Probiotics and synbiotics show clinical efficacy in treating gestational diabetes mellitus: A meta-analysis

Yu, Hao; Zhou, Lushan; Ding, Caifei; Wu, Ji; Chen, Xiaoling; Ng, Derry Minyao; Wang, Hezhenrong; Zhang, Yingying; Shi, Nian‐Qing

doi:10.1016/j.pcd.2021.08.005

Cited by 29 publications

(22 citation statements)

References 54 publications

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“…24 A meta-analysis demonstrated that probiotic/symbiotic-based interventions positively impacted fetal macrosomia and newborn weight, and improved the glucose and lipid metabolism in diet-controlled GDM patients. 25 The growth of Lactobacilli and Bifidobacteria is supported by the β-glucans both in vivo and in vitro , with a concurrent marked increase in SCFAs (acetic, butyric and propionic acids). 26 SCFAs regulate energy expenditure and energy supply through signaling pathways of G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs) in the intestine, liver, and pancreas, and then improve the glucose homestasis.…”

Section: Discussionmentioning

confidence: 99%

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Yang,

Cai,

Zhu

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Yang,

Cai,

Zhu

et al. 2023

Food Funct.

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“…The presence of obesity has been associated with low-grade inflammation in the body ( 33 ), thus the beneficial effects of probiotics on child’s weight may be due to their anti-inflammatory effects during pregnancy ( 21 , 34 ). The inflammatory markers can cross the placenta and affect the development of metabolic pathways in the fetus that could later lead to the development of various diseases, such as obesity ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

Saros

Vahlberg

Koivuniemi

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Objectives: To evaluate whether a fish oil and/or probiotics intervention in pregnant women with overweight or obesity would influence the tendency of their 24-month-old children to become overweight and alter their body fat percentage. Methods: Women (n = 439) were double-blindly randomized into 4 intervention groups: fish oil+placebo, probiotics+placebo, probiotics+fish oil, and placebo+placebo (fish oil: 1.9 g docosahexaenoic acid and 0.22 g eicosapentaenoic acid, probiotics: Lacticaseibacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 10 10 colony-forming units each). The intervention lasted from early pregnancy until 6 months postpartum. Children's (n = 330) growth data (height, weight, head circumference), a secondary outcome of the trial, were evaluated at birth, 3, 6, 12, and 24 months of age and compared to Finnish growth charts. Body fat percentage was measured with air displacement plethysmography (24 months). Logistic regression and general linear models were used to analyze the data. Results: Probiotics+placebo [weight-for-height% adj. Odds ratio (OR) = 0.36, 95% confidence interval (CI) = 0.14-0.95] and probiotics+fish oil [weight-for-age standard deviation score (SD-score) adj. OR = 0.22, 95% CI = 0.07-0.71] associated with lower overweight odds in 24-monthold children compared to placebo+placebo. Results remained essentially the same, when probiotics' main effect (combined probiotics+placebo and probiotics+fish oil) was estimated; that is, lower overweight odds (weightfor-height% adj. OR = 0.48, 95% CI = 0.25-0.95 and weight-for-age SDscore adj. OR = 0.42, 95% CI = 0.20-0.88) compared to non-probiotics. No fish oil main effect (combined fish oil+placebo and probiotics+fish oil) was seen. The intervention did not influence body fat percentage. Conclusions: The administration of probiotics solely and in combination with fish oil during pregnancy to women with overweight or obesity lowered the overweight odds of their 24-month-old children.

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“…Similarly, the use of synbiotics have also shown notable benefits on the clinical management of GDM. According to a meta-analysis conducted by Zhou et al [ 29 ], this type of intervention has demonstrated significant improvements on glucose and lipid metabolism, as well as having an anti-inflammatory and antioxidant effect on diet controlled GDM patients, reducing the risk of fetal hyperbilirubinemia, fetal macrosomia, and limiting newborn weight. Similarly, a systematic review and meta-analysis also demonstrated that the use of synbiotics ameliorated insulin resistance in GDM women [ 30 ].…”

Section: Prebiotics For Pregnancy Complicationsmentioning

confidence: 99%

The Use of Prebiotics from Pregnancy and Its Complications: Health for Mother and Offspring—A Narrative Review

García-Montero

Fraile-Martínez

Rodriguez-Martín

et al. 2023

Foods

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Pregnancy involves a metabolic reprogramming that includes changes in the gut microbiota composition in women. Evidence shows that maternal dysbiosis is linked to neonatal dysbiosis, and this factor can determine health status in adulthood. Although there is little literature available on this topic, high heterogeneity is a limitation when examining nutritional interventions. Information has been gathered to contrast the benefits of prebiotic usage, specifically in pregnancy, in its possible complications and in newborns’ gut microbiota development. The objective pursued in this brief narrative review is to provide a clear summary of relevant content when searching with regard to the use of prebiotics in pregnancy, the effects in prenatal and postnatal periods, and to help in clinical decision-making in pregnancy management and lactation. A search has found that the nutritional status of the pregnant mother is key for the earliest microbial colonization in newborns, and thus intervention programs from pregnancy could assure better outcomes in both the mother and offspring. In this sense, prebiotics (administered to mothers who breastfeed or provided in formula milk) are feasible and cost-effective elements that can prevent allergies, colic, and other maladies in newborns.

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Probiotics and synbiotics show clinical efficacy in treating gestational diabetes mellitus: A meta-analysis

Cited by 29 publications

References 54 publications

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Oat β-glucan supplementation pre- and during pregnancy alleviates fetal intestinal immunity development damaged by gestational diabetes in rats

Fish Oil And/Or Probiotics Intervention in Overweight/Obese Pregnant Women and Overweight Risk in 24-Month-Old Children

The Use of Prebiotics from Pregnancy and Its Complications: Health for Mother and Offspring—A Narrative Review

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