Probiotic Lactobacillus plantarum P8 alleviated stress and anxiety while enhancing memory and cognition in stressed adults: A randomised, double-blind, placebo-controlled study

Lew, Lee-Ching; Hor, Yan-Yan; Yusoff, Nur Asmaa’ A.; Choi, Sy Bing; Yusoff, Muhamad Saiful Bahri; Roslan, Nurhanis Syazni; Ahmad, Anisa; Mohammad, Jamilah Al-Muhammady; Abdullah, Mohammad Farris Iman Leong Bin; Zakaria, Norashikin; Wahid, Nabsiah Abdul; Sun, Zhihong; Kwok, Lai‐Yu; Zhang, Heping; Liong, Min‐Tze

doi:10.1016/j.clnu.2018.09.010

Cited by 196 publications

(168 citation statements)

References 26 publications

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“…Lactobacillus plantarum supplementation decreased depressivelike symptoms in chronic-stressed mice (Liu Y.W. et al, 2016;Dhaliwal et al, 2018) and stressed adults with mild depression (Lew et al, 2018), though the latter study did not reach statistical significance. Following L. plantarum intake, reduction in plasma corticosterone levels and inflammation were seen in mice with reduced depressive-like behaviors (Liu Y.W.…”

Section: Lactobacillus Plantarummentioning

confidence: 95%

“…Attention, memory and learning behaviors in humans are assessed by cognitive tests, such as the Stroop, verbal-learning and digit-symbol tests. Improvements in these tests have been shown with the intake of (1) L. helveticus Ohsawa et al, 2018) and B. longum (Allen et al, 2016) in healthy adults; (2) L. plantarum in MDD patients (Rudzki et al, 2019) and stressed adults with mild depression (Lew et al, 2018); and (3) B. breve in elderly with mild cognitive impairment . Thus, some probiotics appear to improve cognition regardless of depression.…”

Section: Heterogeneity Of Depressionmentioning

confidence: 98%

“…et al, 2016;Liu Y.W. et al, 2016;Dhaliwal et al, 2018;Lew et al, 2018), B. longum (Bercik et al, 2010(Bercik et al, , 2011Savignac et al, 2014;Allen et al, 2016) and B. breve (Savignac et al, 2014;Okubo et al, 2019;Tian et al, 2019). Moreover, MSPs intake often decreased depression and anxiety simultaneously in randomized controlled trials (Mohammadi et al, 2016;Kouchaki et al, 2017;Jamilian et al, 2018;Raygan et al, 2018;Ostadmohammadi et al, 2019;Salami et al, 2019).…”

Section: Heterogeneity Of Depressionmentioning

confidence: 99%

“…Butyrate can enter IECs through cholesterol-rich microdomains and/or monocarboxylate transporter 1 protein Goncalves et al, 2011;Nedjadi et al, 2014), and promote synthesis and assembly of tight junction proteins of IECs (Bordin et al, 2004;Ohata et al, 2005;Peng et al, 2009;Yan and Ajuwon, 2017). Butyrate also has anti-inflammatory properties; for instance, butyrate inhibited proinflammatory activities of IECs in vitro (Elce et al, 2017) and interacted with IECs to regulate host T cell responses (Lew et al, 2018;Xu et al, 2018). Butyrate may also diffuse into the systemic circulation to exert anti-inflammatory effects on various organs and tissues, including the brain (McNabney and Henagan, 2017;Matt et al, 2018).…”

Section: Butyrate Intestinal Barrier and Bdnf Expressionmentioning

confidence: 99%

“…However, MSPs may have higher potency in humans. In MDD patients, SSP (L. plantarum) did not reduce depression but improved cognition (Lew et al, 2018), whereas MSPs had repeatedly shown antidepressive efficacy (Akkasheh et al, 2016;Bambling et al, 2017;Ghorbani et al, 2018;Kazemi et al, 2019). MSPs often gave better therapeutic efficacy compared to that of SSPs in gut-related disorders and pathogen infections, which could be explained by an overall higher dosage (Chapman et al, 2011(Chapman et al, , 2012.…”

Section: Single-species and Multi-species Probioticmentioning

confidence: 99%

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Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

et al. 2020

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The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut microbiota and the brain. This communication process involves the endocrine, immune and neurotransmitters systems. Dysfunction of these systems, along with the presence of gut dysbiosis, have been detected among clinically depressed patients. This implicates the involvement of a maladaptive MGB axis in the pathophysiology of depression. Depression refers to symptoms that characterize major depressive disorder (MDD), a mood disorder with a disease burden that rivals that of heart diseases. The use of probiotics to treat depression has gained attention in recent years, as evidenced by increasing numbers of animal and human studies that have supported the antidepressive efficacy of probiotics. Physiological changes observed in these studies allow for the elucidation of probiotics antidepressive mechanisms, which ultimately aim to restore proper functioning of the MGB axis. However, the understanding of mechanisms does not yet complete the endeavor in applying probiotics to treat MDD. Other challenges remain which include the heterogeneous nature of both the gut microbiota composition and depressive symptoms in the clinical setting. Nevertheless, probiotics offer some advantages over standard pharmaceutical antidepressants, in terms of residual symptoms, side effects and stigma involved. This review outlines antidepressive mechanisms of probiotics based on the currently available literature and discusses therapeutic potentials of probiotics for depression.

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Section: Lactobacillus Plantarummentioning

confidence: 95%