Probiotic Therapy Reduces Periodontal Tissue Destruction and Improves the Intestinal Morphology in Rats With Ligature‐Induced Periodontitis

Messora, Michel Reis; Oliveira, Luana Farias de; Foureaux, Renata de Carvalho; Taba, Mário; Zangerônimo, Márcio Gilberto; Furlaneto, Flávia Aparecida Chaves; Pereira, Luciano José

doi:10.1902/jop.2013.120644

Cited by 97 publications

(145 citation statements)

References 46 publications

(102 reference statements)

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“…A cotton ligature was placed around their right mandibular first molars, as previously described [18]. …”

Section: Methodsmentioning

confidence: 99%

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Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Ricoldi¹,

Furlaneto²,

Oliveira³

et al. 2017

PLoS ONE

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Lactobacillus probiotics have been investigated in periodontitis. However, the effects of the genus Bifidobacterium on periodontitis are hardly known. This study evaluated the effects of the probiotic (PROB) Bifidobacterium animalis subsp. lactis (B. lactis) HN019 as an adjunct to scaling and root planing (SRP) in rats with experimental periodontitis (EP). At baseline, 32 rats were assigned to 4 groups: C (control), PROB, EP-SRP and EP-SRP-PROB. In groups EP-SRP and EP-SRP-PROB, the mandibular first molars of the animals received a ligature. At day 14, the ligatures were removed and SRP was performed. Animals of groups PROB and EP-SRP-PROB were orally administered with 10 mL/day of 109 colony forming units of B. lactis HN019 for 15 days, starting at day 14. Animals were euthanized at day 29. Histomorphometric, microtomographic and immunohistochemical analyses were performed. Microbiological effects of B. lactis on biofilm were also evaluated. Data were statistically analyzed (ANOVA, Tukey; Kruskal-Wallis, Dunn’s; Two-tailed t-test; p<0.05). Group EP-SRP-PROB presented reduced alveolar bone resorption and attachment loss when compared with Group EP-SRP (p<0.05). Group EP-SRP-PROB showed significantly fewer osteoclasts, increased expression of anti-inflammatory cytokines and reduced expression of proinflammatory cytokines compared with Group EP-SRP (p<0.05). B. lactis promoted a higher ratio between aerobic and anaerobic bacteria in biofilm samples (p<0.05). B. lactis HN019 may have a role in the treatment of EP in rats, as an adjunct to SRP.

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“…A cotton ligature was placed around their right mandibular first molars, as previously described [18]. …”

Section: Methodsmentioning

confidence: 99%

“…After routine laboratorial processing [18], two sections representing the most central buccal-lingual portion in the furcation area of right mandibular first molars were selected for histopathological and histometric analyses. The histopathological analysis was performed by a certified histologist (E.E.)…”

Section: Methodsmentioning

confidence: 99%

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Ricoldi¹,

Furlaneto²,

Oliveira³

et al. 2017

PLoS ONE

Self Cite

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“…Using this model, mice with periodontitis that were treated with Lactobacillus brevis CD2 displayed decreased bone loss and lower expression of pro-inflammatory cytokines such as tumor necrosis factor, interleukin-1β and -17A (Fig 5). Similar studies in a rat model of periodontal disease indicate that probiotics (Bacillus subtilus and Saccharomyces cerevisiae ) can decrease bone resorption, increased bone density, and decreased inflammation [99, 100]; dysbiosis was also prevented by probiotic treatment [99]. …”

Section: ) Mechanisms Of Probiotic Prevention Of Bone Pathophysiologymentioning

confidence: 99%

Probiotics in Gut-Bone Signaling

Schepper

Irwin

Kang

et al. 2017

Advances in Experimental Medicine and Biology

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The intestinal environment is linked to an array of conditions and diseases, including osteoporosis. Human and animal studies indicate that probiotics can benefit intestinal health and may provide a useful therapeutic to prevent and/or treat bone loss. Probiotics are defined as live microorganisms that when administered in adequate amounts will confer a health benefit on the host. In this review, we will focus on 1) probiotics (definition, history, nomenclature, types), 2) the effects of probiotics on bone health and 3) mechanisms of probiotic prevention of bone pathologies.

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“…Hence, W. cibaria isolates possess the ability to inhibit biofilm formation 11 . Probiotic Bacillus Subtilis, reduced attachment loss and alveolar bone loss in rats with ligature induced periodontitis and also it protected the small intestine from reactive changes induced by LIP 50 . Lactobacillus reuteri-containing probiotic lozenges used in chronic periodontitis patients caused significant pocket depth reduction, attachment gain in moderate and deep pockets and reduction in Porphyromonas gingivalis 51 .…”

Section: Periodontal Diseasementioning

confidence: 88%

Probiotikler ve Diş Hekimliğinde Kullanımı

Shanbhag¹

2014

Arşiv Kaynak Tarama Dergisi

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Probiotic Therapy Reduces Periodontal Tissue Destruction and Improves the Intestinal Morphology in Rats With Ligature‐Induced Periodontitis

Abstract: It can be concluded that PROB supplementation 1) reduces AL and alveolar bone loss in rats with LIP and 2) can protect the small intestine from reactive changes induced by LIP.

Cited by 97 publications

References 46 publications

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats

Probiotics in Gut-Bone Signaling

Probiotikler ve Diş Hekimliğinde Kullanımı

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