Probiotics and the envisaged role in treating human infertility

Younis, Nagham; Mahasneh, Adel M.

doi:10.1186/s43043-020-00039-y

Cited by 15 publications

(7 citation statements)

References 71 publications

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“…Lactobacilli are the most studied probiotic bacteria, and they show several mechanisms in protecting the vaginal environment, including production of lactic acid that deters pathogens by lowering the pH and yielding an acidic environment to the cervico-vaginal mucus [ 27 ]; production of bacteriocins, which are antimicrobial peptides and proteins that protect against microbial invasion; and enhancement of immunomodulation by producing H 2 O 2 and stimulating anti-inflammatory action [ 28 ]. In a recent review article, Younis et al drew attention to the importance of further exploring in future clinical research the role of probiotics in managing infertility [ 29 ]. Bhandari et al demonstrated that Lactobacillis plantarum works to competitively exclude sperm-agglutinating Escherichia coli ( E. coli ) bacteria.…”

Section: Infertilitymentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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Section: Infertilitymentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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“…The manipulation of the microbiota existing in the reproductive tract of both males and females can be an effective tool to control many reproductive diseases and associated infertility. Reproductive outcomes in both humans [39,40] and animal models [14,41] may be improved by decreasing the proportion of dysbiotic microorganisms and microbial pathogens in the reproductive tract and increasing the proportion of symbiotic microorganisms. According to this concept, the use of antibiotics and the use of probiotics are basically two approaches that may be used to manage reproductive tract microbiota.…”

Section: Manipulation Of Reproductive Tract Microbiotamentioning

confidence: 99%

“…These studies have supported the use of probiotics-based therapy as a potential tool to enhance reproductive efficiency and to tackle infertility in males. Probiotics have been demonstrated to improve spermatogenesis, epididymal sperm count, and normal sperm percentage and to reduce the percentage of sperm morphological abnormalities and DNA damage in mammalian species, including humans [39].…”

Section: Men's Fertilitymentioning

confidence: 99%

“…Infertility related to age [87], obesity [54], prostate diseases [34], and psychological and environmental stresses [84], as well as idiopathic infertility [8], can be improved by administering probiotics-based therapies either alone [8,85] or as a co-therapy [9]. In fact, regardless the different causes, male infertility seems to be concomitant to the inadequacy of testosterone levels and other sex hormones and the increase in inflammatory responses and oxidative stress [39,84]. As reported in many studies, probiotics can improve the fertility of males mainly by improving testosterone levels, attenuating inflammatory responses, and reversing the adverse effects of oxidative stress [87].…”

Section: Studies On Menmentioning

confidence: 99%

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The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

Hashem

González-Bulnes

2022

Nutrients

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Reproductive tract dysbiosis, due to the action of pathogens and/or unhealthy lifestyle, has been related to many reproductive diseases and disorders in mammalian species. Classically, such a problem has been confronted by the administration of antibiotics. Despite their effectiveness for controlling disease, treatments with antibiotics may negatively affect the fertility of males and females and, mainly, may induce antibiotic resistance. Accordingly, safer alternatives for maintaining reproductive system eubiosis, such as probiotics, are required. The present review summarizes the current knowledge on the biodiversity of the microbiota at the reproductive tract, possible changes in the case of dysbiosis, and their relationships with adequate reproductive health and functioning in both females and males. Afterwards, mechanisms of action and benefits of different probiotics are weighed since the biological activities of probiotics may provide a promising alternative to antibiotics for maintaining and restoring reproductive eubiosis and function. However, at present, it is still necessary for further research to focus on: (a) identifying mechanisms by which probiotics can affect reproductive processes; (b) the safety of probiotics to the host, specifically when consumed during sensitive reproductive windows such as pregnancy; and (c) the hazards instructions and regulatory rules required for marketing these biological-based therapies with sufficient safety. Thus, in this review, to draw a comprehensive overview with a relatively low number of clinical studies in this field, we showed the findings of studies performed either on human or animal models. This review strategy may help provide concrete facts on the eligible probiotic strains, probiotics colonization and transfer route, and prophylactic and/or therapeutic effects of different probiotic strains.

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“…plays a crucial role in avoiding the invasion of pathogenic bacteria and dysbiosis of native microbiota [ 6 ]. These lactic acid bacteria's influence on fertility and their role in promoting fecundity could be discussed from two main perspectives: first, male fertility and the potential antioxidant impact of lactic acid bacteria on sperm parameters, testicular histopathology, and testosterone level and second, female fertility and the effect of lactic acid bacteria on maintaining the bacterial balance in the vagina, treatment of bacterial vaginosis, and the subsequent effect on amelioration of bacterial vaginosis [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Lactic Acid Bacteria on Animal Reproduction Function

Mahendra

Dadi

Kamaludeen

et al. 2022

Veterinary Medicine International

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Considering the importance of a healthy uterus to the success of breeding, the beneficial effects of lactic acid bacteria on animal reproduction function are of particular interest. In recent decades, infertility has become a widespread issue, with microbiological variables playing a significant role. According to reports, dysbiosis of the vaginal microbiota is connected with infertility; however, the effect of the normal vaginal microbiota on infertility is unknown. In addition, lactic acid bacteria dominate the reproductive system. According to evidence, vaginal lactic acid bacteria play a crucial role in limiting the invasion of pathogenic bacteria by triggering anti-inflammatory chemicals through IL-8, IL-1, and IL-6; immunological responses through inhibition of the adherence of other microorganisms, production of inhibiting substances, and stimulation of mucus production; and also reproductive hormones by increased testosterone hormone release, enhanced the levels of luteinizing hormone, follicle stimulating hormone, the amount of prostaglandin E (2), and prostaglandin F2 alpha. The objective of this study was to compare the advantages of lactic acid bacteria in animal reproduction based on the most recent literature. The administration of a single strain or numerous strains of lactic acid bacteria has a favourable impact on steroidogenesis, gametogenesis, and animal fertility.

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Probiotics and the envisaged role in treating human infertility

Cited by 15 publications

References 71 publications

Nutrition in Gynecological Diseases: Current Perspectives

Nutrition in Gynecological Diseases: Current Perspectives

The Use of Probiotics for Management and Improvement of Reproductive Eubiosis and Function

Beneficial Effects of Lactic Acid Bacteria on Animal Reproduction Function

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