 8 Viability of H1299 cells after treatment with SB, 26 and 27. Reproduced from Malik et al62 with permission from ElsevierIn vitro cytotoxicity and haemolytic activities of SB, 26 and 27 very low IC 50 values, a few-fold lower than cisplatin. Compound 23 showed strong antiproliferative activity with extremely low IC 50 of 0.68 μM against A549.…”

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Recent advances in anticancer ruthenium Schiff base complexes

Parveen

2020

Applied Organom Chemis

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Nowadays in cancer treatment, both metal complexes and organic molecules are being widely used. Current years have seen a surge of interest in the application of organometallic compounds to treat cancer and other diseases. Undeniably, the unique properties of organometallic compounds, intermediate between those of classical inorganic and organic materials, provide new opportunities in the field of medicinal chemistry. Since the discovery of cisplatin, many transition metal complexes have been synthesized and assayed for anticancer activity. In recent years, ruthenium-based Schiff base complexes have emerged as promising antitumor and antimetastatic agents with potential uses in treatment of platinum-resistant tumors or as alternatives to platinum-based chemotherapy. Advantages of utilizing ruthenium complexes in drug development include reliable methods of synthesizing stable complexes; the ability to tune ligand affinities, electron transfer and substitution rates, and reduction potentials; and an increasing knowledge of the biological effects of such complexes. This great expansion of ruthenium-based Schiff base complexes is mainly due to the unique ability of the ruthenium core to permit multiple oxidation states, hence versatile electron-transfer pathways, and because of the ease of preparation with versatile and variable-denticity Schiff base ligands. This review aims to bring the reader up to date with the more recent Ru(II)/ (III)-based Schiff base complexes that have been synthesized and investigated for their cytotoxicity.

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Synthesis of 2‐Substituted Tryptamines via Cyanide‐Catalyzed Imino‐Stetter Reaction

Kim

Cheon

2020

Asian J Org Chem

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Herein, we describe the development of a twostep protocol for the synthesis of 2-substituted tryptamine derivatives from 2-aminocinnamyl nitriles and aldehydes. The cyanide-catalyzed imino-Stetter reaction of 2-aminocinnamyl nitriles and aldehydes provided 2-substituted indole-3-acetonitrile derivatives. Subsequent reduction of the nitrile group afforded the desired 2-substituted tryptamine derivatives. The utility of this protocol was demonstrated in the synthesis of a potential inhibitor of 15lipoxygenase. Furthermore, the resulting 2-substituted indole-3-acetonitriles were converted to several 2,3-disubstituted indole derivatives upon transformation of the nitrile group into other functional groups.

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Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes

Cited by 40 publications

References 43 publications

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

New transition metal complexes with a pendent indole ring: insights into the antifungal activity and mode of action

Recent advances in anticancer ruthenium Schiff base complexes

Synthesis of 2‐Substituted Tryptamines via Cyanide‐Catalyzed Imino‐Stetter Reaction

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