Probiotics and Psychobiotics: the Role of Microbial Neurochemicals

Oleskin, Alexander V.; Shenderov, Boris A.

doi:10.1007/s12602-019-09583-0

Cited by 67 publications

(55 citation statements)

References 94 publications

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“…Also, the association between indole-3-propionic acid and MS disease activity is particularly interesting, since this molecule is one of the Trp-derived metabolites produced by the microbiota, called post-biotics (33,34), that have been deeply investigated in recent years because of their presence in peripheral tissues and their ability to bind xenobiotic receptors. Indole-3-propionic acid is now known to contribute to changes in body weight gain on a tryptophan-rich diet (35).…”

Section: Discussionmentioning

confidence: 99%

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

et al. 2020

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Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that is associated with demyelination and neuronal loss. Over recent years, the immunological and neuronal effects of tryptophan (Trp) metabolites have been largely investigated, leading to the hypothesis that these compounds and the related enzymes are possibly involved in the pathophysiology of MS. Specifically, the kynurenine pathway of Trp metabolism is responsible for the synthesis of intermediate products with potential immunological and neuronal effects. More recently, Trp metabolites, originating also from the host microbiome, have been identified in MS, and it has been shown that they are differently regulated in MS patients. Here, we sought to discuss whether, in MS patients, a specific urinary signature of host/microbiome Trp metabolism can be potentially identified so as to select novel biomarkers and guide toward the identification of specific metabolic pathways as drug targets in MS.

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Section: Discussionmentioning

confidence: 99%

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

et al. 2020

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“…In neurology and psychiatry, there is growing evidence of a relationship between the gut microbiota and diseases such as depression, anxiety, and even autism. Probiotic strains are being developed and specifically studied for this purpose, and they even get a special name: psychobiotics (3,(214)(215)(216)(217) .…”

Section: Gynecological Diseases Atopy Depression Anxiety and Autismmentioning

confidence: 99%

Gut Microbiota, Prebiotics, Probiotics, and Synbiotics in Gastrointestinal and Liver Diseases: Proceedings of a Joint Meeting of the Brazilian Society of Hepatology (Sbh), Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (Nbehpm), and Brazilian Federation of Gastroenterology (Fbg)

Schiavon¹,

Oliveira

Álvares‐da‐Silva

et al. 2020

Arq. Gastroenterol.

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Over the last years, there is growing evidence that microorganisms are involved in the maintenance of our health and are related to various diseases, both intestinal and extraintestinal. Changes in the gut microbiota appears to be a key element in the pathogenesis of hepatic and gastrointestinal disorders, including non-alcoholic fatty liver disease, alcoholic liver disease, liver cirrhosis, inflammatory bowel disease, irritable bowel syndrome, and Clostridium difficile - associated diarrhea. In 2019, the Brazilian Society of Hepatology (SBH) in cooperation with the Brazilian Nucleus for the Study of Helicobacter Pylori and Microbiota (NBEHPM), and Brazilian Federation of Gastroenterology (FBG) sponsored a joint meeting on gut microbiota and the use of prebiotics, probiotics, and synbiotics in gastrointestinal and liver diseases. This paper summarizes the proceedings of the aforementioned meeting. It is intended to provide practical information about this topic, addressing the latest discoveries and indicating areas for future studies.

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“…Very recently it has been shown that the BAs produced by commensal gut microbes could be responsible for certain intoxications and pathologies (depression, anxiety, psychosis) due to the close relationship established between the gut flora and brain (microbiota‐gut‐brain axis; Oleskin and Shenderov, ; Sudo, ). Thus, the oral administration of bacterial cultures able to assimilate BAs could avoid the risk of the neurological problems caused by the uncontrolled liberation of these amines in the gut.…”

Section: Biotechnological Applications and Future Outlookmentioning

confidence: 99%

“…They also protect the bacteria against radiations and oxidative stress and participate in biofilm formation, in the development of mechanisms of antibiotic resistance and in pathogenesis (Maeda et al, 2006;Patel et al, 2006;Kwon and Lu, 2007;Shah and Swiatlo, 2008;Williams et al, 2010). It has been reported recently that certain amines generated by commensal gut microbes are involved in molecular signalling and are related to different syndromes (depression, anxiety, psychosis), highlighting the importance of the 'microbial-gut-brain' axis (Oleskin and Shenderov, 2019;Ruiz-Capillas and Herrero, 2019;Sudo, 2019).…”

Section: Introductionmentioning

confidence: 99%

Catabolism of biogenic amines in Pseudomonas species

Luengo

Olivera

2020

Environmental Microbiology

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Summary Biogenic amines (BAs; 2‐phenylethylamine, tyramine, dopamine, epinephrine, norepinephrine, octopamine, histamine, tryptamine, serotonin, agmatine, cadaverine, putrescine, spermidine, spermine and certain aliphatic amines) are widely distributed organic molecules that play basic physiological functions in animals, plants and microorganisms. Pseudomonas species can grow in media containing different BAs as carbon and energy sources, a reason why these bacteria are excellent models for studying such catabolic pathways. In this review, we analyse most of the routes used by different species of Pseudomonas (P. putida, P. aeruginosa, P. entomophila and P. fluorescens) to degrade BAs. Analysis of these pathways has led to the identification of a huge number of genes, catabolic enzymes, transport systems and regulators, as well as to understanding of their hierarchy and functional evolution. Knowledge of these pathways has allowed the design and collection of genetically manipulated microbes useful for eliminating BAs from different sources, highlighting the biotechnological applications of these studies.

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Probiotics and Psychobiotics: the Role of Microbial Neurochemicals

Cited by 67 publications

References 94 publications

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis

Catabolism of biogenic amines in Pseudomonas species

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