Probiotics in inflammatory bowel disease: a critical review

Tamboli, Cyrus; Caucheteux, Christel; Cortot, Antoine; Colombel, Jean–Frédéric; Desreumaux, Pierre

doi:10.1016/s1521-6918(03)00076-3

Cited by 65 publications

(40 citation statements)

References 55 publications

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“…The diversity of probiotic strains used in various dosages and regimens may contribute to this ambiguity and makes a comparison of their efficacies in treating disease difficult (37).…”

Section: Discussionmentioning

confidence: 99%

“…Probiotics have been investigated intensively with inflammatory bowel disease and pouchitis, in which it was shown previously that such a therapy has a beneficial effect on gut barrier integrity and can ameliorate inflammatory responses (27)(28)(29)(30). Although some of these studies show a beneficial effect of probiotic therapy on inflammation and bacterial translocation, there is limited documentation of the efficacy of these agents in properly designed controlled trials, which complicates the practical application of probiotics in a clinical setting (16,35,37). Furthermore, the underlying mode of action is not yet fully understood, and it remains to be determined whether the described effects are limited to inflammatory bowel disease or can also be applied to other disease states in which gut barrier integrity is compromised.…”

mentioning

confidence: 99%

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Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock

Luyer¹,

Buurman²,

Hadfoune³

et al. 2005

Infect Immun

101

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Probiotic therapy modulates the composition of the intestinal flora and inhibits the inflammatory response. These properties may be of benefit in the preservation of gut barrier integrity after injury or stress. In this study, we examined the effect of two Lactobacillus strains selected for their pathogen exclusion properties on intestinal barrier integrity following hemorrhagic shock. Additionally, the responsiveness of the macrophage cell line RAW 264.7 to combined exposure to Lactobacillus DNA or oligodeoxynucleotides containing CpG motifs (CpG-ODN) and endotoxin was assessed by measuring tumor necrosis factor alpha (TNF-␣) release. Rats were administered lactobacilli (5 ؋ 10 9 CFU) or vehicle for 7 days and were subjected subsequently to hemorrhagic shock by withdrawal of 2.1 ml blood/100 g tissue. Levels of plasma endotoxin, bacterial translocation to distant organs, and filamentous actin (F-actin) in the ileum were determined 24 h later. Rats treated with Lactobacillus rhamnosus showed reduced levels of plasma endotoxin (8 ؎ 2 pg/ml versus 24 ؎ 4 pg/ml; P ‫؍‬ 0.01), bacterial translocation (2 CFU/gram versus 369 CFU/gram; P < 0.01), and disruption of F-actin distribution following hemorrhagic shock compared with nontreated control rats. In contrast, pretreatment with Lactobacillus fermentum had no substantial effect on gut barrier integrity. Interestingly, DNA preparations from both lactobacilli reduced endotoxin-induced TNF-␣ release dose dependently, whereas CpG-ODN increased TNF-␣ release. In conclusion, the pathogen exclusion properties of both Lactobacillus strains and the reduction of endotoxin-induced inflammation by their DNA in vitro are not prerequisites for a beneficial effect of probiotic therapy on gut barrier function following hemorrhagic shock. Although pretreatment with Lactobacillus spp. may be useful to preserve gut barrier integrity following severe hypotension, a thorough assessment of specific strains seems to be essential.

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“…The diversity of probiotic strains used in various dosages and regimens may contribute to this ambiguity and makes a comparison of their efficacies in treating disease difficult (37).…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock

Luyer¹,

Buurman²,

Hadfoune³

et al. 2005

Infect Immun

101

View full text Add to dashboard Cite

show abstract

“…The significance and magnitude of the effect of host genetics on gut microfloral composition and functionality is difficult to accurately determine [94,95]. It is generally agreed on that initial colonisation has the greatest effect on the lifelong bacterial types and functionality.…”

Section: The Effect Of Probiotics On Autoimmune-associated Inflammationmentioning

confidence: 99%

Probiotics Applications in Autoimmune Diseases

Al‐Salami¹,

Caccetta²,

Goločorbin-Kon³

et al. 2012

Probiotics

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“…Because of the numerous beneficial properties that have been attributed to LAB, these are the most commonly used probiotic microorganisms that can be defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host" [41]. Probiotic microorganisms, including strains of lactobacilli, bifidobacteria, and Saccharomyces, can potentiate the effect of conventional treatments for experimental colitis or other IBD in humans [22,42,43]. Table 2 describes some examples of human clinical trials where probiotics were shown to be effective in the prevention or treatment of different IBD.…”

Section: Use Of Probiotics In the Treatment Of Colitismentioning

confidence: 99%

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Carmen

LeBlanc

Miyoshi

et al. 2011

Ulcers

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Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.

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Probiotics in inflammatory bowel disease: a critical review

Cited by 65 publications

References 55 publications

Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock

Strain-Specific Effects of Probiotics on Gut Barrier Integrity following Hemorrhagic Shock

Probiotics Applications in Autoimmune Diseases

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

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