Probiotics for induction of remission in ulcerative colitis

Kaur, Lakhbir; Gordon, Morris; Baines, Patricia Anne; Iheozor‐Ejiofor, Zipporah; Sinopoulou, Vassiliki; Akobeng, Anthony K

doi:10.1002/14651858.cd005573.pub3

Cited by 83 publications

(79 citation statements)

References 44 publications

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“…The methods and preparation of probiotic supplements in the included studies were different and it might have an influence on pooling the results. The response to probiotics intake might also have been influenced by a number of within-study factors, such as antibiotic use [ 46 ] and corticosteroid therapy [ 47 ]; moreover, the serum levels of hs-CRP is influenced by corticosteroid drugs [ 48 ]. Anyway, none of the seven included studies adjusted the mentioned confounders.…”

Section: Discussionmentioning

confidence: 99%

Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Bohlouli

Namjoo

Borzoo-Isfahani

et al. 2021

Heliyon

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Section: Discussionmentioning

confidence: 99%

Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Bohlouli

Namjoo

Borzoo-Isfahani

et al. 2021

Heliyon

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“…This has generated interest in how probiotics may be harnessed to mediate the mucosal inflammation of IBD [ 22 ]. Different strains of probiotics have shown promise in the treatment of both active disease and the maintenance of disease remission in IBD [ 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…In active IBD, there are additional efficacy differences found in UC and CD. Though there have been numerous studies investigating probiotic usage and outcomes in UC, the diversity of probiotic usage and variance in study design have limited the conclusions that can be drawn from meta-analyses [ 31 , 32 ]. This being said, there have been studies showing the therapeutic benefit of probiotics either alone or in conjunction with standard-of-care therapy in UC [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases

et al. 2020

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The microbiome is an important contributor to a variety of fundamental aspects of human health, including host metabolism, infection, and the immune response. Gut dysbiosis has been identified as a contributor to the errant immune response in a variety of immune-mediated inflammatory diseases (IMIDs), such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), and psoriatic disease (psoriasis and psoriatic arthritis). Given this, probiotics and prebiotics have been investigated as therapeutic options in these disease states. In our review, we highlight the current evidence on prebiotics and probiotics as well as other supplements (such as fish oils, vitamin D, and curcumin) as therapies for IBD. Recommendations, however, regarding the specific use of such supplements in IBD have been lacking, particularly from professional societies, often due to study limitations related to small sample sizes and design heterogeneity. Hence, we additionally examine the literature on the use of prebiotics, probiotics, and other supplements in related IMIDs, namely RA and psoriasis/psoriatic arthritis, as these diseases share many approved therapeutic options with IBD. Based on these combined findings, we offer additional evidence that may help guide clinicians in their treatment of patients with IBD (and other IMIDs) and provide recommendations on potential next steps in therapeutic research in this area.

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“…Although probiotics have been recommended for adjunctive therapy for inducing and maintaining a remission of pouchitis and UC ( 57 , 58 ), the clinical efficacy of probiotics for inducing and maintaining a remission of UC is limited. Results from a recent review analyzing 14 randomized controlled trials including 865 participants show low-certainty evidence that probiotics induce clinical remission in active UC patients when compared with a placebo and little or no difference when compared with 5-ASA ( 71 ). Based on limited information, this review reported that the combination of probiotics and 5-ASA may slightly improve the induction of remission compared with 5-ASA alone in patients with mild, but not severe, disease ( 71 ).…”

Section: Intestinal Inflammatory Diseases and Cancermentioning

confidence: 99%

“…Results from a recent review analyzing 14 randomized controlled trials including 865 participants show low-certainty evidence that probiotics induce clinical remission in active UC patients when compared with a placebo and little or no difference when compared with 5-ASA ( 71 ). Based on limited information, this review reported that the combination of probiotics and 5-ASA may slightly improve the induction of remission compared with 5-ASA alone in patients with mild, but not severe, disease ( 71 ). In fact, the combination of probiotics with traditional IBD therapy is the most widely investigated treatment for UC patients in current clinical trials.…”

Section: Intestinal Inflammatory Diseases and Cancermentioning

confidence: 99%

Probiotics and Probiotic-Derived Functional Factors—Mechanistic Insights Into Applications for Intestinal Homeostasis

2020

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Advances in our understanding of the contribution of the gut microbiota to human health and the correlation of dysbiosis with diseases, including chronic intestinal conditions such as inflammatory bowel disease (IBD), have driven mechanistic investigations of probiotics in intestinal homeostasis and potential clinical applications. Probiotics have been shown to promote intestinal health by maintaining and restoring epithelial function, ensuring mucosal immune homeostasis, and inhibiting pathogenic bacteria. Recent findings reveal an approach for defining previously unrecognized probiotic-derived soluble factors as potential mechanisms of probiotic action. This review focuses on the impact of probiotics and probiotic-derived functional factors, including probiotic products and metabolites by probiotics, on the cellular responses and signaling pathways involved in maintaining intestinal homeostasis. Although there is limited information regarding the translation of probiotic treatment outcomes from in vitro and animal studies to clinical applications, potential approaches for increasing the clinical efficacy of probiotics for IBD, such as those based on probiotic-derived factors, are highlighted in this review. In this era of precision medicine and targeted therapies, more basic, preclinical, and clinical evidence is needed to clarify the efficacy of probiotics in maintaining intestinal health and preventing and treating disease.

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Probiotics for induction of remission in ulcerative colitis

Cited by 83 publications

References 44 publications

Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Efficacy of Dietary Supplements in Inflammatory Bowel Disease and Related Autoimmune Diseases

Probiotics and Probiotic-Derived Functional Factors—Mechanistic Insights Into Applications for Intestinal Homeostasis

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